| # | Title | Journal | Year | Citations |
|---|
| 1 | Polychemotherapy in advanced non small cell lung cancer: a meta-analysis | Lancet, The | 1993 | 493 |
| 2 | A Multicenter Study Comparing Two Numerical Versions of the Edmonton Symptom Assessment System in Palliative Care Patients | Journal of Pain and Symptom Management | 2011 | 290 |
| 3 | Screening for Distress in Lung and Breast Cancer Outpatients: A Randomized Controlled Trial | Journal of Clinical Oncology | 2010 | 284 |
| 4 | Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026] | Breast Cancer Research | 2006 | 243 |
| 5 | Effect of Standard vs Dose-Escalated Radiation Therapy for Patients With Intermediate-Risk Prostate Cancer | JAMA Oncology | 2018 | 238 |
| 6 | Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial | Annals of Oncology | 2003 | 237 |
| 7 | Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002) | Journal of Clinical Oncology | 2021 | 195 |
| 8 | International Patterns of Practice in Palliative Radiotherapy for Painful Bone Metastases: Evidence-Based Practice? | International Journal of Radiation Oncology Biology Physics | 2009 | 187 |
| 9 | Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial | Lancet Oncology, The | 2014 | 171 |
| 10 | Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial | Lancet Oncology, The | 2012 | 168 |
| 11 | EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4–Positive Solid Tumors, Including Metastatic Urothelial Carcinoma | Journal of Clinical Oncology | 2020 | 159 |
| 12 | International Brachytherapy Practice Patterns: A Survey of the Gynecologic Cancer Intergroup (GCIG) | International Journal of Radiation Oncology Biology Physics | 2012 | 149 |
| 13 | Serial Plasma Osteopontin Levels Have Prognostic Value in Metastatic Breast Cancer | Clinical Cancer Research | 2006 | 147 |
| 14 | Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer | Supportive Care in Cancer | 2016 | 146 |
| 15 | A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies | Blood | 2012 | 145 |
| 16 | Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial | Lancet, The | 2023 | 144 |
| 17 | A randomized phase 3 trial of thalidomide and prednisone as maintenance therapy after ASCT in patients with MM with a quality-of-life assessment: the National Cancer Institute of Canada Clinicals Trials Group Myeloma 10 Trial | Blood | 2013 | 137 |
| 18 | Short Term Androgen Deprivation Therapy Without or With Pelvic Lymph Node Treatment Added to Prostate Bed Only Salvage Radiotherapy: The NRG Oncology/RTOG 0534 SPPORT Trial | International Journal of Radiation Oncology Biology Physics | 2018 | 130 |
| 19 | High Busulfan Exposure Is Associated with Worse Outcomes in a Daily i.v. Busulfan and Fludarabine Allogeneic Transplant Regimen | Biology of Blood and Marrow Transplantation | 2008 | 128 |
| 20 | Survival after recurrent osteosarcoma: Data from 3 European Osteosarcoma Intergroup (EOI) randomized controlled trials | European Journal of Cancer | 2011 | 116 |
| 21 | Aptima HPV E6/E7 mRNA Test Is as Sensitive as Hybrid Capture 2 Assay but More Specific at Detecting Cervical Precancer and Cancer | Journal of Clinical Microbiology | 2011 | 114 |
| 22 | Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells | Journal of Biological Chemistry | 2015 | 114 |
| 23 | Effect of Chemotherapy With Docetaxel With Androgen Suppression and Radiotherapy for Localized High-Risk Prostate Cancer: The Randomized Phase III NRG Oncology RTOG 0521 Trial | Journal of Clinical Oncology | 2019 | 112 |
| 24 | Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia: extended phase 3 results from RESONATE-2 | Haematologica | 2018 | 111 |
| 25 | Current Landscape of Immunotherapy in the Treatment of Solid Tumours, with Future Opportunities and Challenges | Current Oncology | 2018 | 109 |
| 26 | Analysis of Sperm Chromosome Complements Before, During, and After Chemotherapy | Cancer Genetics and Cytogenetics | 1999 | 101 |
