| # | Title | Journal | Year | Citations |
|---|
| 1 | Photodynamic therapy of cancer: An update | Ca-A Cancer Journal for Clinicians | 2011 | 3,902 |
| 2 | BioGRID: a general repository for interaction datasets | Nucleic Acids Research | 2006 | 3,407 |
| 3 | OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis | Nature | 1999 | 3,093 |
| 4 | Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin | Nature | 1997 | 3,053 |
| 5 | Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4 | Science | 1995 | 2,587 |
| 6 | The Biochemistry of P-Glycoprotein-Mediated Multidrug Resistance | Annual Review of Biochemistry | 1989 | 2,051 |
| 7 | Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4 | Journal of Experimental Medicine | 2000 | 1,977 |
| 8 | GSK-3: tricks of the trade for a multi-tasking kinase | Journal of Cell Science | 2003 | 1,862 |
| 9 | Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand | Nature | 1999 | 1,809 |
| 10 | Erlotinib in Lung Cancer — Molecular and Clinical Predictors of Outcome | New England Journal of Medicine | 2005 | 1,787 |
| 11 | BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis | Molecular Cell | 2001 | 1,535 |
| 12 | Activatable Photosensitizers for Imaging and Therapy | Chemical Reviews | 2010 | 1,483 |
| 13 | The genetic basis of early T-cell precursor acute lymphoblastic leukaemia | Nature | 2012 | 1,430 |
| 14 | The CRAPome: a contaminant repository for affinity purification–mass spectrometry data | Nature Methods | 2013 | 1,353 |
| 15 | Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation | Nature | 2000 | 1,346 |
| 16 | Reflecting on 25 years with MYC | Nature Reviews Cancer | 2008 | 1,326 |
| 17 | Acid pH in tumors and its potential for therapeutic exploitation | Cancer Research | 1989 | 1,305 |
| 18 | Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells | Current Biology | 1996 | 1,248 |
| 19 | Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death | Nature | 2001 | 1,212 |
| 20 | Differential T cell costimulatory requirements in CD28-deficient mice | Science | 1993 | 1,188 |
| 21 | DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2 | Science | 2000 | 1,172 |
| 22 | A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 | Nature | 2008 | 1,169 |
| 23 | An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid | Nature Immunology | 2003 | 1,139 |
| 24 | Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells | Nature | 2004 | 1,084 |
| 25 | Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun | Nature | 1994 | 1,016 |
| 26 | Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation | Biochemical Journal | 1998 | 1,014 |
| 27 | Function of PI3K in Thymocyte Development, T Cell Activation, and Neutrophil Migration | Science | 2000 | 1,003 |
| 28 | Retinal Stem Cells in the Adult Mammalian Eye | Science | 2000 | 994 |
| 29 | Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines | Science | 1983 | 959 |
| 30 | Separation of cells by velocity sedimentation | Journal of Cellular Physiology | 1969 | 941 |
| 31 | Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span | Current Biology | 1998 | 939 |
| 32 | Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies | Nature | 1985 | 899 |
| 33 | Stem cell gene expression programs influence clinical outcome in human leukemia | Nature Medicine | 2011 | 894 |
| 34 | Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens | Cell Stem Cell | 2009 | 881 |
| 35 | Cytochrome c: functions beyond respiration | Nature Reviews Molecular Cell Biology | 2008 | 875 |
| 36 | The physics, biophysics and technology of photodynamic therapy | Physics in Medicine and Biology | 2008 | 849 |
| 37 | Regulation of PTEN Transcription by p53 | Molecular Cell | 2001 | 815 |
| 38 | Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta | Science | 1995 | 810 |
| 39 | Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation | Cell | 1995 | 809 |
| 40 | Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines | Nature | 1985 | 801 |
| 41 | Pathogenetic mechanisms in thyroid follicular-cell neoplasia | Nature Reviews Cancer | 2006 | 797 |
| 42 | Hypoxia signalling through mTOR and the unfolded protein response in cancer | Nature Reviews Cancer | 2008 | 787 |
| 43 | A Census of Human Soluble Protein Complexes | Cell | 2012 | 781 |
| 44 | Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice | Immunity | 1997 | 778 |
| 45 | Consistent blind protein structure generation from NMR chemical shift data | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 776 |
| 46 | Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 | Nature | 2002 | 766 |
| 47 | Exploring the role of cancer stem cells in radioresistance | Nature Reviews Cancer | 2008 | 766 |
| 48 | Regulation of tumour necrosis factor signalling: live or let die | Nature Reviews Immunology | 2015 | 761 |
| 49 | High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Current Biology | 1998 | 758 |
| 50 | TNF and ROS Crosstalk in Inflammation | Trends in Cell Biology | 2016 | 731 |
