| # | Title | Journal | Year | Citations |
|---|
| 1 | Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele | Nature | 1996 | 3,776 |
| 2 | A human colon cancer cell capable of initiating tumour growth in immunodeficient mice | Nature | 2007 | 3,765 |
| 3 | Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice | Nature | 1995 | 3,666 |
| 4 | Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry | Nature | 2002 | 3,445 |
| 5 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes | Lancet, The | 2006 | 3,287 |
| 6 | The ground state of embryonic stem cell self-renewal | Nature | 2008 | 3,057 |
| 7 | Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy | Diabetes Care | 2009 | 2,988 |
| 8 | Biology of Incretins: GLP-1 and GIP | Gastroenterology | 2007 | 2,918 |
| 9 | Protein modules and signalling networks | Nature | 1995 | 2,459 |
| 10 | Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium | Nature | 1995 | 2,423 |
| 11 | Signaling Through Scaffold, Anchoring, and Adaptor Proteins | Science | 1997 | 2,168 |
| 12 | SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins | Science | 1991 | 1,988 |
| 13 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 14 | Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer | New England Journal of Medicine | 2003 | 1,962 |
| 15 | The Genetic Landscape of a Cell | Science | 2010 | 1,937 |
| 16 | piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells | Nature | 2009 | 1,662 |
| 17 | Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes | New England Journal of Medicine | 2017 | 1,455 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 19 | Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles | Molecular Cell | 2015 | 1,408 |
| 20 | Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family | Cell | 2012 | 1,368 |
| 21 | VEGF Inhibition and Renal Thrombotic Microangiopathy | New England Journal of Medicine | 2008 | 1,348 |
| 22 | The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus | Nature | 1988 | 1,326 |
| 23 | Assembly of Cell Regulatory Systems Through Protein Interaction Domains | Science | 2003 | 1,310 |
| 24 | Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2 | European Urology | 2019 | 1,270 |
| 25 | Implantation and the placenta: key pieces of the development puzzle | Science | 1994 | 1,259 |
| 26 | Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer | New England Journal of Medicine | 2000 | 1,235 |
| 27 | Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo | Cell | 1998 | 1,224 |
| 28 | Promotion of Trophoblast Stem Cell Proliferation by FGF4 | | 1998 | 1,221 |
| 29 | Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation | Molecular Cell | 2000 | 1,219 |
| 30 | Normalization of obesity-associated insulin resistance through immunotherapy | Nature Medicine | 2009 | 1,217 |
| 31 | Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death | Nature | 2001 | 1,212 |
| 32 | Virus-free induction of pluripotency and subsequent excision of reprogramming factors | Nature | 2009 | 1,200 |
| 33 | Cardiac malformation in neonatal mice lacking connexin43 | Science | 1995 | 1,195 |
| 34 | A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 | Nature | 2008 | 1,169 |
| 35 | F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex | Cell | 1997 | 1,166 |
| 36 | Tidal ventilation at low airway pressures can augment lung injury. | American Journal of Respiratory and Critical Care Medicine | 1994 | 1,149 |
| 37 | Placental development: Lessons from mouse mutants | Nature Reviews Genetics | 2001 | 1,135 |
| 38 | Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration | Cell | 2012 | 1,112 |
| 39 | Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action | Cell Metabolism | 2013 | 1,088 |
| 40 | Obesity-associated variants within FTO form long-range functional connections with IRX3 | Nature | 2014 | 1,079 |
| 41 | Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation | Cell | 2005 | 1,062 |
| 42 | Distinct endocytic pathways regulate TGF-β receptor signalling and turnover | Nature Cell Biology | 2003 | 1,048 |
| 43 | The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 | Nature | 1993 | 1,047 |
| 44 | β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB | Cell | 2002 | 1,039 |
| 45 | SH2 and SH3 domains: From structure to function | Cell | 1992 | 1,020 |
| 46 | Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases | Nature | 1992 | 1,009 |
| 47 | Function of PI3K in Thymocyte Development, T Cell Activation, and Neutrophil Migration | Science | 2000 | 1,003 |
| 48 | Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance | Neuron | 2015 | 992 |
| 49 | Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons | Cell | 1993 | 989 |
| 50 | A global genetic interaction network maps a wiring diagram of cellular function | Science | 2016 | 979 |
