| # | Title | Journal | Year | Citations |
|---|
| 1 | A Comparison of Multimodal Therapy and Surgery for Esophageal Adenocarcinoma | New England Journal of Medicine | 1996 | 1,919 |
| 2 | Risks of cancer in BRCA1-mutation carriers | Lancet, The | 1994 | 1,764 |
| 3 | Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults | British Journal of Anaesthesia | 2015 | 1,544 |
| 4 | Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder | Nature Genetics | 2008 | 1,102 |
| 5 | Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study) | Lancet, The | 2004 | 914 |
| 6 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 848 |
| 7 | New method for detecting slime production by coagulase negative staphylococci. | Journal of Clinical Pathology | 1989 | 839 |
| 8 | The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori | Lancet, The | 1993 | 788 |
| 9 | Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody–associated vasculitis | Arthritis and Rheumatism | 2005 | 723 |
| 10 | Targeting Toll-like receptors: emerging therapeutics? | Nature Reviews Drug Discovery | 2010 | 721 |
| 11 | Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study | Lancet, The | 2004 | 665 |
| 12 | Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection | PLoS ONE | 2020 | 634 |
| 13 | Development of the EURO–D scale – a European Union initiative to compare symptoms of depression in 14 European centres | British Journal of Psychiatry | 1999 | 612 |
| 14 | The Natural History of the Frozen Shoulder Syndrome | Scandinavian Journal of Rheumatology | 1975 | 575 |
| 15 | Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients | Journal of Cystic Fibrosis | 2003 | 573 |
| 16 | The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression | Intensive Care Medicine | 2008 | 562 |
| 17 | Loneliness and the health of older people | International Journal of Geriatric Psychiatry | 2008 | 548 |
| 18 | Radiofrequency Ablation vs Endoscopic Surveillance for Patients With Barrett Esophagus and Low-Grade Dysplasia | JAMA - Journal of the American Medical Association | 2014 | 545 |
| 19 | EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases | Annals of the Rheumatic Diseases | 2011 | 533 |
| 20 | EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study | Lancet Oncology, The | 2012 | 526 |
| 21 | Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children | Clinical Infectious Diseases | 2017 | 501 |
| 22 | Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children | Clinical Infectious Diseases | 2017 | 492 |
| 23 | The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes | Molecular Psychiatry | 2006 | 480 |
| 24 | A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum | Scientific Reports | 2020 | 477 |
| 25 | Tumor Type Is a Determinant of Susceptibility to Apoptosis | American Journal of Clinical Pathology | 1995 | 437 |
| 26 | Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder | Journal of the American Academy of Child and Adolescent Psychiatry | 2010 | 423 |
| 27 | Enhancing studies of the connectome in autism using the autism brain imaging data exchange II | Scientific Data | 2017 | 422 |
| 28 | Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017 | JAMA - Journal of the American Medical Association | 2020 | 419 |
| 29 | Nurse-patient communication: an exploration of patients' experiences | Journal of Clinical Nursing | 2004 | 382 |
| 30 | Magnetic Nanoparticles in Cancer Theranostics | Theranostics | 2015 | 373 |
| 31 | The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity | Lancet Respiratory Medicine,the | 2021 | 371 |
| 32 | Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors | Clinical Pharmacokinetics | 2002 | 369 |
| 33 | A Frailty Instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE) | BMC Geriatrics | 2010 | 368 |
| 34 | The Alarmin Interleukin-33 Drives Protective Antiviral CD8 + T Cell Responses | Science | 2012 | 368 |
| 35 | Effect of Smoking on Arterial Stiffness and Pulse Pressure Amplification | Hypertension | 2003 | 357 |
| 36 | Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis | Arthritis and Rheumatism | 2002 | 350 |
| 37 | The roles of microRNA in cancer and apoptosis | Biological Reviews | 2009 | 346 |
| 38 | Role of cardiopulmonary exercise testing as a risk-assessment method in patients undergoing intra-abdominal surgery: a systematic review | British Journal of Anaesthesia | 2016 | 343 |
| 39 | A molecular Swiss army knife: OmpA structure, function and expression | FEMS Microbiology Letters | 2007 | 341 |
| 40 | Detection of Staphylococcal Cassette Chromosome mec Type XI Carrying Highly Divergent mecA , mecI , mecR1 , blaZ , and ccr Genes in Human Clinical Isolates of Clonal Complex 130 Methicillin-Resistant Staphylococcus aureus | Antimicrobial Agents and Chemotherapy | 2011 | 336 |
| 41 | Genome‐wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | 2008 | 335 |
| 42 | Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder | Nature Genetics | 2012 | 334 |
| 43 | Evaluation of a New Computer Intervention to Teach People with Autism or Asperger Syndrome to Recognize and Predict Emotions in Others | Autism | 2001 | 330 |
| 44 | Surgical management and outcomes of colorectal cancer liver metastases | British Journal of Surgery | 2010 | 320 |
| 45 | Long‐term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria | British Journal of Haematology | 2013 | 320 |
| 46 | Characteristics and treatment of patients with G3 gastroenteropancreatic neuroendocrine neoplasms | Endocrine-Related Cancer | 2015 | 316 |
| 47 | The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis | Surgery | 2016 | 316 |
| 48 | Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome | Nature Genetics | 2004 | 313 |
| 49 | Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci | PLoS Genetics | 2011 | 307 |
| 50 | COVID19 coagulopathy in Caucasian patients | British Journal of Haematology | 2020 | 307 |