| 27 | A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain | Journal of Pain and Symptom Management | 1997 | 97 |
| 28 | Mind-Body Therapies in Cancer: What Is the Latest Evidence? | Current Oncology Reports | 2017 | 92 |
| 29 | Assessment of Treatment With Sorafenib Plus Doxorubicin vs Sorafenib Alone in Patients With Advanced Hepatocellular Carcinoma | JAMA Oncology | 2019 | 91 |
| 30 | Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia | Blood Advances | 2022 | 91 |
| 31 | Phase II study of oral ridaforolimus in women with recurrent or metastatic endometrial cancer | Gynecologic Oncology | 2014 | 84 |
| 32 | Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma | Investigational New Drugs | 2004 | 81 |
| 33 | An Open-Label, Multi-Dose Efficacy and Safety Study of Intramuscular Tetrodotoxin in Patients with Severe Cancer-Related Pain | Journal of Pain and Symptom Management | 2007 | 81 |
| 34 | A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial | Investigational New Drugs | 2006 | 80 |
| 35 | Allogeneic Transplantation for Adult Acute Leukemia in First and Second Remission with a Novel Regimen Incorporating Daily Intravenous Busulfan, Fludarabine, 400 CGY Total-Body Irradiation, and Thymoglobulin | Biology of Blood and Marrow Transplantation | 2007 | 80 |
| 36 | Patterns of failure for glioblastoma multiforme following concurrent radiation and temozolomide | Journal of Medical Imaging and Radiation Oncology | 2011 | 80 |
| 37 | Evaluation of surgical staging in stage I low malignant potential ovarian tumors | Gynecologic Oncology | 1991 | 78 |
| 38 | Patient‐related factors independently impact overall survival in patients with myelodysplastic syndromes: an MDS‐CAN prospective study | British Journal of Haematology | 2016 | 78 |
| 39 | Decreased treatment failure in recipients of HLA-identical bone marrow or peripheral blood stem cell transplants with high CD34 cell doses | British Journal of Haematology | 2003 | 77 |
| 40 | High dose calcitriol may reduce thrombosis in cancer patients | British Journal of Haematology | 2006 | 76 |
| 41 | Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT | Bone Marrow Transplantation | 2018 | 75 |
| 42 | Canadian Association of Pathologists–Association canadienne des pathologistes National Standards Committee/Immunohistochemistry | American Journal of Clinical Pathology | 2010 | 74 |
| 43 | Phase I/II Trial of Custirsen (OGX-011), an Inhibitor of Clusterin, in Combination with a Gemcitabine and Platinum Regimen in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer | Journal of Thoracic Oncology | 2012 | 74 |
| 44 | Phase II study of CGP 69846A (ISIS 5132) in recurrent epithelial ovarian cancer: an NCIC clinical trials group study (NCIC IND.116)☆ | Gynecologic Oncology | 2003 | 73 |
| 45 | Clinical Performance of the PreTect HPV-Proofer E6/E7 mRNA Assay in Comparison with That of the Hybrid Capture 2 Test for Identification of Women at Risk of Cervical Cancer | Journal of Clinical Microbiology | 2010 | 71 |
| 46 | Estimating the Need for Radiotherapy for Patients With Prostate, Breast, and Lung Cancers: Verification of Model Estimates of Need With Radiotherapy Utilization Data From British Columbia | International Journal of Radiation Oncology Biology Physics | 2011 | 71 |
| 47 | Modulation of natural killer cell activity by tamoxifen in stage I post-menopausal breast cancer | European Journal of Cancer & Clinical Oncology | 1987 | 70 |
| 48 | Phase III randomized study of sorafenib plus doxorubicin versus sorafenib in patients with advanced hepatocellular carcinoma (HCC): CALGB 80802 (Alliance). | Journal of Clinical Oncology | 2016 | 69 |
| 49 | Telehealth-delivered group smoking cessation for rural and urban participants: Feasibility and cessation rates | Addictive Behaviors | 2012 | 68 |
| 50 | Ten years results of the Canadian breast intensity modulated radiation therapy (IMRT) randomized controlled trial | Radiotherapy and Oncology | 2016 | 68 |
