| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 3 | Tumor Angiogenesis | New England Journal of Medicine | 2008 | 1,996 |
| 4 | Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma | JAMA - Journal of the American Medical Association | 2015 | 1,874 |
| 5 | Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 | Nucleic Acids Research | 2016 | 1,323 |
| 6 | Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis | Clinical Microbiology and Infection | 2020 | 1,043 |
| 7 | BCL-2 family proteins: changing partners in the dance towards death | Cell Death and Differentiation | 2018 | 1,037 |
| 8 | The Genome of the Sea Urchin Strongylocentrotus purpuratus | Science | 2006 | 1,018 |
| 9 | A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers | Journal of Clinical Epidemiology | 2009 | 1,013 |
| 10 | Colorectal cancer screening: a global overview of existing programmes | Gut | 2015 | 899 |
| 11 | Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia | Nature Medicine | 2007 | 804 |
| 12 | Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound | Nature Communications | 2018 | 618 |
| 13 | The ctenophore genome and the evolutionary origins of neural systems | Nature | 2014 | 606 |
| 14 | Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype | Nature Medicine | 2010 | 588 |
| 15 | Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution | Nature Genetics | 2013 | 588 |
| 16 | Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity | Cell Death and Differentiation | 2017 | 521 |
| 17 | The immune gene repertoire encoded in the purple sea urchin genome | Developmental Biology | 2006 | 513 |
| 18 | Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis | Clinical Microbiology and Infection | 2021 | 512 |
| 19 | Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses | European Heart Journal | 2017 | 510 |
| 20 | Overview of Therapeutic Ultrasound Applications and Safety Considerations | Journal of Ultrasound in Medicine | 2012 | 493 |
| 21 | The Burden of Opioid-Related Mortality in the United States | JAMA Network Open | 2018 | 484 |
| 22 | Molecular landmarks of tumor hypoxia across cancer types | Nature Genetics | 2019 | 480 |
| 23 | MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study | Lancet Neurology, The | 2013 | 475 |
| 24 | Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial | Lancet, The | 2017 | 469 |
| 25 | Identifying and Characterizing circRNA-Protein Interaction | Theranostics | 2017 | 467 |
| 26 | Vascular dysfunction—The disregarded partner of Alzheimer's disease | Alzheimer's and Dementia | 2019 | 454 |
| 27 | Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa | Nature Reviews Clinical Oncology | 2018 | 412 |
| 28 | Perivascular spaces in the brain: anatomy, physiology and pathology | Nature Reviews Neurology | 2020 | 405 |
| 29 | Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study | Scientific Reports | 2019 | 400 |
| 30 | Genomic Insights into the Immune System of the Sea Urchin | Science | 2006 | 384 |
| 31 | Increasing Hospital Admission Rates for Urological Complications After Transrectal Ultrasound Guided Prostate Biopsy | Journal of Urology | 2010 | 378 |
| 32 | Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes | New England Journal of Medicine | 2020 | 335 |
| 33 | Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease | PLoS ONE | 2010 | 319 |
| 34 | Widespread and Functional RNA Circularization in Localized Prostate Cancer | Cell | 2019 | 317 |
| 35 | Increasing Hospital Admission Rates for Urological Complications After Transrectal Ultrasound Guided Prostate Biopsy | Journal of Urology | 2013 | 312 |
| 36 | First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound | Nature Communications | 2019 | 312 |
| 37 | Circbank: a comprehensive database for circRNA with standard nomenclature | RNA Biology | 2019 | 309 |
| 38 | Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions–based Controller | Radiology | 2012 | 308 |
| 39 | Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis | Oncogene | 2016 | 306 |
| 40 | The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations | Journal of Alzheimer's Disease | 2017 | 306 |
| 41 | A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair | Theranostics | 2017 | 297 |
| 42 | MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8 | Oncogene | 2011 | 296 |
| 43 | Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future | Alzheimer's and Dementia | 2013 | 292 |
| 44 | Vessel co-option in cancer | Nature Reviews Clinical Oncology | 2019 | 285 |
| 45 | Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound | Experimental Neurology | 2013 | 265 |
| 46 | Cytokine Modulation of TLR Expression and Activation in Mesenchymal Stromal Cells Leads to a Proinflammatory Phenotype | Journal of Immunology | 2009 | 262 |
| 47 | A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation | Cell Death and Differentiation | 2017 | 252 |
| 48 | White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities | Alzheimer's and Dementia: Translational Research and Clinical Interventions | 2019 | 250 |
| 49 | Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier | PLoS ONE | 2011 | 234 |
| 50 | Maternal Anxiety During Pregnancy and the Association With Adverse Perinatal Outcomes | Journal of Clinical Psychiatry | 2018 | 230 |
