| # | Title | Journal | Year | Citations |
|---|
| 1 | Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds | Journal of Virological Methods | 1988 | 1,644 |
| 2 | Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity | Science | 2016 | 1,398 |
| 3 | An index of substitution saturation and its application | Molecular Phylogenetics and Evolution | 2003 | 1,315 |
| 4 | Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation | Journal of Biological Chemistry | 2003 | 1,286 |
| 5 | The neuroactive potential of the human gut microbiota in quality of life and depression | Nature Microbiology | 2019 | 1,206 |
| 6 | Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways | Nature Neuroscience | 2013 | 1,121 |
| 7 | Approved Antiviral Drugs over the Past 50 Years | Clinical Microbiology Reviews | 2016 | 1,049 |
| 8 | Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 | Nature Medicine | 2002 | 1,008 |
| 9 | CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity | Nature Neuroscience | 2001 | 996 |
| 10 | Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues | Journal of Virology | 2004 | 900 |
| 11 | Antiviral drugs in current clinical use | Journal of Clinical Virology | 2004 | 860 |
| 12 | Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update | PLoS ONE | 2009 | 823 |
| 13 | Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9) | Critical Reviews in Biochemistry and Molecular Biology | 2002 | 805 |
| 14 | Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives | Nature | 1990 | 794 |
| 15 | Full Genome-Based Classification of Rotaviruses Reveals a Common Origin between Human Wa-Like and Porcine Rotavirus Strains and Human DS-1-Like and Bovine Rotavirus Strains | Journal of Virology | 2008 | 791 |
| 16 | N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 | Cell | 2021 | 784 |
| 17 | A novel selective broad-spectrum anti-DNA virus agent | Nature | 1986 | 782 |
| 18 | AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor | Nature Medicine | 1998 | 760 |
| 19 | Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for Intervention with HIV Infections | Journal of Medicinal Chemistry | 1995 | 711 |
| 20 | Response of Serum Interleukin-6 in Patients Undergoing Elective Surgery of Varying Severity | Clinical Science | 1990 | 703 |
| 21 | Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases | Nature Reviews Drug Discovery | 2007 | 680 |
| 22 | The CC chemokine CCL20 and its receptor CCR6 | Cytokine and Growth Factor Reviews | 2003 | 660 |
| 23 | Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus | Journal of Infectious Diseases | 1980 | 643 |
| 24 | Angiogenesis: regulators and clinical applications | Biochemical Pharmacology | 2001 | 643 |
| 25 | Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments | Archives of Virology | 2008 | 642 |
| 26 | Human T-lymphotropic virus 1: recent knowledge about an ancient infection | Lancet Infectious Diseases, The | 2007 | 622 |
| 27 | Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade | Critical Reviews in Biochemistry and Molecular Biology | 2013 | 622 |
| 28 | Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact | Blood | 2000 | 615 |
| 29 | Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture | Antimicrobial Agents and Chemotherapy | 2014 | 611 |
| 30 | HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells | Journal of Biological Chemistry | 2003 | 608 |
| 31 | Acyclic nucleoside phosphonates: a key class of antiviral drugs | Nature Reviews Drug Discovery | 2005 | 587 |
| 32 | Antiviral agents active against influenza A viruses | Nature Reviews Drug Discovery | 2006 | 586 |
| 33 | Macrophage inflammatory protein-1 | Cytokine and Growth Factor Reviews | 2002 | 577 |
| 34 | Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy | British Journal of Pharmacology | 2006 | 572 |
| 35 | Strategies in the design of antiviral drugs | Nature Reviews Drug Discovery | 2002 | 566 |
| 36 | The role of CXC chemokines and their receptors in cancer | Cancer Letters | 2008 | 565 |
| 37 | Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4 | Journal of Experimental Medicine | 1997 | 559 |
| 38 | In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine | Biochemical and Biophysical Research Communications | 2004 | 530 |
| 39 | Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines | Antiviral Research | 1987 | 518 |
| 40 | The early spread and epidemic ignition of HIV-1 in human populations | Science | 2014 | 515 |
| 41 | Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV | International Journal of Antimicrobial Agents | 2009 | 510 |
| 42 | Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms | Science | 2020 | 504 |
| 43 | Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus | Antimicrobial Agents and Chemotherapy | 1988 | 497 |
| 44 | Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide | European Journal of Pharmaceutical Sciences | 1999 | 479 |
| 45 | Zoonotic aspects of rotaviruses | Veterinary Microbiology | 2010 | 479 |
| 46 | Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event | Journal of Virology | 2005 | 477 |
| 47 | Sulfated Polysaccharides Extracted from Sea Algae as Potential Antiviral Drugs | General Pharmacology | 1997 | 469 |
| 48 | Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy | Clinical Microbiology Reviews | 2005 | 466 |
| 49 | Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 464 |
| 50 | Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio | EMBO Journal | 2010 | 455 |
