| # | Title | Journal | Year | Citations |
|---|
| 1 | Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network | Pediatrics | 2010 | 2,252 |
| 2 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
| 3 | Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature | Natural Product Reports | 2013 | 1,692 |
| 4 | Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy | Nature | 2016 | 1,371 |
| 5 | Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial | Lancet, The | 2017 | 1,250 |
| 6 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 7 | A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation | Cell | 2008 | 951 |
| 8 | Barrier Function of the Skin: “La Raison d'Être” of the Epidermis | Journal of Investigative Dermatology | 2003 | 917 |
| 9 | The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function | Cell Metabolism | 2014 | 876 |
| 10 | Antipsychotic Dose Equivalents and Dose-Years: A Standardized Method for Comparing Exposure to Different Drugs | Biological Psychiatry | 2010 | 852 |
| 11 | ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia | Journal of Virology | 2005 | 782 |
| 12 | Common genetic variants influence human subcortical brain structures | Nature | 2015 | 772 |
| 13 | Post-Stroke Depression: A Review | American Journal of Psychiatry | 2016 | 739 |
| 14 | The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited | Progress in Retinal and Eye Research | 2010 | 696 |
| 15 | Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung | Nature | 2012 | 691 |
| 16 | Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification | Molecular Cell | 2008 | 660 |
| 17 | Device Selection and Outcomes of Aerosol Therapy: Evidence-Based Guidelines | Chest | 2005 | 659 |
| 18 | Regulation of pyruvate metabolism and human disease | Cellular and Molecular Life Sciences | 2014 | 587 |
| 19 | Staphylococcus aureusBiofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo | Journal of Immunology | 2011 | 563 |
| 20 | Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1 | Immunity | 2010 | 555 |
| 21 | The Role of the Cerebellum in Schizophrenia | Biological Psychiatry | 2008 | 552 |
| 22 | The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae | Genetics | 2012 | 552 |
| 23 | A genome-wide scan for common alleles affecting risk for autism | Human Molecular Genetics | 2010 | 538 |
| 24 | Acid-sensing ion channels: advances, questions and therapeutic opportunities | Trends in Neurosciences | 2006 | 505 |
| 25 | C3 glomerulopathy: consensus report | Kidney International | 2013 | 505 |
| 26 | PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53 | Science | 2005 | 500 |
| 27 | Nicotinamide riboside is uniquely and orally bioavailable in mice and humans | Nature Communications | 2016 | 498 |
| 28 | GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration | Nature Neuroscience | 2015 | 496 |
| 29 | Using Internet Searches for Influenza Surveillance | Clinical Infectious Diseases | 2008 | 468 |
| 30 | NetPath: a public resource of curated signal transduction pathways | Genome Biology | 2010 | 456 |
| 31 | T cell-mediated immune response to respiratory coronaviruses | Immunologic Research | 2014 | 448 |
| 32 | Deep learning for neuroimaging: a validation study | Frontiers in Neuroscience | 2014 | 441 |
| 33 | Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation | Nature Medicine | 2018 | 433 |
| 34 | Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells | Journal of Immunology | 2014 | 425 |
| 35 | Vascular Protection | Arteriosclerosis, Thrombosis, and Vascular Biology | 2004 | 422 |
| 36 | Staphylococcal and Streptococcal Superantigen Exotoxins | Clinical Microbiology Reviews | 2013 | 408 |
| 37 | Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System | Circulation Research | 2004 | 407 |
| 38 | Poststroke depression: prevalence, diagnosis, treatment, and disease progression | Biological Psychiatry | 2003 | 402 |
| 39 | Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps | Journal of Innate Immunity | 2010 | 402 |
| 40 | The Mechanosensitivity of Mouse Colon Afferent Fibers and Their Sensitization by Inflammatory Mediators Require Transient Receptor Potential Vanilloid 1 and Acid-Sensing Ion Channel 3 | Journal of Neuroscience | 2005 | 392 |
| 41 | Phosphorylation of Tau by Fyn: Implications for Alzheimer's Disease | Journal of Neuroscience | 2004 | 386 |
| 42 | Dystrophin-Glycoprotein Complex: Post-translational Processing and Dystroglycan Function | Journal of Biological Chemistry | 2003 | 380 |
| 43 | Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis | Cell | 2012 | 377 |
| 44 | Antifungal Susceptibilities of Candida Species Causing Vulvovaginitis and Epidemiology of Recurrent Cases | Journal of Clinical Microbiology | 2005 | 362 |
| 45 | Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of an International Phase III Trial | Stroke | 2008 | 362 |
| 46 | Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2007 | 357 |
| 47 | Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease) | Journal of the American Society of Nephrology: JASN | 2005 | 354 |
| 48 | Segregation of receptor and ligand regulates activation of epithelial growth factor receptor | Nature | 2003 | 348 |
| 49 | Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 348 |
| 50 | Drug resistance and tolerance in fungi | Nature Reviews Microbiology | 2020 | 342 |
