| # | Title | Journal | Year | Citations |
|---|
| 1 | Mining electronic health records: towards better research applications and clinical care | Nature Reviews Genetics | 2012 | 1,226 |
| 2 | ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA | Cell | 2013 | 714 |
| 3 | Plasma Proteome Profiling to Assess Human Health and Disease | Cell Systems | 2016 | 549 |
| 4 | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours | Nature | 2017 | 498 |
| 5 | Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns | Cell Reports | 2012 | 493 |
| 6 | DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity | Cell | 2018 | 349 |
| 7 | Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage | Nature | 2015 | 317 |
| 8 | Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues | Nature Communications | 2012 | 307 |
| 9 | KinomeXplorer: an integrated platform for kinome biology studies | Nature Methods | 2014 | 304 |
| 10 | Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer | Journal of Proteome Research | 2012 | 270 |
| 11 | A Novel LC System Embeds Analytes in Pre-formed Gradients for Rapid, Ultra-robust Proteomics | Molecular and Cellular Proteomics | 2018 | 270 |
| 12 | A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin | Endocrinology | 2012 | 269 |
| 13 | Off-Line High-pH Reversed-Phase Fractionation for In-Depth Phosphoproteomics | Journal of Proteome Research | 2014 | 263 |
| 14 | Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation | Molecular Systems Biology | 2022 | 261 |
| 15 | Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries | Nature Communications | 2020 | 251 |
| 16 | Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells | Science Signaling | 2016 | 241 |
| 17 | Benchmarking common quantification strategies for large-scale phosphoproteomics | Nature Communications | 2018 | 232 |
| 18 | OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling | Molecular Cell | 2013 | 209 |
| 19 | Proteomics reveals the effects of sustained weight loss on the human plasma proteome | Molecular Systems Biology | 2016 | 188 |
| 20 | Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links | Science | 2015 | 183 |
| 21 | Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing | Chemistry and Biology | 2011 | 173 |
| 22 | Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies | EMBO Molecular Medicine | 2019 | 171 |
| 23 | A Map of General and Specialized Chromatin Readers in Mouse Tissues Generated by Label-free Interaction Proteomics | Molecular Cell | 2013 | 170 |
| 24 | LEDGF (p75) promotes DNA-end resection and homologous recombination | Nature Structural and Molecular Biology | 2012 | 169 |
| 25 | Deep Visual Proteomics defines single-cell identity and heterogeneity | Nature Biotechnology | 2022 | 160 |
| 26 | X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis | Clinical Immunology | 2013 | 158 |
| 27 | DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks | Nature Structural and Molecular Biology | 2012 | 153 |
| 28 | ADP‐ribosyltransferases, an update on function and nomenclature | FEBS Journal | 2022 | 150 |
| 29 | Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs | Molecular Cell | 2013 | 145 |
| 30 | Site-specific characterization of endogenous SUMOylation across species and organs | Nature Communications | 2018 | 139 |
| 31 | Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts | Nature Communications | 2020 | 138 |
| 32 | Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation | Nature Communications | 2019 | 129 |
| 33 | Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data | Journal of Proteome Research | 2019 | 128 |
| 34 | The proteome landscape of the kingdoms of life | Nature | 2020 | 128 |
| 35 | Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition | Structure | 2013 | 127 |
| 36 | Redox-sensitive alteration of replisome architecture safeguards genome integrity | Science | 2017 | 127 |
| 37 | A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1 | Genome Biology | 2011 | 123 |
| 38 | Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation | Cell Reports | 2018 | 123 |
| 39 | Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase | Circulation | 2020 | 121 |
| 40 | An Advanced Strategy for Comprehensive Profiling of ADP-ribosylation Sites Using Mass Spectrometry-based Proteomics* | Molecular and Cellular Proteomics | 2019 | 113 |
| 41 | DNA damage–inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger | Journal of Cell Biology | 2012 | 109 |
| 42 | RNF4 is required for DNA double-strand break repair in vivo | Cell Death and Differentiation | 2013 | 102 |
| 43 | Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking | Nature Structural and Molecular Biology | 2016 | 98 |
| 44 | A knowledge graph to interpret clinical proteomics data | Nature Biotechnology | 2022 | 97 |
| 45 | Dose-Specific Adverse Drug Reaction Identification in Electronic Patient Records: Temporal Data Mining in an Inpatient Psychiatric Population | Drug Safety | 2014 | 96 |
| 46 | High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion | EMBO Molecular Medicine | 2021 | 92 |
| 47 | Palaeoproteomics resolves sloth relationships | Nature Ecology and Evolution | 2019 | 91 |
| 48 | The Case for Proteomics and Phospho‐Proteomics in Personalized Cancer Medicine | Proteomics - Clinical Applications | 2019 | 88 |
| 49 | PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA | Molecular Cell | 2013 | 86 |
| 50 | Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer | Cell Reports | 2017 | 81 |
