| # | Title | Journal | Year | Citations |
|---|
| 1 | Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China | JAMA Internal Medicine | 2020 | 6,424 |
| 2 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases | Cell Research | 2008 | 4,084 |
| 3 | Prevalence of chronic kidney disease in China: a cross-sectional survey | Lancet, The | 2012 | 1,643 |
| 4 | Effectiveness of convalescent plasma therapy in severe COVID-19 patients | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 1,601 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention | Nature Medicine | 2017 | 1,074 |
| 7 | The gut microbiome in atherosclerotic cardiovascular disease | Nature Communications | 2017 | 1,029 |
| 8 | The J-Curve Phenomenon in Hypertension | Pulse | 2016 | 1,020 |
| 9 | CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer | Nucleic Acids Research | 2010 | 905 |
| 10 | Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation | Immunity | 2011 | 887 |
| 11 | Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial | BMJ, The | 2020 | 811 |
| 12 | Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study | Lancet, The | 2007 | 766 |
| 13 | Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations | Cell Discovery | 2020 | 717 |
| 14 | COVID-19 with Different Severities: A Multicenter Study of Clinical Features | American Journal of Respiratory and Critical Care Medicine | 2020 | 690 |
| 15 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients | Chinese Medical Journal | 2020 | 686 |
| 16 | A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension | Lancet, The | 2016 | 670 |
| 17 | Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure | Circulation Research | 2016 | 664 |
| 18 | Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China | JAMA - Journal of the American Medical Association | 2015 | 577 |
| 19 | Estimation of the reproductive number of novel coronavirus (COVID-19) and the probable outbreak size on the Diamond Princess cruise ship: A data-driven analysis | International Journal of Infectious Diseases | 2020 | 557 |
| 20 | Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice | Stem Cells | 2014 | 550 |
| 21 | Genome-wide association study identifies susceptibility loci for IgA nephropathy | Nature Genetics | 2011 | 528 |
| 22 | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens | Nature Genetics | 2014 | 505 |
| 23 | Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis | Cancer Research | 2018 | 481 |
| 24 | Effect of Laparoscopic vs Open Distal Gastrectomy on 3-Year Disease-Free Survival in Patients With Locally Advanced Gastric Cancer | JAMA - Journal of the American Medical Association | 2019 | 477 |
| 25 | Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine | Journal of Clinical Endocrinology and Metabolism | 2008 | 470 |
| 26 | Comparative Proteomic Analysis Provides New Insights into Chilling Stress Responses in Rice | Molecular and Cellular Proteomics | 2006 | 467 |
| 27 | Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer | Oncotarget | 2014 | 467 |
| 28 | Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet Oncology, The | 2014 | 434 |
| 29 | Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21 | Nature Genetics | 2009 | 410 |
| 30 | Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome–positive chronic myeloid leukemia patients with resistance or intolerance to imatinib | Blood | 2011 | 406 |
| 31 | Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial | Lancet Oncology, The | 2013 | 389 |
| 32 | Meta-analysis identifies common variants associated with body mass index in east Asians | Nature Genetics | 2012 | 372 |
| 33 | Berberine activates thermogenesis in white and brown adipose tissue | Nature Communications | 2014 | 367 |
| 34 | Minimally Invasive Surgery and the Novel Coronavirus Outbreak: Lessons Learned in China and Italy | Annals of Surgery | 2020 | 364 |
| 35 | ICEberg 2.0: an updated database of bacterial integrative and conjugative elements | Nucleic Acids Research | 2019 | 363 |
| 36 | Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig | Nature Communications | 2020 | 358 |
| 37 | Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer | Clinical Chemistry | 2012 | 350 |
| 38 | Incidence and Etiology of Drug-Induced Liver Injury in Mainland China | Gastroenterology | 2019 | 346 |
| 39 | Vascularized 3D printed scaffolds for promoting bone regeneration | Biomaterials | 2019 | 345 |
| 40 | Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway | Nature Genetics | 2014 | 343 |
| 41 | METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST | Molecular Cancer | 2020 | 336 |
| 42 | Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity | Journal of Biological Chemistry | 2004 | 329 |
| 43 | Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment | Frontiers in Immunology | 2020 | 328 |
| 44 | Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score | Frontiers in Microbiology | 2019 | 326 |
| 45 | The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021 | Cancer Communications | 2021 | 323 |
| 46 | Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations | Journal of Hypertension | 2010 | 318 |
| 47 | Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China | Journal of the American Society of Nephrology: JASN | 2016 | 316 |
| 48 | Association between age and clinical characteristics and outcomes of COVID-19 | European Respiratory Journal | 2020 | 316 |
| 49 | Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment | Nature Communications | 2017 | 312 |
| 50 | Ambulatory Arterial Stiffness Index Derived From 24-Hour Ambulatory Blood Pressure Monitoring | Hypertension | 2006 | 307 |
