| # | Title | Journal | Year | Citations |
|---|
| 1 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial | Lancet Oncology, The | 2009 | 5,104 |
| 2 | Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells | Cellular Physiology and Biochemistry | 2014 | 2,415 |
| 3 | UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentation | | 2020 | 929 |
| 4 | Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis | Journal of Thoracic and Cardiovascular Surgery | 2008 | 537 |
| 5 | 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies | Molecules | 2008 | 515 |
| 6 | The role and mechanisms of action of microRNAs in cancer drug resistance | Clinical Epigenetics | 2019 | 468 |
| 7 | Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease | Oncotarget | 2015 | 449 |
| 8 | Reduced default mode network functional connectivity in patients with recurrent major depressive disorder | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 441 |
| 9 | N6-methyladenosine links RNA metabolism to cancer progression | Cell Death and Disease | 2018 | 381 |
| 10 | The role of STAT3 in autophagy | Autophagy | 2015 | 354 |
| 11 | Microglia mediate forgetting via complement-dependent synaptic elimination | Science | 2020 | 351 |
| 12 | Obesity: Epidemiology, Pathophysiology, and Therapeutics | Frontiers in Endocrinology | 2021 | 339 |
| 13 | European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine) | Clinical Microbiology and Infection | 2022 | 324 |
| 14 | Rectal Cancer: Assessment of Neoadjuvant Chemoradiation Outcome based on Radiomics of Multiparametric MRI | Clinical Cancer Research | 2016 | 322 |
| 15 | ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China | Journal of Antimicrobial Chemotherapy | 2011 | 317 |
| 16 | Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression | International Journal of Infectious Diseases | 2020 | 287 |
| 17 | Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial | Lancet Oncology, The | 2013 | 280 |
| 18 | Desktop-stereolithography 3D printing of a radially oriented extracellular matrix/mesenchymal stem cell exosome bioink for osteochondral defect regeneration | Theranostics | 2019 | 280 |
| 19 | Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005–2014 | Clinical Microbiology and Infection | 2016 | 274 |
| 20 | MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges | BioMed Research International | 2015 | 251 |
| 21 | Age-related hearing loss or presbycusis | European Archives of Oto-Rhino-Laryngology | 2010 | 250 |
| 22 | Acute‐on‐chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults | Hepatology | 2015 | 248 |
| 23 | Lactose Intolerance in Adults: Biological Mechanism and Dietary Management | Nutrients | 2015 | 245 |
| 24 | Migration of Endothelial Progenitor Cells Mediated by Stromal Cell-Derived Factor-1α/CXCR4 via PI3K/Akt/eNOS Signal Transduction Pathway | Journal of Cardiovascular Pharmacology | 2007 | 243 |
| 25 | Multifidus muscle changes and clinical effects of one-level posterior lumbar interbody fusion: minimally invasive procedure versus conventional open approach | European Spine Journal | 2010 | 242 |
| 26 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial | European Journal of Cancer | 2012 | 240 |
| 27 | Emergence of NDM-1-producing Acinetobacter baumannii in China | Journal of Antimicrobial Chemotherapy | 2011 | 225 |
| 28 | Coronavirus 2019-nCoV: A brief perspective from the front line | Journal of Infection | 2020 | 225 |
| 29 | Minimally Invasive Transforaminal Lumbar Interbody Fusion for the Treatment of Degenerative Lumbar Diseases | Spine | 2010 | 220 |
| 30 | Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches | Oncogene | 2017 | 219 |
| 31 | Oxidative stress in the pathogenesis of psoriasis | Free Radical Biology and Medicine | 2009 | 218 |
| 32 | EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells | PLoS ONE | 2011 | 217 |
| 33 | In situ endothelialization of intravascular stents coated with an anti-CD34 antibody functionalized heparin–collagen multilayer | Biomaterials | 2010 | 215 |
| 34 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study) | Gastric Cancer | 2015 | 209 |
| 35 | Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model | Frontiers in Microbiology | 2017 | 209 |
| 36 | A pre-trained convolutional neural network based method for thyroid nodule diagnosis | Ultrasonics | 2017 | 207 |
| 37 | Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease | ACS Nano | 2018 | 205 |
| 38 | Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis | Biomaterials | 2020 | 205 |
| 39 | Nitric oxide as an all-rounder for enhanced photodynamic therapy: Hypoxia relief, glutathione depletion and reactive nitrogen species generation | Biomaterials | 2018 | 191 |
| 40 | Ligament regeneration using a knitted silk scaffold combined with collagen matrix | Biomaterials | 2008 | 190 |
| 41 | Roles of PFKFB3 in cancer | Signal Transduction and Targeted Therapy | 2017 | 189 |
| 42 | The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease | Toxicology Letters | 2012 | 188 |
| 43 | Pyrotinib plus capecitabine versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): a multicentre, open-label, randomised, controlled, phase 3 trial | Lancet Oncology, The | 2021 | 188 |
| 44 | Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies | Journal of the American Chemical Society | 2018 | 182 |
| 45 | The 14 bp deletion polymorphisms in HLA‐G gene play an important role in the expression of soluble HLA‐G in plasma | Tissue Antigens | 2008 | 178 |
| 46 | Cardiac Resynchronization Therapy in Patients With Nonischemic Cardiomyopathy Using Left Bundle Branch Pacing | JACC: Clinical Electrophysiology | 2020 | 178 |
| 47 | Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study | Lancet Infectious Diseases, The | 2017 | 177 |
| 48 | Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects | Free Radical Biology and Medicine | 2019 | 177 |
| 49 | Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial | Lancet, The | 2021 | 175 |
| 50 | Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness | Cell Death and Disease | 2019 | 174 |
