| # | Title | Journal | Year | Citations |
|---|
| 1 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA | Journal of Molecular Evolution | 1985 | 7,690 |
| 2 | The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity | Nature Medicine | 2001 | 4,370 |
| 3 | Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families | Endocrine Reviews | 1999 | 2,009 |
| 4 | IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis | Journal of Clinical Investigation | 1999 | 1,479 |
| 5 | Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713] | Journal of Cell Biology | 1994 | 1,364 |
| 6 | Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction | Journal of Experimental Medicine | 2000 | 1,219 |
| 7 | Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 917 |
| 8 | OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION | Endocrinology | 1988 | 909 |
| 9 | Mortality Risk for Dialysis Patients With Different Levels of Serum Calcium, Phosphorus, and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS) | American Journal of Kidney Diseases | 2008 | 888 |
| 10 | IL-6 is produced by osteoblasts and induces bone resorption. | Journal of Immunology | 1990 | 883 |
| 11 | Elevated Levels of C-Reactive Protein and Interleukin-6 in Patients With Obstructive Sleep Apnea Syndrome Are Decreased by Nasal Continuous Positive Airway Pressure | Circulation | 2003 | 873 |
| 12 | Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2 | Journal of Biological Chemistry | 2000 | 838 |
| 13 | Update on the Paris Classification of Superficial Neoplastic Lesions in the Digestive Tract | Endoscopy | 2005 | 806 |
| 14 | Modulation of Osteoclast Differentiation | Endocrine Reviews | 1992 | 783 |
| 15 | IL-6 is produced by osteoblasts and induces bone resorption | Journal of Immunology | 1990 | 780 |
| 16 | Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 778 |
| 17 | LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death | Molecular Cell | 2002 | 746 |
| 18 | Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma | Journal of Biochemistry | 1996 | 743 |
| 19 | Osteoclast-Like Cell Formation and its Regulation by Osteotropic Hormones in Mouse Bone Marrow Cultures* | Endocrinology | 1988 | 716 |
| 20 | Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. | Journal of Cell Biology | 1991 | 716 |
| 21 | Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population | Diabetes | 2002 | 668 |
| 22 | Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche | Cell | 2011 | 654 |
| 23 | Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis | Journal of Biological Chemistry | 2000 | 643 |
| 24 | Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble ?-synuclein | Annals of Neurology | 1998 | 633 |
| 25 | Phospholipase A2 enzymes | Prostaglandins and Other Lipid Mediators | 2002 | 632 |
| 26 | Activated human T cells directly induce osteoclastogenesis from human monocytes: Possible role of T cells in bone destruction in rheumatoid arthritis patients | Arthritis and Rheumatism | 2001 | 577 |
| 27 | Regulation of Osteoblast Differentiation Mediated by Bone Morphogenetic Proteins, Hedgehogs, and Cbfa1 | Endocrine Reviews | 2000 | 572 |
| 28 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal | Journal of Gastroenterology | 2006 | 549 |
| 29 | Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan: GEST Study | Journal of Clinical Oncology | 2013 | 548 |
| 30 | Effect of Matching of Class I HLA Alleles on Clinical Outcome after Transplantation of Hematopoietic Stem Cells from an Unrelated Donor | New England Journal of Medicine | 1998 | 534 |
| 31 | TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration | Nature Medicine | 2008 | 526 |
| 32 | Frequent inactivation of A20 in B-cell lymphomas | Nature | 2009 | 520 |
| 33 | A practical method for position-dependent Compton-scatter correction in single photon emission CT | IEEE Transactions on Medical Imaging | 1991 | 517 |
| 34 | Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. | Journal of Clinical Investigation | 1993 | 511 |
| 35 | Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos | Journal of Biological Chemistry | 2004 | 509 |
| 36 | Regulatory mechanisms of osteoblast and osteoclast differentiation | Oral Diseases | 2002 | 496 |
| 37 | The Bone Marrow-Derived Stromal Cell Lines MC3T3-G2/PA6 and ST2 Support Osteoclast-Like Cell Differentiation in Cocultures with Mouse Spleen Cells | Endocrinology | 1989 | 482 |
| 38 | COPD in Japan: the Nippon COPD Epidemiology study | Respirology | 2004 | 482 |
| 39 | Nitric oxide activates TRP channels by cysteine S-nitrosylation | | 2006 | 480 |
| 40 | 1α,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells | Biochemical and Biophysical Research Communications | 1981 | 479 |
| 41 | Regulatory Functions of Phospholipase A2 | Critical Reviews in Immunology | 1997 | 479 |
| 42 | The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2 | Biochemical and Biophysical Research Communications | 1990 | 477 |
| 43 | Reliability and validity of Japanese version of the Mini‐International Neuropsychiatric Interview | Psychiatry and Clinical Neurosciences | 2005 | 475 |
| 44 | Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine | Journal of Neuroscience | 2006 | 471 |
| 45 | Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation | Journal of Bone and Mineral Research | 1996 | 465 |
| 46 | Nonpolypoid neoplastic lesions of the colorectal mucosa | Gastrointestinal Endoscopy | 2008 | 457 |
| 47 | Phospholipase A2 | Journal of Biochemistry | 2002 | 453 |
| 48 | Per-Oral Endoscopic Myotomy: A Series of 500 Patients | Journal of the American College of Surgeons | 2015 | 435 |
| 49 | Phase II Study of S-1, a Novel Oral Derivative of 5-Fluorouracil, in Advanced Gastric Cancer | Oncology | 2000 | 433 |
| 50 | A New Member of Tumor Necrosis Factor Ligand Family, ODF/OPGL/TRANCE/RANKL, Regulates Osteoclast Differentiation and Function | Biochemical and Biophysical Research Communications | 1999 | 410 |
