| # | Title | Journal | Year | Citations |
|---|
| 1 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase | Gene | 1988 | 6,310 |
| 2 | Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials | Lancet, The | 2016 | 5,331 |
| 3 | Dementia prevention, intervention, and care: 2020 report of the Lancet Commission | Lancet, The | 2020 | 4,658 |
| 4 | Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies | Science Translational Medicine | 2014 | 3,665 |
| 5 | Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation | Circulation: Arrhythmia and Electrophysiology | 2010 | 1,962 |
| 6 | Hyaluronan 1 | FASEB Journal | 1992 | 1,911 |
| 7 | Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells | Nature | 1988 | 1,871 |
| 8 | Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock | New England Journal of Medicine | 2008 | 1,711 |
| 9 | Clinical applications of visual analogue scales: a critical review | Psychological Medicine | 1988 | 1,646 |
| 10 | The vascular territories (angiosomes) of the body: experimental study and clinical applications | Journal of Plastic, Reconstructive and Aesthetic Surgery | 1987 | 1,620 |
| 11 | The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro | Antiviral Research | 2020 | 1,567 |
| 12 | Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2016 | 1,532 |
| 13 | Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers | Nature Medicine | 2009 | 1,261 |
| 14 | Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,261 |
| 15 | Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial | Lancet Oncology, The | 2014 | 1,237 |
| 16 | 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design | Journal of Interventional Cardiac Electrophysiology | 2012 | 1,167 |
| 17 | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours | Journal of Pathology | 2014 | 1,151 |
| 18 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics | Nature Medicine | 2001 | 1,113 |
| 19 | Proteoglycans: many forms and many functions | FASEB Journal | 1992 | 1,101 |
| 20 | Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 1,078 |
| 21 | KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors | New England Journal of Medicine | 2020 | 1,049 |
| 22 | The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells | Nature | 1989 | 1,036 |
| 23 | Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. | Genes and Development | 1995 | 1,018 |
| 24 | Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage | Neurology | 2006 | 992 |
| 25 | Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial | Lancet Oncology, The | 2017 | 975 |
| 26 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial | Lancet Neurology, The | 2008 | 971 |
| 27 | The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex | Molecular Cell | 1999 | 964 |
| 28 | Celecoxib for the Prevention of Sporadic Colorectal Adenomas | New England Journal of Medicine | 2006 | 964 |
| 29 | Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo* | British Journal of Haematology | 1970 | 962 |
| 30 | Systematic Review and Meta-analysis of Studies Reporting Urinary Continence Recovery After Robot-assisted Radical Prostatectomy | European Urology | 2012 | 961 |
| 31 | Use of staphylococcal protein A as an immunological reagent | Journal of Immunological Methods | 1978 | 956 |
| 32 | Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow | Journal of Cell Science | 2003 | 949 |
| 33 | Exosomes: proteomic insights and diagnostic potential | Expert Review of Proteomics | 2009 | 935 |
| 34 | The molecular biology of apoptosis. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 907 |
| 35 | Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2 | Nature | 1990 | 873 |
| 36 | Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy | Lancet, The | 1992 | 872 |
| 37 | gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis | Cancer Cell | 2009 | 852 |
| 38 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial | Lancet, The | 2011 | 849 |
| 39 | Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 815 |
| 40 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study | Lancet, The | 2006 | 802 |
| 41 | 2017 HRS expert consensus statement on cardiovascular implantable electronic device lead management and extraction | Heart Rhythm | 2017 | 792 |
| 42 | An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors | Molecular Cell | 2003 | 774 |
| 43 | Common genetic variants influence human subcortical brain structures | Nature | 2015 | 772 |
| 44 | Proteomic profiling of exosomes: Current perspectives | Proteomics | 2008 | 767 |
| 45 | Negative selection of lymphocytes | Cell | 1994 | 757 |
| 46 | An evolutionary perspective on apoptosis | Cell | 1994 | 757 |
| 47 | Long-Term Effect of Goal-Directed Weight Management in an Atrial Fibrillation Cohort | Journal of the American College of Cardiology | 2015 | 738 |
| 48 | Aggressive Risk Factor Reduction Study for Atrial Fibrillation and Implications for the Outcome of Ablation | Journal of the American College of Cardiology | 2014 | 737 |
| 49 | Aspirin in Patients Undergoing Noncardiac Surgery | New England Journal of Medicine | 2014 | 735 |
| 50 | Lymphangiogenesis and cancer metastasis | Nature Reviews Cancer | 2002 | 729 |
