| # | Title | Journal | Year | Citations |
|---|
| 1 | Classification and natural history of clinically identifiable subtypes of cerebral infarction | Lancet, The | 1991 | 2,953 |
| 2 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial | Lancet, The | 2005 | 2,854 |
| 3 | Revised International Prognostic Scoring System for Myelodysplastic Syndromes | Blood | 2012 | 2,458 |
| 4 | A Phase 3 Trial of Bevacizumab in Ovarian Cancer | New England Journal of Medicine | 2011 | 1,843 |
| 5 | International consensus report on the investigation and management of primary immune thrombocytopenia | Blood | 2010 | 1,802 |
| 6 | MicroRNAs in cancer: biomarkers, functions and therapy | Trends in Molecular Medicine | 2014 | 1,732 |
| 7 | Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis | Clinical Gastroenterology and Hepatology | 2012 | 1,624 |
| 8 | Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial | Lancet, The | 2017 | 1,475 |
| 9 | Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study | Lancet, The | 2016 | 1,397 |
| 10 | Randomized Trial of Laparoscopic-Assisted Resection of Colorectal Carcinoma: 3-Year Results of the UK MRC CLASICC Trial Group | Journal of Clinical Oncology | 2007 | 1,382 |
| 11 | Connexin 26 mutations in hereditary non-syndromic sensorineural deafness | Nature | 1997 | 1,363 |
| 12 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial | Lancet, The | 2009 | 1,292 |
| 13 | A Scale for the Assessment of Hedonic Tone the Snaith–Hamilton Pleasure Scale | British Journal of Psychiatry | 1995 | 1,180 |
| 14 | Measuring Quality of Life in Routine Oncology Practice Improves Communication and Patient Well-Being: A Randomized Controlled Trial | Journal of Clinical Oncology | 2004 | 1,160 |
| 15 | Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial | Lancet, The | 2000 | 1,096 |
| 16 | SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts | New England Journal of Medicine | 2011 | 1,094 |
| 17 | Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial | Lancet, The | 2015 | 1,042 |
| 18 | Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure | European Respiratory Journal | 2017 | 1,014 |
| 19 | ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications | Journal of Crohn's and Colitis | 2019 | 958 |
| 20 | Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity | Nature Reviews Cancer | 2015 | 928 |
| 21 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial | Lancet, The | 2009 | 906 |
| 22 | Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer | British Journal of Surgery | 2010 | 906 |
| 23 | EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood | Nature Reviews Clinical Oncology | 2021 | 826 |
| 24 | Acute liver failure: redefining the syndromes | Lancet, The | 1993 | 820 |
| 25 | Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma | Leukemia | 2008 | 787 |
| 26 | Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2016 | 785 |
| 27 | Current concepts of molecular aspects of bone healing | Injury | 2005 | 769 |
| 28 | Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis | Gut | 1998 | 762 |
| 29 | Intragenic ERBB2 kinase mutations in tumours | Nature | 2004 | 757 |
| 30 | Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial | Lancet, The | 2019 | 697 |
| 31 | Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis | BMJ: British Medical Journal | 2003 | 678 |
| 32 | Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study | Lancet Oncology, The | 2016 | 676 |
| 33 | Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology | Lancet, The | 1991 | 664 |
| 34 | Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 | Modern Pathology | 2017 | 652 |
| 35 | British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE | Thorax | 2015 | 631 |
| 36 | Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2015 | 621 |
| 37 | The spring in the arch of the human foot | Nature | 1987 | 613 |
| 38 | Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study | Lancet Oncology, The | 2011 | 612 |
| 39 | Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction | Lancet, The | 1991 | 605 |
| 40 | Prelingual Deafness: High Prevalence of a 30delG Mutation in the Connexin 26 Gene | Human Molecular Genetics | 1997 | 601 |
| 41 | Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis | American Journal of Gastroenterology | 2014 | 595 |
| 42 | Long-term follow-up of the Medical Research Council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer | British Journal of Surgery | 2012 | 586 |
| 43 | Impaired auditory recognition of fear and anger following bilateral amygdala lesions | Nature | 1997 | 584 |
| 44 | Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation | Human Molecular Genetics | 1998 | 578 |
| 45 | Pre-eclampsia | Lancet, The | 2000 | 575 |
| 46 | Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies | Clinical Cancer Research | 2014 | 561 |
| 47 | Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology | British Journal of Cancer | 1998 | 549 |
| 48 | Raising awareness of acute kidney injury: a global perspective of a silent killer | Kidney International | 2013 | 541 |
| 49 | ASPM is a major determinant of cerebral cortical size | Nature Genetics | 2002 | 538 |
| 50 | Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial | Lancet Oncology, The | 2014 | 516 |
