| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 3 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 4 | A Meta-Analysis of Cytokines in Major Depression | Biological Psychiatry | 2010 | 3,771 |
| 5 | Assessment of Clinical Criteria for Sepsis | JAMA - Journal of the American Medical Association | 2016 | 2,727 |
| 6 | PI-RADS Prostate Imaging – Reporting and Data System: 2015, Version 2 | European Urology | 2016 | 2,290 |
| 7 | American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography | Ca-A Cancer Journal for Clinicians | 2007 | 2,234 |
| 8 | Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults | Annals of Internal Medicine | 2015 | 2,001 |
| 9 | Tumor Angiogenesis | New England Journal of Medicine | 2008 | 1,996 |
| 10 | Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma | JAMA - Journal of the American Medical Association | 2015 | 1,874 |
| 11 | Prevention of VTE in Nonorthopedic Surgical Patients | Chest | 2012 | 1,819 |
| 12 | Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis | Cancer Cell | 2009 | 1,624 |
| 13 | Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) | Intensive Care Medicine | 2020 | 1,536 |
| 14 | Improving the reporting of pragmatic trials: an extension of the CONSORT statement | BMJ: British Medical Journal | 2008 | 1,327 |
| 15 | Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 | Nucleic Acids Research | 2016 | 1,323 |
| 16 | Gastrointestinal Quality of Life Index: Development, validation and application of a new instrument | British Journal of Surgery | 2005 | 1,042 |
| 17 | A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers | Journal of Clinical Epidemiology | 2009 | 1,013 |
| 18 | Clinical Results of Long-Term Follow-Up of a Large, Active Surveillance Cohort With Localized Prostate Cancer | Journal of Clinical Oncology | 2010 | 1,011 |
| 19 | Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro | Immunity | 2002 | 1,003 |
| 20 | Mortality among Patients Admitted to Hospitals on Weekends as Compared with Weekdays | New England Journal of Medicine | 2001 | 990 |
| 21 | Long-Term Follow-Up of a Large Active Surveillance Cohort of Patients With Prostate Cancer | Journal of Clinical Oncology | 2015 | 985 |
| 22 | Critical care and the global burden of critical illness in adults | Lancet, The | 2010 | 976 |
| 23 | Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study | Lancet, The | 2016 | 962 |
| 24 | MULTI-INFARCT DEMENTIA A CAUSE OF MENTAL DETERIORATION IN THE ELDERLY | Lancet, The | 1974 | 935 |
| 25 | Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan | Experimental Cell Research | 1993 | 922 |
| 26 | Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome | American Journal of Respiratory and Critical Care Medicine | 2018 | 911 |
| 27 | Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits | BMJ: British Medical Journal | 2005 | 908 |
| 28 | Colorectal cancer screening: a global overview of existing programmes | Gut | 2015 | 899 |
| 29 | A Meta-Analysis of Cytokines in Alzheimer's Disease | Biological Psychiatry | 2010 | 851 |
| 30 | Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection | New England Journal of Medicine | 2018 | 821 |
| 31 | Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) | Critical Care Medicine | 2020 | 816 |
| 32 | Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study | Lancet Oncology, The | 2019 | 812 |
| 33 | Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2014 | 800 |
| 34 | THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE | Lancet, The | 1989 | 779 |
| 35 | Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial | Lancet Oncology, The | 2017 | 776 |
| 36 | A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor | New England Journal of Medicine | 2016 | 770 |
| 37 | Critically Ill Patients With 2009 Influenza A(H1N1) in Mexico | JAMA - Journal of the American Medical Association | 2009 | 755 |
| 38 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013 | Bipolar Disorders | 2013 | 740 |
| 39 | Inspiratory Muscle Unloading by Neurally Adjusted Ventilatory Assist During Maximal Inspiratory Efforts in Healthy Subjects | Chest | 2007 | 729 |
| 40 | Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2020 | 710 |
| 41 | Stereotactic Ablative Radiotherapy for the Comprehensive Treatment of Oligometastatic Cancers: Long-Term Results of the SABR-COMET Phase II Randomized Trial | Journal of Clinical Oncology | 2020 | 683 |
| 42 | Advances in ultrasound biomicroscopy | Ultrasound in Medicine and Biology | 2000 | 664 |
| 43 | A Multicenter Randomized Trial of Breast Intensity-Modulated Radiation Therapy to Reduce Acute Radiation Dermatitis | Journal of Clinical Oncology | 2008 | 663 |
| 44 | Lay health workers in primary and community health care for maternal and child health and the management of infectious diseases | The Cochrane Library | 2010 | 641 |
| 45 | Quantitative interpretation of magnetization transfer | Magnetic Resonance in Medicine | 1993 | 640 |
| 46 | Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors | American Journal of Pathology | 1997 | 634 |
| 47 | Grey zones of clinical practice: some limits to evidence-based medicine | Lancet, The | 1995 | 628 |
| 48 | Exploring the rising incidence of neuroendocrine tumors: A population‐based analysis of epidemiology, metastatic presentation, and outcomes | Cancer | 2015 | 627 |
| 49 | The Impact of Maternal Depression During Pregnancy on Perinatal Outcomes | Journal of Clinical Psychiatry | 2013 | 627 |
| 50 | Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound | Nature Communications | 2018 | 618 |
