| # | Title | Journal | Year | Citations |
|---|
| 1 | Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia | Blood | 1999 | 2,376 |
| 2 | Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2015 | 1,261 |
| 3 | Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders | Nature Genetics | 2010 | 1,034 |
| 4 | Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA) | Annals of Oncology | 2013 | 895 |
| 5 | Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia | Blood | 1999 | 841 |
| 6 | Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk | New England Journal of Medicine | 2015 | 672 |
| 7 | Randomized Trial of Complete Versus Lesion-Only Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI and Multivessel Disease | Journal of the American College of Cardiology | 2015 | 662 |
| 8 | Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial | Lancet, The | 2007 | 660 |
| 9 | Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial | BMJ: British Medical Journal | 2004 | 647 |
| 10 | Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation | Journal of Experimental Medicine | 2011 | 565 |
| 11 | CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease | Blood | 2002 | 555 |
| 12 | Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia | Cancer Cell | 2011 | 545 |
| 13 | Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial | Lancet, The | 2018 | 526 |
| 14 | ZAP-70 expression and prognosis in chronic lymphocytic leukaemia | Lancet, The | 2004 | 504 |
| 15 | Improved Glycemic Control in Poorly Controlled Patients with Type 1 Diabetes Using Real-Time Continuous Glucose Monitoring | Diabetes Care | 2006 | 487 |
| 16 | Guidelines for the diagnosis and management of aplastic anaemia | British Journal of Haematology | 2009 | 487 |
| 17 | Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors | Blood | 2002 | 462 |
| 18 | Papillary cannulation and sphincterotomy techniques at ERCP: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2016 | 417 |
| 19 | Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzumab for treatment-naive chronic lymphocytic leukaemia (ELEVATE-TN): a randomised, controlled, phase 3 trial | Lancet, The | 2020 | 393 |
| 20 | Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline | Endoscopy | 2019 | 390 |
| 21 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial | Lancet Oncology, The | 2014 | 371 |
| 22 | Uninterrupted rivaroxaban vs. uninterrupted vitamin K antagonists for catheter ablation in non-valvular atrial fibrillation | European Heart Journal | 2015 | 370 |
| 23 | JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms | Nature Genetics | 2009 | 365 |
| 24 | Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies | Blood | 2012 | 350 |
| 25 | Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms | Blood | 2009 | 349 |
| 26 | Prevalence and Relative Risk of Other Autoimmune Diseases in Subjects with Autoimmune Thyroid Disease | American Journal of Medicine | 2010 | 331 |
| 27 | Adjuvant Therapy With Fluorouracil and Oxaliplatin in Stage II and Elderly Patients (between ages 70 and 75 years) With Colon Cancer: Subgroup Analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer Trial | Journal of Clinical Oncology | 2012 | 330 |
| 28 | Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis | British Journal of Haematology | 2005 | 314 |
| 29 | Updated guideline on the management of common bile duct stones (CBDS) | Gut | 2017 | 302 |
| 30 | Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial | Lancet Oncology, The | 2014 | 296 |
| 31 | Therapeutic Angiogenesis With Intramuscular NV1FGF Improves Amputation-free Survival in Patients With Critical Limb Ischemia | Molecular Therapy | 2008 | 294 |
| 32 | A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease | Blood | 2003 | 275 |
| 33 | The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo | Blood | 2010 | 271 |
| 34 | Guideline for the diagnosis and management of the rare coagulation disorders | British Journal of Haematology | 2014 | 266 |
| 35 | Recurrent mutations refine prognosis in chronic lymphocytic leukemia | Leukemia | 2015 | 253 |
| 36 | Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells | Leukemia | 2010 | 250 |
| 37 | Outcomes of COVID-19 in patients with CLL: a multicenter international experience | Blood | 2020 | 248 |
| 38 | Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria | Leukemia | 2008 | 244 |
| 39 | BTS guidelines for the insertion of a chest drain | Thorax | 2003 | 241 |
| 40 | Assessment of Molecular Relapse Detection in Early-Stage Breast Cancer | JAMA Oncology | 2019 | 237 |
| 41 | Mutational Status of the TP53 Gene As a Predictor of Response and Survival in Patients With Chronic Lymphocytic Leukemia: Results From the LRF CLL4 Trial | Journal of Clinical Oncology | 2011 | 235 |
| 42 | Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia | Leukemia | 2010 | 231 |
| 43 | Adaptor protein 3–dependent microtubule-mediated movement of lytic granules to the immunological synapse | Nature Immunology | 2003 | 227 |
| 44 | Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy | Blood | 2011 | 226 |
| 45 | Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk | Nature Genetics | 2010 | 223 |
| 46 | Radiofrequency Ablation and Endoscopic Mucosal Resection for Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma: Outcomes of the UK National Halo RFA Registry | Gastroenterology | 2013 | 223 |
| 47 | Skin-Related Complications of Insulin Therapy | American Journal of Clinical Dermatology | 2003 | 216 |
| 48 | Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS) | Breast Cancer Research | 2010 | 216 |
| 49 | An Investigation into the Response of Palatally Displaced Canines to the Removal of Deciduous Canines and an Assessment of Factors Contributing to Favourable Eruption | British Journal of Orthodontics | 1993 | 214 |
| 50 | RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up | Leukemia | 1998 | 212 |
