| # | Title | Journal | Year | Citations |
|---|
| 1 | Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination | Science | 2000 | 876 |
| 2 | Mechanical, Thermal, and Oxidation Properties of Refractory Hafnium and zirconium Compounds | Journal of the European Ceramic Society | 1999 | 725 |
| 3 | Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches | Journal of Controlled Release | 1990 | 631 |
| 4 | Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes | Nature | 2002 | 628 |
| 5 | Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer | Chemical Reviews | 2009 | 484 |
| 6 | Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 422 |
| 7 | Biodegradable microspheres as a vaccine delivery system | Molecular Immunology | 1991 | 399 |
| 8 | Synthesis and Antimycobacterial Activity of Pyrazine and Quinoxaline Derivatives | Journal of Medicinal Chemistry | 2002 | 397 |
| 9 | Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp. | Journal of Biological Chemistry | 2005 | 381 |
| 10 | Metabolism and mechanism of action of 5-fluorouracil | Journal of Biological Chemistry | 1990 | 373 |
| 11 | Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19 | Journal of Medicinal Chemistry | 2020 | 371 |
| 12 | Smallpox vaccine–induced antibodies are necessary and sufficient for protection against monkeypox virus | Nature Medicine | 2005 | 346 |
| 13 | Concepts for systemic treatment of micrometastases | Cancer | 1975 | 327 |
| 14 | Multi-targeted therapy of cancer by niclosamide: A new application for an old drug | Cancer Letters | 2014 | 303 |
| 15 | Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors | Biochemical Pharmacology | 1999 | 301 |
| 16 | Protection against vaginal SIV transmission with microencapsulated vaccine | Science | 1993 | 295 |
| 17 | Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models | Antimicrobial Agents and Chemotherapy | 2005 | 292 |
| 18 | The Amphipathic α Helix: A Multifunctional Structural Motif in Plasma Apolipoproteins | Advances in Protein Chemistry | 1994 | 276 |
| 19 | A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans | Toxicology | 2009 | 259 |
| 20 | Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin | Vaccine | 2007 | 253 |
| 21 | Controlled Release of a Luteinizing Hormone-Releasing Hormone Analogue from Poly(d,l-lactide—co-glycolide) Microspheres | Journal of Pharmaceutical Sciences | 1984 | 252 |
| 22 | High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv | Tuberculosis | 2009 | 251 |
| 23 | Ancient co-speciation of simian foamy viruses and primates | Nature | 2005 | 248 |
| 24 | The wnt/β‐catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer | Journal of Cellular Biochemistry | 2012 | 239 |
| 25 | Antiviral (RNA) Activity of Selected Amaryllidaceae Isoquinoline Constituents and Synthesis of Related Substances | Journal of Natural Products | 1992 | 234 |
| 26 | Designing for ultrahigh-temperature applications: The mechanical and thermal properties of HfB2, HfCx, HfNxand Hf(N) | Journal of Materials Science | 2004 | 233 |
| 27 | Human immunodeficiency virus type 1, human protein interaction database at NCBI | Nucleic Acids Research | 2009 | 230 |
| 28 | Kinetics of mammary tumor cell growth and implications for therapy | Cancer | 1971 | 227 |
| 29 | ALVAC-SIV- gag - pol - env -Based Vaccination and Macaque Major Histocompatibility Complex Class I (A*01) Delay Simian Immunodeficiency Virus SIV mac -Induced Immunodeficiency | Journal of Virology | 2002 | 225 |
| 30 | Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro | Biochemical and Biophysical Research Communications | 1988 | 223 |
| 31 | Discovery and development of clofarabine: a nucleoside analogue for treating cancer | Nature Reviews Drug Discovery | 2006 | 220 |
| 32 | Energy by reverse electrodialysis | Ocean Engineering | 1980 | 211 |
| 33 | Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug | British Journal of Pharmacology | 2005 | 210 |
| 34 | Release of human serum albumin from poly(lactide-co-glycolide) microspheres | Pharmaceutical Research | 1990 | 205 |
| 35 | Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1 | Antimicrobial Agents and Chemotherapy | 2003 | 203 |
| 36 | NMR study of in vivo RIF-1 tumors | Biochimica Et Biophysica Acta - Molecular Cell Research | 1984 | 202 |
| 37 | Metabolism and antiviral activity of ribavirin | Virus Research | 2005 | 197 |
| 38 | Inactivation of Escherichia coli, Bacteriophage MS2, and Bacillus Spores under UV/H2O2 and UV/Peroxydisulfate Advanced Disinfection Conditions | Environmental Science & Technology | 2016 | 194 |
| 39 | Monolithic Tetracycline‐containing Fibers for Controlled Delivery to Periodontal Pockets | Journal of Periodontology | 1983 | 190 |
| 40 | Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione | Biochemical Pharmacology | 1987 | 190 |
| 41 | Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway | PLoS ONE | 2011 | 187 |
| 42 | Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease | Matrix Biology | 2018 | 184 |
| 43 | Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets | Journal of Virology | 2008 | 181 |
| 44 | Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity | Vaccine | 2000 | 179 |
| 45 | Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides | Journal of Medicinal Chemistry | 1991 | 174 |
| 46 | Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas | Cancer | 1977 | 171 |
| 47 | Failure of cAMP agonists to activate rescued ΔF508 CFTR in CFBE41o-airway epithelial monolayers | Journal of Physiology | 2005 | 169 |
| 48 | Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin | Antimicrobial Agents and Chemotherapy | 2003 | 168 |
| 49 | Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function | American Journal of Respiratory and Critical Care Medicine | 2013 | 168 |
| 50 | Control of SIV Rebound Through Structured Treatment Interruptions During Early Infection | American Journal of Respiratory and Critical Care Medicine | 2000 | 166 |
