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VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model | Nature | 2004 | 515 |
The BioPAX community standard for pathway data sharing | Nature Biotechnology | 2010 | 499 |
Minimum information requested in the annotation of biochemical models (MIRIAM) | Nature Biotechnology | 2005 | 445 |
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model | Nature Medicine | 2005 | 412 |
Dynamical Monte Carlo modelling of organic solar cells: the dependence of internal quantum efficiency on morphology | Nano Letters | 2005 | 339 |
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Research | 2011 | 332 |
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery | Human Molecular Genetics | 2001 | 331 |
Efficient production of germline transgenic chickens using lentiviral vectors | EMBO Reports | 2004 | 296 |
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 278 |
Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis | Rheumatology | 2006 | 265 |
Protein detection by nanopores equipped with aptamers | Journal of the American Chemical Society | 2012 | 234 |
Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription | EMBO Journal | 1999 | 202 |
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection | Nature Biotechnology | 2019 | 188 |
Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data | Lancet Neurology, The | 2018 | 179 |
Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy | Gene Therapy | 2008 | 168 |
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates | Journal of Biological Chemistry | 2007 | 164 |
Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications | Human Gene Therapy | 2006 | 161 |
Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy | Journal of Clinical Investigation | 2004 | 160 |
Continuous high-titer HIV-1 vector production | Nature Biotechnology | 2003 | 150 |
ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature | Cancer Research | 2002 | 148 |
Formation of droplet networks that function in aqueous environments | Nature Nanotechnology | 2011 | 145 |
Epidemiological trends of dengue disease in Brazil (2000-2010): a systematic literature search and analysis | PLoS Neglected Tropical Diseases | 2013 | 140 |
Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia | Science Translational Medicine | 2009 | 137 |
Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I/II trial | Clinical Cancer Research | 2006 | 134 |