| # | Title | Journal | Year | Citations |
|---|
| 1 | Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950 | Nature | 1978 | 358 |
| 2 | Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma | Carcinogenesis | 2002 | 199 |
| 3 | Power comparisons for disease clustering tests | Computational Statistics and Data Analysis | 2003 | 195 |
| 4 | A class of tests for detecting ‘general’ and ‘focused’ clustering of rare diseases | Statistics in Medicine | 1995 | 181 |
| 5 | Equivalence test and confidence interval for the difference in proportions for the paired-sample design | | 1998 | 175 |
| 6 | Identification of the second major allergen of Japanese cedar pollen | Allergy: European Journal of Allergy and Clinical Immunology | 1990 | 171 |
| 7 | Cigarette Smoking as a Risk Factor for Stroke Death in Japan | Stroke | 2004 | 171 |
| 8 | A test for spatial disease clustering adjusted for multiple testing | | 2000 | 132 |
| 9 | Identification of a novel gene, dep, associated with depolymerization of the capsular polymer in Bacillus anthracis | Molecular Microbiology | 1993 | 124 |
| 10 | Further isolation and characterization of temperature-sensitive mutants of influenza virus | Virology | 1975 | 105 |
| 11 | Neurovirulence of influenza virus in mice I. Neurovirulence of recombinants between virulent and avirulent virus strains | Virology | 1980 | 105 |
| 12 | Outbreaks of Norwalk-like virus-associated gastroenteritis traced to shellfish: coexistence of two genotypes in one specimen | Epidemiology and Infection | 1996 | 103 |
| 13 | Equivalence test and confidence interval for the difference in proportions for the paired‐sample design | Statistics in Medicine | 1998 | 103 |
| 14 | Contributions of social context to inequality in dental caries: a multilevel analysis of Japanese 3‐year‐old children | Community Dentistry and Oral Epidemiology | 2008 | 97 |
| 15 | Sensitivity to two major allergens (Cry j I and Cry j II) in patients with Japanese cedar (Cryptomeria japonica) pollinosis | Clinical and Experimental Allergy | 1995 | 86 |
| 16 | Therapeutic effects of stronger neo-minophagen C at different doses on chronic hepatitis and liver cirrhosis | Hepatology Research | 2001 | 80 |
| 17 | The Effect of Operational Factors on Solid/Liquid Separation by Ultra-Membrane Filtration in a Biological Denitrification System for Collected Human Excreta Treatment Plants | Water Science and Technology | 1991 | 75 |
| 18 | Airborne cat ( I), dog ( I), and mite ( I and II) allergen levels in the homes of Japan | Journal of Allergy and Clinical Immunology | 1993 | 74 |
| 19 | Biochemical and physical properties of an activated sludge on settling characteristics | Water Research | 1976 | 73 |
| 20 | Falls in the institutionalized elderly in Japan | Archives of Gerontology and Geriatrics | 1986 | 70 |
| 21 | Stakeholder analysis for health research: Case studies from low- and middle-income countries | Public Health | 2010 | 69 |
| 22 | Porphyrias in Japan | Stem Cells | 1994 | 65 |
| 23 | Physiological responses and thermal sensations of the elderly in cold and hot environments | Journal of Thermal Biology | 1993 | 64 |
| 24 | Neurovirulence of influenza virus in mice II. Mechanism of virulence as studied in a neuroblastoma cell line | Virology | 1980 | 63 |
| 25 | Thermoregulation during heat exposure of young children compared to their mothers | European Journal of Applied Physiology and Occupational Physiology | 1995 | 59 |
| 26 | Measurements of atmospheric SO2 and SO42−, and determination of the wet scavenging coefficient of sulfate aerosols for the winter monsoon season over the sea of Japan | Atmospheric Environment | 1996 | 59 |
| 27 | Detection of Influenza Viruses in Throat Swab by Using Polymerase Chain Reaction | Microbiology and Immunology | 1991 | 58 |
| 28 | Using Exhaled Nitric Oxide and Serum Periostin as a Composite Marker to Identify Severe/Steroid-Insensitive Asthma | American Journal of Respiratory and Critical Care Medicine | 2014 | 55 |
| 29 | Concentration of airborne mite allergens (Der I and Der II) during sleep | Allergy: European Journal of Allergy and Clinical Immunology | 1992 | 54 |
| 30 | The Concentration of Common Cesium and Rubidium in Human Body | Journal of Radiation Research | 1962 | 53 |
| 31 | The roles of microbes in the removal and inactivation of viruses in a biological wastewater treatment system | Water Science and Technology | 1996 | 49 |
| 32 | Measurement of antigen-specific mouse IgE by a fluorometric reverse (IgE-capture) ELISA | Journal of Immunological Methods | 1989 | 48 |
| 33 | Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study | British Journal of Cancer | 2003 | 48 |
| 34 | HPV Knowledge and Behaviors of Black College Students at a Historically Black University | Journal of American College Health | 2007 | 48 |
| 35 | Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men | International Journal of Medical Sciences | 2007 | 47 |
| 36 | Prognostic significance of the PC10 index as a prospective assay for cervical cancer treated with radiation therapy alone | Cancer | 1992 | 46 |
| 37 | Protective Effect of Bifidobacterium-Monoassociation against Lethal Activity of Escherichia coli | Bifidobacteria and Microflora | 1982 | 45 |
| 38 | Simultaneous determination of nalidixic acid, oxolinic acid and piromidic acid in fish by high-performance liquid chromatography with fluorescence and uv detection | Journal of Chromatography A | 1987 | 42 |
| 39 | Identification of the binding sites to monoclonal antibodies on A/USSR/90/77 (H1N1) hemagglutinin and their involvement in antigenic drift in H1N1 influenza viruses | Virology | 1983 | 41 |
| 40 | Microphotoelectric plethysmography using a rabbit ear chamber | Journal of Applied Physiology | 1965 | 40 |
| 41 | Existence of exine-free airborne allergen particles of Japanese cedar (Cryptomeria japonica) pollen | Allergy: European Journal of Allergy and Clinical Immunology | 1991 | 40 |
| 42 | Mutagenicity of the photochemical reaction products of pyrene with nitrogen dioxide | Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental Or Occupational Exposure | 1986 | 39 |
| 43 | Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study | BMJ Open | 2014 | 39 |
| 44 | Growth and nutrient uptake of green alga, Scenedesmus dimorphus, under a wide range of nitrogen/phosphorus ratio—I. Experimental study | Water Research | 1984 | 38 |
| 45 | Genetic relatedness between A/Swine/Iowa/15/30(H1N1) and human influenza viruses | Virology | 1984 | 37 |
| 46 | The mutagenicity of indoor air particles in a residential pilot field study: Application and evaluation of new methodologies | Atmospheric Environment | 1987 | 37 |
| 47 | A facile synthesis of δ-aminolevulinic acid (ALA) regioselectively labeled with 13C and direct observation of enzymatic transformation from ALA to porphobilinogen (PBG) | Journal of Labelled Compounds and Radiopharmaceuticals | 1989 | 37 |
| 48 | Three-factor cross of influenza virus | Virology | 1977 | 36 |
| 49 | Stimulation of human lymphocytes by cathepsin G | Cellular Immunology | 1995 | 36 |
| 50 | Health Risk Appraisal Models for Mass Screening for Esophageal and Pharyngeal Cancer: An Endoscopic Follow-up Study of Cancer-Free Japanese Men | Cancer Epidemiology Biomarkers and Prevention | 2009 | 35 |
