| # | Title | Journal | Year | Citations |
|---|
| 1 | Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man | Diabetologia | 1985 | 27,582 |
| 2 | Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study | BMJ: British Medical Journal | 2000 | 7,060 |
| 3 | Blood pressure, stroke, and coronary heart disease *1Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias | Lancet, The | 1990 | 4,062 |
| 4 | Blood pressure, stroke, and coronary heart disease | Lancet, The | 1990 | 3,695 |
| 5 | Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial | Lancet, The | 2003 | 3,420 |
| 6 | International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial | Lancet, The | 2002 | 3,333 |
| 7 | Mortality in relation to smoking: 40 years' observations on male British doctors | BMJ: British Medical Journal | 1994 | 2,841 |
| 8 | Breast cancer and hormone-replacement therapy in the Million Women Study | Lancet, The | 2003 | 2,762 |
| 9 | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology | Canadian Journal of Gastroenterology & Hepatology | 2005 | 2,711 |
| 10 | Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial | Lancet, The | 2005 | 2,662 |
| 11 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 12 | Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes MellitusProgressive Requirement for Multiple Therapies (UKPDS 49) | JAMA - Journal of the American Medical Association | 1999 | 2,099 |
| 13 | External validity of randomised controlled trials: “To whom do the results of this trial apply?” | Lancet, The | 2005 | 1,959 |
| 14 | SEMANTIC DEMENTIA | Brain | 1992 | 1,786 |
| 15 | Publication and related bias in meta-analysis | Journal of Clinical Epidemiology | 2000 | 1,768 |
| 16 | Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study | BMJ: British Medical Journal | 2000 | 1,737 |
| 17 | Can dietary beta-carotene materially reduce human cancer rates? | Nature | 1981 | 1,664 |
| 18 | Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries | Lancet, The | 2004 | 1,539 |
| 19 | Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women: Reanalysis of Nine Prospective Studies | Journal of the National Cancer Institute | 2002 | 1,510 |
| 20 | Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis | Lancet, The | 2003 | 1,461 |
| 21 | Subarachnoid haemorrhage | Lancet, The | 2007 | 1,453 |
| 22 | Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses | BMJ: British Medical Journal | 2000 | 1,384 |
| 23 | Questionnaire on the perceptions of patients about total knee replacement | Journal of Bone and Joint Surgery: British Volume | 1998 | 1,346 |
| 24 | Reduction in Fatal Pulmonary Embolism and Venous Thrombosis by Perioperative Administration of Subcutaneous Heparin | New England Journal of Medicine | 1988 | 1,334 |
| 25 | Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery | Lancet, The | 2004 | 1,334 |
| 26 | Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies | BMJ: British Medical Journal | 2005 | 1,284 |
| 27 | Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies | Lancet, The | 1996 | 1,266 |
| 28 | Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) | Nature | 1996 | 1,240 |
| 29 | Mortality from tobacco in developed countries: indirect estimation from national vital statistics | Lancet, The | 1992 | 1,175 |
| 30 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack | Lancet, The | 2007 | 1,160 |
| 31 | Cholinesterase inhibitors for Alzheimer's disease | Lancet, The | 2006 | 1,156 |
| 32 | Breast cancer and hormone-replacement therapy: the Million Women Study | Lancet, The | 2003 | 1,121 |
| 33 | Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies | BMJ: British Medical Journal | 2000 | 1,120 |
| 34 | Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS | Nature Medicine | 1997 | 1,096 |
| 35 | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility | Nature Genetics | 2007 | 1,063 |
| 36 | Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison | Lancet, The | 2007 | 1,058 |
| 37 | The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease | Quality of Life Research | 1995 | 1,004 |
| 38 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study | Lancet, The | 2003 | 988 |
| 39 | Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion | Clinical Chemistry | 2004 | 913 |
| 40 | Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies, including 58 515 women with breast cancer and 95 067 women without the disease | British Journal of Cancer | 2002 | 885 |
| 41 | Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study) | Lancet, The | 2005 | 848 |
| 42 | Subgroup analysis in randomised controlled trials: importance, indications, and interpretation | Lancet, The | 2005 | 776 |
| 43 | Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies | Lancet, The | 2007 | 741 |
| 44 | AN EXPERIMENT TO DETERMINE THE ACTIVE THERAPEUTIC MOIETY OF SULPHASALAZINE | Lancet, The | 1977 | 737 |
| 45 | A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project--1981-86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage. | Journal of Neurology, Neurosurgery and Psychiatry | 1990 | 736 |
| 46 | The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56) | Clinical Science | 2001 | 734 |
| 47 | The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials | BJOG: an International Journal of Obstetrics and Gynaecology | 1990 | 730 |
| 48 | What counts as evidence in evidence-based practice? | Journal of Advanced Nursing | 2004 | 718 |
| 49 | Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years | Journal of Advanced Nursing | 1998 | 715 |
| 50 | Underestimation of Risk Associations Due to Regression Dilution in Long-term Follow-up of Prospective Studies | American Journal of Epidemiology | 1999 | 706 |
