| # | Title | Journal | Year | Citations |
|---|
| 1 | Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II | Addiction | 1993 | 10,134 |
| 2 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery | Journal of the American College of Cardiology | 2002 | 3,941 |
| 3 | Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials | Physical Therapy | 2003 | 3,431 |
| 4 | CpG Islands in vertebrate genomes | Journal of Molecular Biology | 1987 | 3,038 |
| 5 | A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 2,871 |
| 6 | Updated Clinical Classification of Pulmonary Hypertension | Journal of the American College of Cardiology | 2013 | 2,865 |
| 7 | Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma | New England Journal of Medicine | 2019 | 2,594 |
| 8 | International uniform response criteria for multiple myeloma | Leukemia | 2006 | 2,332 |
| 9 | Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee | Clinical Neurophysiology | 2015 | 1,957 |
| 10 | Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response | Nature Medicine | 2006 | 1,865 |
| 11 | High sensitivity mapping of methylated cytosines | Nucleic Acids Research | 1994 | 1,749 |
| 12 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS) | Surgery | 2011 | 1,703 |
| 13 | Melanoma staging: Evidence‐based changes in the American Joint Committee on Cancer eighth edition cancer staging manual | Ca-A Cancer Journal for Clinicians | 2017 | 1,662 |
| 14 | Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery | Surgery | 2011 | 1,596 |
| 15 | Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care | New England Journal of Medicine | 2012 | 1,460 |
| 16 | Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome | JAMA - Journal of the American Medical Association | 2009 | 1,416 |
| 17 | Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials | Lancet Oncology, The | 2015 | 1,369 |
| 18 | A Clinical Sign of Canal Paresis | Archives of Neurology | 1988 | 1,167 |
| 19 | Frequency of Depression After Stroke | Stroke | 2005 | 1,116 |
| 20 | Whole-genome landscapes of major melanoma subtypes | Nature | 2017 | 1,068 |
| 21 | Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006) | Lancet, The | 2017 | 1,032 |
| 22 | Human Papillomavirus and Oral Cancer: The International Agency for Research on Cancer Multicenter Study | Journal of the National Cancer Institute | 2003 | 1,013 |
| 23 | Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action | Diabetes | 1997 | 1,006 |
| 24 | Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis | Lancet, The | 2011 | 987 |
| 25 | Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer | New England Journal of Medicine | 2019 | 982 |
| 26 | Prognostic and Clinicopathologic Associations of Oncogenic BRAF in Metastatic Melanoma | Journal of Clinical Oncology | 2011 | 942 |
| 27 | A BLINDED, RANDOMIZED CLINICAL TRIAL OF MYCOPHENOLATE MOFETIL FOR THE PREVENTION OF ACUTE REJECTION IN CADAVERIC RENAL TRANSPLANTATION1 | Transplantation | 1996 | 933 |
| 28 | Gamma Glutamyl Transferase | Critical Reviews in Clinical Laboratory Sciences | 2001 | 893 |
| 29 | A systematic review of physicians' survival predictions in terminally ill cancer patients | BMJ: British Medical Journal | 2003 | 864 |
| 30 | Passive Smoking and Impaired Endothelium-Dependent Arterial Dilatation in Healthy Young Adults | New England Journal of Medicine | 1996 | 858 |
| 31 | Effect of Laparoscopic-Assisted Resection vs Open Resection on Pathological Outcomes in Rectal Cancer | JAMA - Journal of the American Medical Association | 2015 | 835 |
| 32 | Methicillin-resistant Staphylococcus aureus | Nature Reviews Disease Primers | 2018 | 833 |
| 33 | Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study | Lancet Oncology, The | 2019 | 812 |
| 34 | A Controlled Trial of Long-Term Inhaled Hypertonic Saline in Patients with Cystic Fibrosis | New England Journal of Medicine | 2006 | 791 |
| 35 | Obesity Hypoventilation Syndrome | American Journal of Respiratory and Critical Care Medicine | 2011 | 789 |
| 36 | Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma | Leukemia | 2008 | 787 |
| 37 | Systematic Review and Meta-Analysis of Randomized and Nonrandomized Trials on Safety and Efficacy of Video-Assisted Thoracic Surgery Lobectomy for Early-Stage Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2009 | 729 |
| 38 | Endoleak as a Complication of Endoluminal Grafting of Abdominal Aortic Aneurysms: Classification, Incidence, Diagnosis,and Management | Journal of Endovascular Therapy | 1997 | 726 |
| 39 | Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study | Lancet Oncology, The | 2016 | 723 |
| 40 | Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma | Cell | 2012 | 688 |
| 41 | International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders | Leukemia | 2009 | 686 |
| 42 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression | Gastroenterology | 2003 | 681 |
| 43 | Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. | American Journal of Respiratory and Critical Care Medicine | 1996 | 671 |
| 44 | Prospective Study of the Impact of Fear of Falling on Activities of Daily Living, SF-36 Scores, and Nursing Home Admission | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2000 | 663 |
| 45 | Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting | British Journal of Dermatology | 2008 | 628 |
| 46 | Long-term outcome in congenitally corrected transposition of the great arteries | Journal of the American College of Cardiology | 2000 | 616 |
| 47 | PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2015 | 615 |
| 48 | Endothelial Dysfunction: Does It Matter? Is It Reversible? | Journal of the American College of Cardiology | 1997 | 599 |
| 49 | Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma: Multi-Institutional Experience | Journal of Clinical Oncology | 2009 | 598 |
| 50 | Binding proteins for the insulin-like growth factors: Structure, regulation and function | Progress in Growth Factor Research | 1989 | 569 |
