| # | Title | Journal | Year | Citations |
|---|
| 1 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 2 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 3 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 4 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 5 | Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis | Lancet Respiratory Medicine,the | 2019 | 1,866 |
| 6 | Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis | The Lancet Global Health | 2019 | 1,839 |
| 7 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 8 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 9 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 10 | Hypovitaminosis D in Medical Inpatients | New England Journal of Medicine | 1998 | 1,322 |
| 11 | Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial | Lancet, The | 2015 | 1,175 |
| 12 | Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study | Lancet, The | 2020 | 1,108 |
| 13 | PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma | New England Journal of Medicine | 2018 | 997 |
| 14 | Advances in Malignant Mesothelioma | New England Journal of Medicine | 2005 | 996 |
| 15 | Celecoxib for the Prevention of Sporadic Colorectal Adenomas | New England Journal of Medicine | 2006 | 964 |
| 16 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 17 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 18 | Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging | Neurobiology of Aging | 2010 | 885 |
| 19 | Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial | Lancet Oncology, The | 2005 | 876 |
| 20 | Association of sleep apnoea with myocardial infarction in men | Lancet, The | 1990 | 856 |
| 21 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 22 | A genome-wide search for quantitative trait loci underlying asthma | Nature | 1996 | 750 |
| 23 | Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease | Journal of the American College of Cardiology | 2013 | 749 |
| 24 | Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways | Nature Genetics | 2012 | 746 |
| 25 | Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial | Lancet, The | 2014 | 740 |
| 26 | Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04 | Journal of Clinical Oncology | 2012 | 725 |
| 27 | Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction | Nature Genetics | 2009 | 709 |
| 28 | The Structure of Large and Small Airways in Nonfatal and Fatal Asthma | The American Review of Respiratory Disease | 1993 | 685 |
| 29 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial | Lancet, The | 2010 | 677 |
| 30 | Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma | American Journal of Respiratory and Critical Care Medicine | 2010 | 650 |
| 31 | The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma | Nature Genetics | 2011 | 617 |
| 32 | Modified RECIST criteria for assessment of response in malignant pleural mesothelioma | Annals of Oncology | 2004 | 561 |
| 33 | Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study | Annals of Oncology | 2017 | 549 |
| 34 | Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study | Gastroenterology | 2018 | 536 |
| 35 | Prevention of Postmenopausal Osteoporosis | New England Journal of Medicine | 1991 | 533 |
| 36 | Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data | BMJ, The | 2014 | 528 |
| 37 | Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer | Lancet, The | 2000 | 521 |
| 38 | Randomized Trial of a Hypofractionated Radiation Regimen for the Treatment of Localized Prostate Cancer | Journal of Clinical Oncology | 2017 | 521 |
| 39 | Genome-wide association study identifies five loci associated with lung function | Nature Genetics | 2010 | 518 |
| 40 | Mesothelin-family proteins and diagnosis of mesothelioma | Lancet, The | 2003 | 516 |
| 41 | Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial | Lancet, The | 2016 | 509 |
| 42 | Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 | Nature Genetics | 2009 | 501 |
| 43 | Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture | Nature | 2015 | 483 |
| 44 | Hepascore: An Accurate Validated Predictor of Liver Fibrosis in Chronic Hepatitis C Infection | Clinical Chemistry | 2005 | 482 |
| 45 | Randomised trial of SIR-Spheres® plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer | Annals of Oncology | 2001 | 476 |
| 46 | The airway epithelium: Structural and functional properties in health and disease | Respirology | 2003 | 476 |
| 47 | Preoperative Assessment as a Predictor of Mortality and Morbidity after Lung Resection | The American Review of Respiratory Disease | 1989 | 441 |
| 48 | Subclinical Thyroid Dysfunction as a Risk Factor for Cardiovascular Disease | Archives of Internal Medicine | 2005 | 436 |
| 49 | Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma | Blood | 2011 | 428 |
| 50 | Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks | Nature Genetics | 2018 | 426 |
