| # | Title | Journal | Year | Citations |
|---|
| 1 | Principles of nanoparticle design for overcoming biological barriers to drug delivery | Nature Biotechnology | 2015 | 4,868 |
| 2 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 3 | Doppler Tissue Imaging: A Noninvasive Technique for Evaluation of Left Ventricular Relaxation and Estimation of Filling Pressures | Journal of the American College of Cardiology | 1997 | 2,720 |
| 4 | Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis | New England Journal of Medicine | 2014 | 2,411 |
| 5 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Critical Care Medicine | 2017 | 2,336 |
| 6 | Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation | Journal of the American Society of Echocardiography | 2017 | 2,269 |
| 7 | Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients | New England Journal of Medicine | 2017 | 2,249 |
| 8 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 | Intensive Care Medicine | 2008 | 2,078 |
| 9 | Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis | New England Journal of Medicine | 2011 | 1,588 |
| 10 | Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance | Nature | 2015 | 1,498 |
| 11 | A clinicopathologic analysis of adriamycin cardiotoxicity | Cancer | 1973 | 1,446 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 13 | Ranibizumab for Diabetic Macular Edema | Ophthalmology | 2012 | 1,392 |
| 14 | More than 50 long-term effects of COVID-19: a systematic review and meta-analysis | Scientific Reports | 2021 | 1,358 |
| 15 | A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned | Spine Journal | 2011 | 1,328 |
| 16 | ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death | Journal of the American College of Cardiology | 2006 | 1,280 |
| 17 | Stroke-Associated Pneumonia: Major Advances and Obstacles | Cerebrovascular Diseases | 2013 | 1,166 |
| 18 | A Preoperative Nomogram for Disease Recurrence Following Radical Prostatectomy for Prostate Cancer | Journal of the National Cancer Institute | 1998 | 1,156 |
| 19 | Current and Evolving Echocardiographic Techniques for the Quantitative Evaluation of Cardiac Mechanics: ASE/EAE Consensus Statement on Methodology and Indications | Journal of the American Society of Echocardiography | 2011 | 1,026 |
| 20 | Comparative Dose Efficacy Study of Atorvastatin Versus Simvastatin, Pravastatin, Lovastatin, and Fluvastatin in Patients With Hypercholesterolemia (The CURVES Study) fn1fn1This study was supported by Parke-Davis, Division of Warner Lambert Company, Morris Plains, New Jersey. Manuscript received August 20, 1997; revised manuscript received and accepted November 24, 1997. | American Journal of Cardiology | 1998 | 1,004 |
| 21 | Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma | Blood | 2011 | 984 |
| 22 | Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma | JAMA - Journal of the American Medical Association | 2015 | 982 |
| 23 | Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study | Lancet, The | 2011 | 964 |
| 24 | Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. | Circulation | 1986 | 955 |
| 25 | Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study | Gastroenterology | 2021 | 913 |
| 26 | Ranibizumab for Macular Edema following Central Retinal Vein Occlusion | Ophthalmology | 2010 | 911 |
| 27 | The John Insall Award: Patient Expectations Affect Satisfaction with Total Knee Arthroplasty | Clinical Orthopaedics and Related Research | 2006 | 904 |
| 28 | Transcatheter Aortic Valve Replacement Using a Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis at Extreme Risk for Surgery | Journal of the American College of Cardiology | 2014 | 902 |
| 29 | Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice | European Journal of Echocardiography | 2009 | 890 |
| 30 | Hepatocellular carcinoma: a review | Journal of Hepatocellular Carcinoma | 2016 | 842 |
| 31 | T cell subsets and their signature cytokines in autoimmune and inflammatory diseases | Cytokine | 2015 | 810 |
| 32 | Current and Evolving Echocardiographic Techniques for the Quantitative Evaluation of Cardiac Mechanics: ASE/EAE Consensus Statement on Methodology and Indications Endorsed by the Japanese Society of Echocardiography | European Journal of Echocardiography | 2011 | 796 |
| 33 | Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology | Journal of Thoracic Oncology | 2013 | 792 |
| 34 | Randomized, Double-Masked, Sham-Controlled Trial of Ranibizumab for Neovascular Age-related Macular Degeneration: PIER Study Year 1 | American Journal of Ophthalmology | 2008 | 766 |
| 35 | EAE/ASE Recommendations for Image Acquisition and Display Using Three-Dimensional Echocardiography | Journal of the American Society of Echocardiography | 2012 | 760 |
| 36 | Subcutaneous Low-Molecular-Weight Heparin Compared with Continuous Intravenous Heparin in the Treatment of Proximal-Vein Thrombosis | New England Journal of Medicine | 1992 | 744 |
| 37 | Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon | Science | 1987 | 728 |
| 38 | Long-term Outcomes of Ranibizumab Therapy for Diabetic Macular Edema: The 36-Month Results from Two Phase III Trials | Ophthalmology | 2013 | 728 |
| 39 | Pulsed Doppler echocardiographic determination of stroke volume and cardiac output: clinical validation of two new methods using the apical window. | Circulation | 1984 | 717 |
| 40 | A molecular theory of lipid-protein interactions in the plasma lipoproteins | FEBS Letters | 1974 | 701 |
| 41 | The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics | Nature Reviews Gastroenterology and Hepatology | 2021 | 701 |
| 42 | Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome | Breast Cancer Research | 2004 | 690 |
| 43 | Irritable bowel syndrome | Nature Reviews Disease Primers | 2016 | 674 |
| 44 | Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial | Lancet, The | 2014 | 672 |
| 45 | Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy | 2020 | 669 |
| 46 | XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway | Nature | 2014 | 663 |
| 47 | Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults | Critical Care Medicine | 2019 | 637 |
| 48 | HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma | JAMA Oncology | 2017 | 608 |
| 49 | An inducible caspase 9 safety switch for T-cell therapy | Blood | 2005 | 607 |
| 50 | Optic Disc Edema, Globe Flattening, Choroidal Folds, and Hyperopic Shifts Observed in Astronauts after Long-duration Space Flight | Ophthalmology | 2011 | 596 |
