| # | Title | Journal | Year | Citations |
|---|
| 1 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) | JAMA - Journal of the American Medical Association | 2016 | 16,554 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus | Arthritis and Rheumatism | 2012 | 3,838 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene | Science | 2006 | 2,739 |
| 6 | Assessment of Clinical Criteria for Sepsis | JAMA - Journal of the American Medical Association | 2016 | 2,727 |
| 7 | Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy | Nature Medicine | 2007 | 2,657 |
| 8 | Strong Association of De Novo Copy Number Mutations with Autism | Science | 2007 | 2,497 |
| 9 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 10 | The gut microbiota influences blood-brain barrier permeability in mice | Science Translational Medicine | 2014 | 1,589 |
| 11 | Physiology and immunology of the cholinergic antiinflammatory pathway | Journal of Clinical Investigation | 2007 | 1,274 |
| 12 | HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection | Annual Review of Immunology | 2011 | 1,230 |
| 13 | Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit | Science | 2011 | 1,158 |
| 14 | Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | Nature Genetics | 2010 | 1,132 |
| 15 | 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus | Arthritis and Rheumatology | 2019 | 1,098 |
| 16 | Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large‐scale meta‐analysis of 3,211,768 patients and 113,383,368 controls | World Psychiatry | 2017 | 1,082 |
| 17 | iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL | Blood | 2018 | 1,069 |
| 18 | Reflex control of immunity | Nature Reviews Immunology | 2009 | 969 |
| 19 | Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial | Lancet, The | 2007 | 949 |
| 20 | Thyroid Disease and the Heart | Circulation | 2007 | 941 |
| 21 | Vitamin D and the Immune System | Journal of Investigative Medicine | 2011 | 827 |
| 22 | Sepsis: a roadmap for future research | Lancet Infectious Diseases, The | 2015 | 827 |
| 23 | Endogenous HMGB1 regulates autophagy | Journal of Cell Biology | 2010 | 819 |
| 24 | Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis | Nature Genetics | 2012 | 768 |
| 25 | HMGB1 in health and disease | Molecular Aspects of Medicine | 2014 | 763 |
| 26 | Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry | Nature Immunology | 2019 | 760 |
| 27 | 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 759 |
| 28 | Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 742 |
| 29 | HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2 | Shock | 2006 | 730 |
| 30 | A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus | Nature Genetics | 2009 | 729 |
| 31 | A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 705 |
| 32 | Novel role of PKR in inflammasome activation and HMGB1 release | Nature | 2012 | 672 |
| 33 | Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 659 |
| 34 | Genome-wide association study in alopecia areata implicates both innate and adaptive immunity | Nature | 2010 | 651 |
| 35 | Macrophage Migration Inhibitory Factor Provides Cardioprotection During Ischemia/Reperfusion by Reducing Oxidative Stress | Antioxidants and Redox Signaling | 2011 | 636 |
| 36 | The vagus nerve and the inflammatory reflex—linking immunity and metabolism | Nature Reviews Endocrinology | 2012 | 635 |
| 37 | Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis | Journal of Experimental Medicine | 2006 | 630 |
| 38 | A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus | Nature Genetics | 2006 | 593 |
| 39 | Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release | Journal of Experimental Medicine | 2012 | 590 |
| 40 | Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution | Nature Genetics | 2013 | 588 |
| 41 | AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial | Lancet Neurology, The | 2011 | 582 |
| 42 | The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo | Blood | 2012 | 564 |
| 43 | AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism | Journal of Biological Chemistry | 2010 | 560 |
| 44 | High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis | Nature Genetics | 2012 | 558 |
| 45 | Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70− | Journal of Experimental Medicine | 2011 | 552 |
| 46 | Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials | Lancet, The | 2018 | 547 |
| 47 | Reversing Established Sepsis in Rats with Human Vasoactive Hormone Adrenomedullin and its Binding Protein | Molecular Medicine | 2009 | 546 |
| 48 | Pervasive Sharing of Genetic Effects in Autoimmune Disease | PLoS Genetics | 2011 | 540 |
| 49 | Sepsis: Current Dogma and New Perspectives | Immunity | 2014 | 533 |
| 50 | A jump-start for electroceuticals | Nature | 2013 | 523 |
