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#	Title	Journal	Year	Citations
1	Root microbiota drive direct integration of phosphate stress and immunity	Nature	2017	669
2	Correlated mutations contain information about protein-protein interaction 1 1Edited by A. R. Fersht	Journal of Molecular Biology	1997	498
3	A gene network for navigating the literature	Nature Genetics	2004	432
4	Similarity of phylogenetic trees as indicator of protein–protein interaction	Protein Engineering, Design and Selection	2001	425
5	Computational methods for the prediction of protein interactions	Current Opinion in Structural Biology	2002	330
6	The role of epigenetics in aging and age-related diseases	Ageing Research Reviews	2009	319
7	Prediction of Human Protein Function from Post-translational Modifications and Localization Features	Journal of Molecular Biology	2002	312
8	Practical limits of function prediction	Proteins: Structure, Function and Bioinformatics	2000	306
9	Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior	Cell	2016	280
10	Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis	Advances in Experimental Medicine and Biology	2013	274
11	Intrinsic errors in genome annotation	Trends in Genetics	2001	265
12	In silico two-hybrid system for the selection of physically interacting protein pairs	Proteins: Structure, Function and Bioinformatics	2002	241
13	Prediction of protein-protein interaction sites in heterocomplexes with neural networks	FEBS Journal	2002	225
14	Improving contact predictions by the combination of correlated mutations and other sources of sequence information	Folding & Design	1997	184
15	Automatic extraction of keywords from scientific text: application to the knowledge domain of protein families	Bioinformatics	1998	183
16	Text-mining and information-retrieval services for molecular biology	Genome Biology	2005	180
17	Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes	PLoS ONE	2012	171
18	Transcription regulation and environmental adaptation in bacteria	Trends in Microbiology	2003	168
19	Conserved Clusters of Functionally Related Genes in Two Bacterial Genomes	Journal of Molecular Evolution	1997	163
20	DNA methylation epigenotypes in breast cancer molecular subtypes	Breast Cancer Research	2010	159
21	Effective use of sequence correlation and conservation in fold recognition 1 1Edited by J. M. Thornton	Journal of Molecular Biology	1999	157
22	Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies	PLoS Pathogens	2012	155
23	Cytokinin induces genome-wide binding of the type-B response regulator ARR10 to regulate growth and development in Arabidopsis	Proceedings of the National Academy of Sciences of the United States of America	2017	154
24	Controlled synthesis of uniform magnetite nanocrystals with high-quality properties for biomedical applications	Journal of Materials Chemistry	2012	141
25	Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment	Cellular and Molecular Life Sciences	2019	139
26	CAFASP2: The second critical assessment of fully automated structure prediction methods	Proteins: Structure, Function and Bioinformatics	2001	130
27	Practical limits of function prediction	Proteins: Structure, Function and Bioinformatics	2000	129
28	Virus factories: biogenesis and structural design	Cellular Microbiology	2013	128
29	High‐quality genome‐scale metabolic modelling of Pseudomonas putida highlights its broad metabolic capabilities	Environmental Microbiology	2020	127
30	Cancer induction by restriction of oncogene expression to the stem cell compartment	EMBO Journal	2009	125
31	Label-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces	Nature Materials	2012	120
32	Development of a rapid lateral flow immunoassay test for detection of exosomes previously enriched from cell culture medium and body fluids	Journal of Extracellular Vesicles	2016	114
33	Evaluation of BioCreAtIvE assessment of task 2	BMC Bioinformatics	2005	108
34	Automatic annotation of protein function	Current Opinion in Structural Biology	2005	107
35	Assessment of predictions submitted for the CASP6 comparative modeling category	Proteins: Structure, Function and Bioinformatics	2005	101
36	Genetic and epigenetic regulation of aging	Current Opinion in Immunology	2009	101
37	High sensitivity detection of extracellular vesicles immune-captured from urine by conventional flow cytometry	Scientific Reports	2019	101
38	Metabolic and regulatory rearrangements underlying glycerol metabolism in Pseudomonas putida KT2440	Environmental Microbiology	2014	91
39	Challenging times for bioinformatics	Nature	1995	86
40	Progress in predicting inter-residue contacts of proteins with neural networks and correlated mutations	Proteins: Structure, Function and Bioinformatics	2001	86
41	Information extraction in molecular biology	Briefings in Bioinformatics	2002	85
42	Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide	Hepatology	2010	81
43	Three-dimensional view of the surface motif associated with the P-loop structure: cis and trans cases of convergent evolution 1 1Edited by J. Thornton	Journal of Molecular Biology	2000	78
44	Genetic relationships among biotypes of Bemisia tabaci (Hemiptera: Aleyrodidae) based on AFLP analysis	Bulletin of Entomological Research	2000	75
45	Automatic extraction of biological information from scientific text: protein-protein interactions	Proceedings	1999	75
46	Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma	Nature Communications	2014	73
47	Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles	Nature Communications	2017	71
48	A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008	Biochemical Journal	2013	70
49	RNAiFOLD: A CONSTRAINT PROGRAMMING ALGORITHM FOR RNA INVERSE FOLDING AND MOLECULAR DESIGN	Journal of Bioinformatics and Computational Biology	2013	70
50	Virus assembly factories in a lipid world	Current Opinion in Virology	2016	70

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