| # | Title | Journal | Year | Citations |
|---|
| 1 | The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 7,498 |
| 2 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Critical Care Medicine | 2003 | 5,266 |
| 3 | Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis | Nature Genetics | 2006 | 2,584 |
| 4 | Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis | Science | 2009 | 2,302 |
| 5 | Guidelines for the Prevention of Intravascular Catheter-related Infections | Clinical Infectious Diseases | 2011 | 2,242 |
| 6 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 | Intensive Care Medicine | 2008 | 2,078 |
| 7 | Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial | Lancet, The | 2005 | 2,070 |
| 8 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Intensive Care Medicine | 2003 | 1,965 |
| 9 | Weaning from mechanical ventilation | European Respiratory Journal | 2007 | 1,962 |
| 10 | The Children's Sleep Habits Questionnaire (CSHQ): Psychometric Properties of A Survey Instrument for School-Aged Children | Sleep | 2000 | 1,688 |
| 11 | A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies | American Journal of Clinical Pathology | 1981 | 1,649 |
| 12 | Developing a New Definition and Assessing New Clinical Criteria for Septic Shock | JAMA - Journal of the American Medical Association | 2016 | 1,622 |
| 13 | Practice Parameters for the Indications for Polysomnography and Related Procedures: An Update for 2005 | Sleep | 2005 | 1,590 |
| 14 | The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis | Neuron | 2003 | 1,465 |
| 15 | Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes? | Journal of Alzheimer's Disease | 2005 | 1,445 |
| 16 | Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure | New England Journal of Medicine | 2008 | 1,421 |
| 17 | Guidelines for the Management of Intravascular Catheter-Related Infections | Clinical Infectious Diseases | 2001 | 1,354 |
| 18 | The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America | Clinical Infectious Diseases | 2011 | 1,230 |
| 19 | Sepsis and septic shock | Lancet, The | 2018 | 1,205 |
| 20 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis | Intensive Care Medicine | 2010 | 1,180 |
| 21 | The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis* | Critical Care Medicine | 2010 | 1,094 |
| 22 | Guidelines for the Prevention of Intravascular Catheter–Related Infections | Infection Control and Hospital Epidemiology | 2002 | 1,024 |
| 23 | Practice Parameters for the Use of Actigraphy in the Assessment of Sleep and Sleep Disorders: An Update for 2007 | Sleep | 2007 | 1,004 |
| 24 | Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke | Annals of Neurology | 1992 | 970 |
| 25 | The Global Burden of Asthma | Chest | 2006 | 964 |
| 26 | Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris | Nature Genetics | 2006 | 916 |
| 27 | Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice | Journal of Leukocyte Biology | 2008 | 913 |
| 28 | Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease | Annals of Internal Medicine | 2000 | 905 |
| 29 | Image-guided Tumor Ablation: Standardization of Terminology and Reporting Criteria—A 10-Year Update | Radiology | 2014 | 870 |
| 30 | Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed | Journal of Diabetes Science and Technology | 2008 | 853 |
| 31 | Microwave Ablation: Principles and Applications | Radiographics | 2005 | 814 |
| 32 | Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III | Nature Genetics | 1997 | 812 |
| 33 | Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study | British Journal of Cancer | 2001 | 790 |
| 34 | The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation | Transplantation | 2018 | 784 |
| 35 | Patients’ use of the internet for medical information | Journal of General Internal Medicine | 2002 | 783 |
| 36 | Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis | Molecular Endocrinology | 2002 | 776 |
| 37 | Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives | European Respiratory Journal | 2019 | 776 |
| 38 | Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections | Nature Genetics | 2007 | 767 |
| 39 | Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis | JAMA - Journal of the American Medical Association | 2019 | 753 |
| 40 | Severity classification on the Hamilton depression rating scale | Journal of Affective Disorders | 2013 | 745 |
| 41 | Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension | Journal of the American College of Cardiology | 2002 | 729 |
| 42 | Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study | Journal of the American College of Cardiology | 2006 | 727 |
| 43 | A Comparison of Directional Atherectomy with Coronary Angioplasty in Patients with Coronary Artery Disease | New England Journal of Medicine | 1993 | 680 |
| 44 | Practice Parameters for the Use of Continuous and Bilevel Positive Airway Pressure Devices to Treat Adult Patients With Sleep-Related Breathing Disorders | Sleep | 2006 | 680 |
| 45 | Coronary Microvascular Reactivity to Adenosine Predicts Adverse Outcome in Women Evaluated for Suspected Ischemia | Journal of the American College of Cardiology | 2010 | 660 |
| 46 | Multiple Recurrences of Major Depressive Disorder | American Journal of Psychiatry | 2000 | 639 |
| 47 | Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine | Journal of Alzheimer's Disease | 2005 | 631 |
| 48 | The Children's Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children | Sleep | 2000 | 629 |
| 49 | Practice Parameters for the Psychological and Behavioral Treatment of Insomnia: An Update. An American Academy of Sleep Medicine Report | Sleep | 2006 | 628 |
| 50 | Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study | Journal of the American College of Cardiology | 2006 | 620 |
