| # | Title | Journal | Year | Citations |
|---|
| 1 | Surfing the p53 network | Nature | 2000 | 6,352 |
| 2 | A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity | Science | 2007 | 3,884 |
| 3 | GLUTATHIONE TRANSFERASES | Annual Review of Pharmacology and Toxicology | 2005 | 3,104 |
| 4 | The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I | Critical Reviews in Biochemistry and Molecular Biology | 1995 | 3,080 |
| 5 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 6 | Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis | Nature Genetics | 2006 | 2,584 |
| 7 | Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression | NeuroSignals | 2013 | 2,288 |
| 8 | Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. | Circulation | 1994 | 2,056 |
| 9 | Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals | Nature Genetics | 2018 | 1,835 |
| 10 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 11 | The Nrf2 regulatory network provides an interface between redox and intermediary metabolism | Trends in Biochemical Sciences | 2014 | 1,591 |
| 12 | Human osteoblast-like cells phagocytose metal particles and express the macrophage marker CD68 in vitro | Journal of Bone and Joint Surgery: British Volume | 2000 | 1,590 |
| 13 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 14 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial | Lancet, The | 2009 | 1,292 |
| 15 | Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress | Free Radical Research | 1999 | 1,276 |
| 16 | Oxidative Stress in Cancer | Cancer Cell | 2020 | 1,203 |
| 17 | Common variants near MC4R are associated with fat mass, weight and risk of obesity | Nature Genetics | 2008 | 1,179 |
| 18 | p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription | Journal of Biological Chemistry | 2010 | 1,158 |
| 19 | The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials | Lancet Oncology, The | 2013 | 1,141 |
| 20 | Guidelines for the management of inflammatory bowel disease in adults | Gut | 2011 | 1,127 |
| 21 | The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands | Nucleic Acids Research | 2016 | 1,075 |
| 22 | Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002) | Gut | 2010 | 1,000 |
| 23 | Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle | FASEB Journal | 2005 | 968 |
| 24 | Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression | Journal of Biological Chemistry | 2003 | 963 |
| 25 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 26 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 27 | Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial | Lancet, The | 1996 | 951 |
| 28 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 29 | Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris | Nature Genetics | 2006 | 916 |
| 30 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial | Lancet, The | 2009 | 906 |
| 31 | Glutathione S-Transferase Polymorphisms and Their Biological Consequences | Pharmacology | 2000 | 863 |
| 32 | Exercise for depression | The Cochrane Library | 2013 | 859 |
| 33 | The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial | Lancet, The | 2007 | 850 |
| 34 | The cytoprotective role of the Keap1–Nrf2 pathway | Archives of Toxicology | 2011 | 830 |
| 35 | The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease | BMJ: British Medical Journal | 2008 | 825 |
| 36 | Systemic Adverse Effects of Inhaled Corticosteroid Therapy | Archives of Internal Medicine | 1999 | 819 |
| 37 | Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 | Journal of Allergy and Clinical Immunology | 2020 | 783 |
| 38 | The benefits and harms of breast cancer screening: an independent review | British Journal of Cancer | 2013 | 767 |
| 39 | NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer | Trends in Biochemical Sciences | 2009 | 764 |
| 40 | Generation and Application of Data on Biological Variation in Clinical Chemistry | Critical Reviews in Clinical Laboratory Sciences | 1989 | 759 |
| 41 | Chronic post-surgical pain: 10 years on | British Journal of Anaesthesia | 2008 | 758 |
| 42 | Thrombophilia in pregnancy: a systematic review | British Journal of Haematology | 2006 | 743 |
| 43 | Genome-wide association analysis identifies 20 loci that influence adult height | Nature Genetics | 2008 | 742 |
| 44 | Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial | Lancet, The | 2014 | 740 |
| 45 | Diabetes and cognitive dysfunction | Lancet, The | 2012 | 722 |
| 46 | Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases | Oncogene | 2007 | 686 |
| 47 | Neurosteroids and GABAA receptor function | Trends in Pharmacological Sciences | 1995 | 680 |
| 48 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial | Lancet, The | 2010 | 677 |
| 49 | p53 isoforms can regulate p53 transcriptional activity | Genes and Development | 2005 | 671 |
| 50 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease | Free Radical Biology and Medicine | 2015 | 661 |
