| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 3 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 4 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 5 | Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma | Cancer Cell | 2012 | 1,664 |
| 6 | REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants | American Journal of Human Genetics | 2016 | 1,555 |
| 7 | Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy | Cancer Cell | 2014 | 1,358 |
| 8 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,191 |
| 9 | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer | Nature | 2007 | 1,117 |
| 10 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 11 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 12 | A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types | Cell | 2008 | 1,007 |
| 13 | Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays | PLoS Genetics | 2008 | 892 |
| 14 | Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial | Lancet, The | 2016 | 878 |
| 15 | Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer | Nature Reviews Cancer | 2015 | 839 |
| 16 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 17 | Recessive Symptomatic Focal Epilepsy and Mutant Contactin-Associated Protein-like 2 | New England Journal of Medicine | 2006 | 576 |
| 18 | Clonal competition with alternating dominance in multiple myeloma | Blood | 2012 | 575 |
| 19 | Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis | Science Advances | 2020 | 571 |
| 20 | HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials | Lancet, The | 2015 | 562 |
| 21 | Translating RNA sequencing into clinical diagnostics: opportunities and challenges | Nature Reviews Genetics | 2016 | 558 |
| 22 | Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing | Science Translational Medicine | 2012 | 557 |
| 23 | Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 529 |
| 24 | Genome-wide Analyses Identify KIF5A as a Novel ALS Gene | Neuron | 2018 | 517 |
| 25 | Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota | Cell Host and Microbe | 2018 | 517 |
| 26 | Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma | PLoS Medicine | 2008 | 499 |
| 27 | A survey of genetic human cortical gene expression | Nature Genetics | 2007 | 488 |
| 28 | Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers | Kidney International | 2012 | 486 |
| 29 | A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer's Disease | Journal of Clinical Psychiatry | 2007 | 484 |
| 30 | Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma | Cancer Cell | 2016 | 482 |
| 31 | Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions | Nature Genetics | 2010 | 479 |
| 32 | Molecular Mechanisms of Glioma Cell Migration and Invasion | Journal of Neuro-Oncology | 2004 | 476 |
| 33 | Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer | Nature Medicine | 2019 | 476 |
| 34 | Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect | New England Journal of Medicine | 2009 | 469 |
| 35 | GAB2 Alleles Modify Alzheimer's Risk in APOE ɛ4 Carriers | Neuron | 2007 | 451 |
| 36 | Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor | New England Journal of Medicine | 2015 | 438 |
| 37 | A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma | Nature | 2011 | 413 |
| 38 | Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer | Nature Communications | 2015 | 409 |
| 39 | A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer | Nature Genetics | 2014 | 408 |
| 40 | Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations | Cancer Discovery | 2014 | 395 |
| 41 | Common Kibra Alleles Are Associated with Human Memory Performance | Science | 2006 | 391 |
| 42 | An anatomic transcriptional atlas of human glioblastoma | Science | 2018 | 384 |
| 43 | Yersinia pestis and the Plague of Justinian 541–543 AD: a genomic analysis | Lancet Infectious Diseases, The | 2014 | 358 |
| 44 | Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides | Blood | 2012 | 357 |
| 45 | Single-Arm Phases 1 and 2 Trial of Niraparib in Combination With Pembrolizumab in Patients With Recurrent Platinum-Resistant Ovarian Carcinoma | JAMA Oncology | 2019 | 355 |
| 46 | A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease | Pharmacogenomics Journal | 2010 | 351 |
| 47 | Perineural invasion and associated pain in pancreatic cancer | Nature Reviews Cancer | 2011 | 348 |
| 48 | Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders | ACS Nano | 2019 | 341 |
| 49 | Autocrine Factors That Sustain Glioma Invasion and Paracrine Biology in the Brain Microenvironment | Journal of the National Cancer Institute | 2007 | 339 |
| 50 | Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma | Blood | 2018 | 335 |
