| Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study | Lancet, The | 2016 | 935 |
| Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2016 | 621 |
| Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study | Lancet Oncology, The | 2016 | 536 |
| EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Disease-specific and Overall Survival in Non-Muscle-invasive Stage Ta-T1 Urothelial Bladder Cancer Patients Treated with 1-3 Years of Maintenance Bacillus Calmette-Guérin | European Urology | 2016 | 284 |
| ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis | Clinical Nutrition | 2016 | 231 |
| Pathophysiology of irritable bowel syndrome | The Lancet Gastroenterology and Hepatology | 2016 | 224 |
| The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis | Hepatology | 2016 | 184 |
| ESTRO-ACROP guideline "target delineation of glioblastomas" | Radiotherapy and Oncology | 2016 | 180 |
| BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults | Thorax | 2016 | 178 |
| Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: A cohort study | Journal of Allergy and Clinical Immunology | 2016 | 163 |
| Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses | Molecular Therapy | 2016 | 133 |
| Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer | Supportive Care in Cancer | 2016 | 114 |
| Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial | Lancet, The | 2016 | 113 |
| Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes | Progress in Retinal and Eye Research | 2016 | 109 |
| Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer | British Journal of Cancer | 2016 | 102 |
| Systematic review with meta-analysis: the adverse effects of tobacco smoking on the natural history of Crohn's disease | Alimentary Pharmacology and Therapeutics | 2016 | 102 |
| Microbial Etiology of Pneumonia: Epidemiology, Diagnosis and Resistance Patterns | International Journal of Molecular Sciences | 2016 | 100 |
| Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) | World Journal of Emergency Surgery | 2016 | 95 |
| Time-dependent changes in mortality and transformation risk in MDS | Blood | 2016 | 93 |
| A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma | Clinical Cancer Research | 2016 | 89 |
| 30-day mortality after systemic anticancer treatment for breast and lung cancer in England: a population-based, observational study | Lancet Oncology, The | 2016 | 88 |
| Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer | Nature Communications | 2016 | 86 |
| Minimal residual disease is an independent predictor for 10-year survival in CLL | Blood | 2016 | 85 |
| Poor Correlation Between Clinical Disease Activity and Mucosal Inflammation, and the Role of Psychological Comorbidity, in Inflammatory Bowel Disease | American Journal of Gastroenterology | 2016 | 84 |
| British Society of Breast Radiology Annual Scientific Meeting 2016 | Breast Cancer Research | 2016 | 78 |
