| # | Title | Journal | Year | Citations |
|---|
| 1 | SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls | Nature | 2020 | 1,744 |
| 2 | Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore | JAMA - Journal of the American Medical Association | 2020 | 1,700 |
| 3 | Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia | New England Journal of Medicine | 2007 | 1,613 |
| 4 | The landscape of cancer genes and mutational processes in breast cancer | Nature | 2012 | 1,535 |
| 5 | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | Nature Genetics | 2008 | 1,286 |
| 6 | The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: A tool for distinguishing necrotizing fasciitis from other soft tissue infections* | Critical Care Medicine | 2004 | 1,175 |
| 7 | Nipah Virus: A Recently Emergent Deadly Paramyxovirus | Science | 2000 | 1,079 |
| 8 | Continuous renal replacement therapy: A worldwide practice survey | Intensive Care Medicine | 2007 | 1,020 |
| 9 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 10 | Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome | Lancet, The | 2003 | 956 |
| 11 | Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma | Hepatology International | 2010 | 944 |
| 12 | A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias | New England Journal of Medicine | 2013 | 944 |
| 13 | Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates | Nature | 2018 | 942 |
| 14 | Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors | Nature Genetics | 2017 | 849 |
| 15 | STOP-Bang Questionnaire | Chest | 2016 | 824 |
| 16 | Validity and reliability of the Nintendo Wii Balance Board for assessment of standing balance | Gait and Posture | 2010 | 811 |
| 17 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 18 | Peritoneal carcinomatosis from colorectal cancer | British Journal of Surgery | 2002 | 749 |
| 19 | Can We Apply the National Cholesterol Education Program Adult Treatment Panel Definition of the Metabolic Syndrome to Asians? | Diabetes Care | 2004 | 729 |
| 20 | Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial | Lancet Oncology, The | 2014 | 695 |
| 21 | Mechanisms of diabetes mellitus-induced bone fragility | Nature Reviews Endocrinology | 2017 | 678 |
| 22 | Emergence and global spread of epidemic healthcare-associated Clostridium difficile | Nature Genetics | 2013 | 669 |
| 23 | Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B | Gastroenterology | 2000 | 668 |
| 24 | Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project | Blood | 2009 | 656 |
| 25 | Breast cancer prognostic classification in the molecular era: the role of histological grade | Breast Cancer Research | 2010 | 650 |
| 26 | Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells | Immunity | 2012 | 643 |
| 27 | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations | Nature Genetics | 2008 | 641 |
| 28 | Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma | Cancer Discovery | 2017 | 637 |
| 29 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study | Gastroenterology | 2013 | 633 |
| 30 | Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-Year Analysis of Susceptibilities of Candida Species to Fluconazole and Voriconazole as Determined by CLSI Standardized Disk Diffusion | Journal of Clinical Microbiology | 2010 | 567 |
| 31 | Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy | Hepatology | 2001 | 565 |
| 32 | Validity of the Microsoft Kinect for assessment of postural control | Gait and Posture | 2012 | 564 |
| 33 | A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets | Gut | 2012 | 562 |
| 34 | Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes | Nature Genetics | 2012 | 560 |
| 35 | Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists | Modern Pathology | 2011 | 545 |
| 36 | Simulation-based learning: Just like the real thing | Journal of Emergencies, Trauma and Shock | 2010 | 521 |
| 37 | Immunogenicity of engineered antibodies | Methods | 2005 | 519 |
| 38 | Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore | Canadian Journal of Anaesthesia | 2020 | 518 |
| 39 | A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer | Nature Medicine | 2012 | 510 |
| 40 | Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum | Nature Communications | 2015 | 486 |
| 41 | An Update on the Epidemiology of Inflammatory Bowel Disease in Asia | American Journal of Gastroenterology | 2008 | 474 |
| 42 | SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma | Journal of Clinical Oncology | 2018 | 467 |
| 43 | Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage | Nature Genetics | 2015 | 466 |
| 44 | Parkinson’s disease: etiopathogenesis and treatment | Journal of Neurology, Neurosurgery and Psychiatry | 2020 | 459 |
| 45 | Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions | Immunity | 2018 | 450 |
| 46 | Subtrochanteric insufficiency fractures in patients on alendronate therapy | Journal of Bone and Joint Surgery: British Volume | 2007 | 448 |
| 47 | Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial | Lancet Oncology, The | 2011 | 444 |
| 48 | Mapping the human DC lineage through the integration of high-dimensional techniques | Science | 2017 | 429 |
| 49 | Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers | Nature Genetics | 2013 | 426 |
| 50 | Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection | Lancet, The | 2003 | 423 |
