| # | Title | Journal | Year | Citations |
|---|
| 1 | Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance | Clinical Microbiology and Infection | 2012 | 8,996 |
| 2 | Patterns of somatic mutation in human cancer genomes | Nature | 2007 | 2,802 |
| 3 | Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society | Clinical Infectious Diseases | 2016 | 2,405 |
| 4 | Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | Nature Genetics | 2009 | 2,155 |
| 5 | The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years | Hepatology | 1990 | 1,354 |
| 6 | Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases | Lancet Infectious Diseases, The | 2013 | 1,328 |
| 7 | Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,261 |
| 8 | Association between insulin resistance and the development of cardiovascular disease | Cardiovascular Diabetology | 2018 | 1,031 |
| 9 | Cellular and Molecular Mechanisms of Bone Remodeling | Journal of Biological Chemistry | 2010 | 993 |
| 10 | Intragenic ERBB2 kinase mutations in tumours | Nature | 2004 | 757 |
| 11 | Pharmacokinetic issues for antibiotics in the critically ill patient | Critical Care Medicine | 2009 | 755 |
| 12 | Common variants associated with plasma triglycerides and risk for coronary artery disease | Nature Genetics | 2013 | 754 |
| 13 | Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions | Lancet Infectious Diseases, The | 2014 | 745 |
| 14 | Time-resolved resting-state brain networks | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 716 |
| 15 | Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs | Blood | 2010 | 695 |
| 16 | OMERACT-OARSI Initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. | Osteoarthritis and Cartilage | 2004 | 683 |
| 17 | Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis | Hepatology | 1986 | 670 |
| 18 | Effectiveness of brief alcohol interventions in primary care populations | The Cochrane Library | 2007 | 664 |
| 19 | Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients | Antimicrobial Agents and Chemotherapy | 2011 | 626 |
| 20 | Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164 | Journal of Clinical Oncology | 2020 | 623 |
| 21 | Disrupted hepcidin regulation in HFE -associated haemochromatosis and the liver as a regulator of body iron homoeostasis | Lancet, The | 2003 | 568 |
| 22 | Effectiveness of brief alcohol interventions in primary care populations | The Cochrane Library | 2018 | 568 |
| 23 | [177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial | Lancet, The | 2021 | 552 |
| 24 | Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists | Modern Pathology | 2011 | 545 |
| 25 | Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study | Lancet, The | 2016 | 539 |
| 26 | The prevalence and impact of overweight and obesity in an Australian obstetric population | Medical Journal of Australia | 2006 | 536 |
| 27 | Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy | Nature Genetics | 2002 | 526 |
| 28 | Targeted therapy for non-small cell lung cancer: current standards and the promise of the future | Translational Lung Cancer Research | 2015 | 499 |
| 29 | Modulating the stem cell niche for tissue regeneration | Nature Biotechnology | 2014 | 492 |
| 30 | Apparent Fibre Density: A novel measure for the analysis of diffusion-weighted magnetic resonance images | NeuroImage | 2012 | 491 |
| 31 | Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome | Movement Disorders | 2004 | 488 |
| 32 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome | Diabetes Care | 2009 | 488 |
| 33 | Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations | Journal of Physiotherapy | 2020 | 481 |
| 34 | Crohn's disease management after intestinal resection: a randomised trial | Lancet, The | 2015 | 475 |
| 35 | Interaction between ATM protein and c-Abl in response to DNA damage | Nature | 1997 | 460 |
| 36 | Internucleosomal DNA Cleavage Should not be the Sole Criterion for Identifying Apoptosis | International Journal of Radiation Biology | 1992 | 452 |
| 37 | Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study | Journal of Clinical Oncology | 2020 | 450 |
| 38 | Predictors of future falls in Parkinson disease | Neurology | 2010 | 443 |
| 39 | Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours | Nature Genetics | 1996 | 429 |
| 40 | Peginterferon alpha-2a (40 kDa): an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B | Journal of Viral Hepatitis | 2003 | 427 |
| 41 | Morphology of sporadic colorectal cancer with DNA replication errors | Gut | 1998 | 422 |
| 42 | Suicidal behaviour: an epidemiological and genetic study | Psychological Medicine | 1998 | 419 |
| 43 | Co-activation of the abdominal and pelvic floor muscles during voluntary exercises | Neurourology and Urodynamics | 2001 | 413 |
| 44 | Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function | Nature Communications | 2016 | 412 |
| 45 | Common infections in diabetes: pathogenesis, management and relationship to glycaemic control | Diabetes/Metabolism Research and Reviews | 2007 | 411 |
| 46 | Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors | Nature Genetics | 2019 | 402 |
| 47 | Direct evidence for catalase and peroxidase activities of ferritin–platinum nanoparticles | Biomaterials | 2011 | 397 |
| 48 | The 2019 World Health Organization classification of tumours of the breast | Histopathology | 2020 | 395 |
| 49 | Impact of Mannose-Binding Lectin on Susceptibility to Infectious Diseases | Clinical Infectious Diseases | 2003 | 392 |
| 50 | Identification of seven new prostate cancer susceptibility loci through a genome-wide association study | Nature Genetics | 2009 | 389 |
