| # | Title | Journal | Year | Citations |
|---|
| 1 | A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease | New England Journal of Medicine | 1994 | 4,014 |
| 2 | Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure | New England Journal of Medicine | 2010 | 1,585 |
| 3 | A BLINDED, RANDOMIZED CLINICAL TRIAL OF MYCOPHENOLATE MOFETIL FOR THE PREVENTION OF ACUTE REJECTION IN CADAVERIC RENAL TRANSPLANTATION1 | Transplantation | 1996 | 933 |
| 4 | Prevalence and severity of cognitive impairment with and without dementia in an elderly population | Lancet, The | 1997 | 893 |
| 5 | Cancer Survivors’ Adherence to Lifestyle Behavior Recommendations and Associations With Health-Related Quality of Life: Results From the American Cancer Society's SCS-II | Journal of Clinical Oncology | 2008 | 858 |
| 6 | Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer | New England Journal of Medicine | 2021 | 835 |
| 7 | External validation and comparison with other models of the International Metastatic Renal-Cell Carcinoma Database Consortium prognostic model: a population-based study | Lancet Oncology, The | 2013 | 808 |
| 8 | 2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure | Canadian Journal of Cardiology | 2017 | 503 |
| 9 | Propofol vs Midazolam for ICU Sedation | Chest | 2001 | 402 |
| 10 | Oral Anticoagulant and Antiplatelet Therapy and Peripheral Arterial Disease | New England Journal of Medicine | 2007 | 383 |
| 11 | 2014 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation | Canadian Journal of Cardiology | 2014 | 382 |
| 12 | Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium | European Urology | 2014 | 382 |
| 13 | Effect of Pravastatin on Cardiovascular Events in Older Patients with Myocardial Infarction and Cholesterol Levels in the Average Range: Results of the Cholesterol and Recurrent Events (CARE) Trial | Annals of Internal Medicine | 1998 | 381 |
| 14 | Surgical Versus Nonsurgical Treatment of Acute Achilles Tendon Rupture | Journal of Bone and Joint Surgery - Series A | 2012 | 379 |
| 15 | Association of mutations in theNALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis | Arthritis and Rheumatism | 2002 | 350 |
| 16 | Fatigue after stroke | Archives of Physical Medicine and Rehabilitation | 1999 | 340 |
| 17 | Comparison of Immediate vs Deferred Cytoreductive Nephrectomy in Patients With Synchronous Metastatic Renal Cell Carcinoma Receiving Sunitinib | JAMA Oncology | 2019 | 329 |
| 18 | Natural history and patterns of current practice in heart failure | Journal of the American College of Cardiology | 1993 | 324 |
| 19 | Sirolimus-tacrolimus combination immunosuppression | Lancet, The | 2000 | 324 |
| 20 | Immediate versus deferred chemotherapy after radical cystectomy in patients with pT3–pT4 or N+ M0 urothelial carcinoma of the bladder (EORTC 30994): an intergroup, open-label, randomised phase 3 trial | Lancet Oncology, The | 2015 | 323 |
| 21 | Improvements in Symptom-Limited Exercise Performance Over 8 h With Once-Daily Tiotropium in Patients With COPD | Chest | 2005 | 291 |
| 22 | Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018 | International Journal of Stroke | 2018 | 272 |
| 23 | Intermediate-Term Results of Total Ankle Replacement and Ankle Arthrodesis | Journal of Bone and Joint Surgery - Series A | 2014 | 263 |
| 24 | 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias | Europace | 2019 | 245 |
| 25 | Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF121 (AdVEGF121) versus maximum medical treatment | Gene Therapy | 2006 | 244 |
| 26 | 2016 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation | Canadian Journal of Cardiology | 2016 | 243 |
| 27 | Conceptualisation and Measurement of Frailty in Elderly People | Drugs and Aging | 2000 | 233 |
| 28 | Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial | Journal of Neurology, Neurosurgery and Psychiatry | 2001 | 230 |
| 29 | A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus | Arthritis and Rheumatism | 1999 | 217 |
| 30 | Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma | Blood | 2018 | 216 |
| 31 | The influence of foot position on standing balance | Journal of Biomechanics | 1987 | 214 |
| 32 | Screening for atrial fibrillation: a European Heart Rhythm Association (EHRA) consensus document endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLAECE) | Europace | 2017 | 208 |
| 33 | Cardiac surgery in octogenarians: can elderly patients benefit? quality of life after cardiac surgery | Annals of Thoracic Surgery | 1999 | 207 |
| 34 | Noninvasive Positive Pressure Ventilation | Chest | 1999 | 203 |
| 35 | 2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation | Canadian Journal of Cardiology | 2018 | 195 |
| 36 | The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy | Canadian Journal of Cardiology | 2010 | 191 |
| 37 | Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy | Canadian Journal of Cardiology | 2016 | 190 |
| 38 | Metastatic non–clear cell renal cell carcinoma treated with targeted therapy agents: Characterization of survival outcome and application of the International mRCC Database Consortium criteria | Cancer | 2013 | 189 |
| 39 | What do we know about frailty in the acute care setting? A scoping review | BMC Geriatrics | 2018 | 188 |
| 40 | Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of POLLUX | Haematologica | 2018 | 187 |
| 41 | Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis* | Critical Care Medicine | 2003 | 185 |
| 42 | Neosis: A Novel Type of Cell Division in Cancer | Cancer Biology and Therapy | 2004 | 184 |
| 43 | 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias | Heart Rhythm | 2020 | 184 |
| 44 | First-Line Treatment of Patients With Indolent Non-Hodgkin Lymphoma or Mantle-Cell Lymphoma With Bendamustine Plus Rituximab Versus R-CHOP or R-CVP: Results of the BRIGHT 5-Year Follow-Up Study | Journal of Clinical Oncology | 2019 | 183 |
| 45 | Primary neuroendocrine (Merkel cell) carcinoma of the skin: Morphologic diversity and implications thereof | Human Pathology | 2001 | 180 |
| 46 | Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study | Thorax | 2015 | 178 |
| 47 | In vivo reflectance confocal microscopy imaging of melanocytic skin lesions: Consensus terminology glossary and illustrative images | Journal of the American Academy of Dermatology | 2007 | 176 |
| 48 | Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations | Journal of Clinical Oncology | 2016 | 174 |
| 49 | CCS/CHFS Heart Failure Guidelines Update: Defining a New Pharmacologic Standard of Care for Heart Failure With Reduced Ejection Fraction | Canadian Journal of Cardiology | 2021 | 170 |
| 50 | Nucleic Acid Testing (NAT) of Organ Donors: Is the ‘Best’ Test the Right Test? A Consensus Conference Report | American Journal of Transplantation | 2010 | 164 |
