| # | Title | Journal | Year | Citations |
|---|
| 1 | NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal -defensin expression | Gut | 2004 | 715 |
| 2 | A Chromosome 8 Gene-Cluster Polymorphism with Low Human Beta-Defensin 2 Gene Copy Number Predisposes to Crohn Disease of the Colon | American Journal of Human Genetics | 2006 | 487 |
| 3 | Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs | Frontiers in Immunology | 2019 | 473 |
| 4 | NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells by Escherichia coli Nissle 1917: a Novel Effect of a Probiotic Bacterium | Infection and Immunity | 2004 | 437 |
| 5 | Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1 | Nature | 2011 | 428 |
| 6 | Cost of falls in old age: a systematic review | Osteoporosis International | 2010 | 413 |
| 7 | Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation | Blood | 2012 | 381 |
| 8 | The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells | Pharmacogenetics and Genomics | 2001 | 359 |
| 9 | Evaluation of Accelerometer-Based Fall Detection Algorithms on Real-World Falls | PLoS ONE | 2012 | 359 |
| 10 | Transbronchial Cryobiopsy: A New Tool for Lung Biopsies | Respiration | 2009 | 350 |
| 11 | Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2 | Clinical and Experimental Immunology | 2008 | 313 |
| 12 | The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology | European Heart Journal | 2014 | 301 |
| 13 | Telomere length in different tissues of elderly patients | Mechanisms of Ageing and Development | 2000 | 292 |
| 14 | NOD2/CARD15 Mediates Induction of the Antimicrobial Peptide Human Beta-defensin-2 | Journal of Biological Chemistry | 2006 | 288 |
| 15 | Induction of Human β-Defensin 2 by the Probiotic Escherichia coli Nissle 1917 Is Mediated through Flagellin | Infection and Immunity | 2007 | 288 |
| 16 | The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-4 | Journal of Immunology | 2007 | 287 |
| 17 | PET-guided treatment in patients with advanced-stage Hodgkin's lymphoma (HD18): final results of an open-label, international, randomised phase 3 trial by the German Hodgkin Study Group | Lancet, The | 2017 | 274 |
| 18 | Extraintestinal manifestations and complications in inflammatory bowel diseases | World Journal of Gastroenterology | 2006 | 271 |
| 19 | World guidelines for falls prevention and management for older adults: a global initiative | Age and Ageing | 2022 | 263 |
| 20 | Inducible and Constitutive β-Defensins Are Differentially Expressed in Crohn's Disease and Ulcerative Colitis | Inflammatory Bowel Diseases | 2003 | 260 |
| 21 | Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma | Clinical Pharmacology and Therapeutics | 2011 | 241 |
| 22 | Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis | Differentiation | 2009 | 229 |
| 23 | Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells | Cell Death and Disease | 2019 | 228 |
| 24 | Mindfulness-based interventions for women with breast cancer: an updated systematic review and meta-analysis | Acta Oncológica | 2017 | 194 |
| 25 | Naltrexone Does Not Relieve Uremic Pruritus | Journal of the American Society of Nephrology: JASN | 2000 | 192 |
| 26 | Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: Differential elevation of cyclooxygenase 2 in inflammatory joint diseases | Arthritis and Rheumatism | 1998 | 191 |
| 27 | Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 183 |
| 28 | Trend of hip fracture incidence in Germany 1995–2004: a population-based study | Osteoporosis International | 2008 | 182 |
| 29 | Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics | Neurobiology of Disease | 2009 | 177 |
| 30 | Distance to achieve steady state walking speed in frail elderly persons | Gait and Posture | 2008 | 166 |
| 31 | Epidemiology of Falls in Residential Aged Care: Analysis of More Than 70,000 Falls From Residents of Bavarian Nursing Homes | Journal of the American Medical Directors Association | 2012 | 165 |
| 32 | Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense | Hepatology | 2012 | 164 |
| 33 | Radical video-assisted mediastinoscopic lymphadenectomy (VAMLA) – technique and first results | European Journal of Cardio-thoracic Surgery | 2002 | 155 |
| 34 | Modified atherogenic lipoproteins induce expression of pentraxin-3 by human vascular smooth muscle cells | Atherosclerosis | 2004 | 152 |
| 35 | Reporting of complex interventions in clinical trials: development of a taxonomy to classify and describe fall-prevention interventions | Trials | 2011 | 151 |
| 36 | Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases | European Journal of Gastroenterology and Hepatology | 2006 | 149 |
| 37 | Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans | Mucosal Immunology | 2009 | 148 |
| 38 | Response of Refractory Colitis to Intravenous or Oral Tacrolimus (FK506) | Inflammatory Bowel Diseases | 2002 | 147 |
| 39 | Elevated Human β-Defensin-2 Levels Indicate an Activation of the Innate Immune System in Patients With Irritable Bowel Syndrome | American Journal of Gastroenterology | 2009 | 146 |
| 40 | Thiopurine Treatment in Inflammatory Bowel Disease | Clinical Pharmacokinetics | 2007 | 145 |
| 41 | Follicular lymphoma grade 3B is a distinct neoplasm according to cytogenetic and immunohistochemical profiles | Haematologica | 2011 | 142 |
| 42 | Short-term versus long-term antiarrhythmic drug treatment after cardioversion of atrial fibrillation (Flec-SL): a prospective, randomised, open-label, blinded endpoint assessment trial | Lancet, The | 2012 | 141 |
| 43 | Reduced mucosal antimicrobial activity in Crohn's disease of the colon | Gut | 2007 | 138 |
| 44 | Impact of clinical factors and surgical techniques on early outcome of patients treated with frozen elephant trunk technique by using EVITA open stent-graft: results of a multicentre study | European Journal of Cardio-thoracic Surgery | 2016 | 132 |
| 45 | Hip Fractures in Institutionalized Elderly People: Incidence Rates and Excess Mortality | Journal of Bone and Mineral Research | 2008 | 131 |
| 46 | TGF-Beta Signaling in Breast Cancer | Annals of the New York Academy of Sciences | 2006 | 128 |
| 47 | Comparison of acceleration signals of simulated and real-world backward falls | Medical Engineering and Physics | 2011 | 127 |
| 48 | Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers | Cancer Discovery | 2021 | 125 |
| 49 | Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease | PLoS ONE | 2009 | 125 |
| 50 | Reoperations on the pulmonary autograft and pulmonary homograft after the Ross procedure: An update on the German Dutch Ross Registry | Journal of Thoracic and Cardiovascular Surgery | 2012 | 122 |
