| # | Title | Journal | Year | Citations |
|---|
| 1 | B cells and tertiary lymphoid structures promote immunotherapy response | Nature | 2020 | 1,421 |
| 2 | Tertiary lymphoid structures improve immunotherapy and survival in melanoma | Nature | 2020 | 1,209 |
| 3 | Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12 | Immunity | 2018 | 639 |
| 4 | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death | Immunity | 2020 | 610 |
| 5 | Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study | Nature Methods | 2014 | 564 |
| 6 | Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses | Science | 2009 | 473 |
| 7 | Predicting distant recurrence in receptor-positive breast cancer patients with limited clinicopathological risk: using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone | Annals of Oncology | 2014 | 326 |
| 8 | Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity | Genome Research | 2011 | 269 |
| 9 | Comparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor–Positive Breast Cancer | JAMA Oncology | 2018 | 246 |
| 10 | Seven-Year Follow-Up Analysis of Adjuvant Paclitaxel and Trastuzumab Trial for Node-Negative, Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer | Journal of Clinical Oncology | 2019 | 229 |
| 11 | Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy | Cell Reports | 2019 | 189 |
| 12 | The PAM50 Risk-of-Recurrence Score Predicts Risk for Late Distant Recurrence after Endocrine Therapy in Postmenopausal Women with Endocrine-Responsive Early Breast Cancer | Clinical Cancer Research | 2014 | 182 |
| 13 | High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging | Nature Biotechnology | 2022 | 144 |
| 14 | The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 | Stem Cell Reports | 2022 | 138 |
| 15 | Multiplexed measurements of gene signatures in different analytes using the Nanostring nCounter™ Assay System | BMC Research Notes | 2009 | 136 |
| 16 | A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis | Nature Medicine | 2019 | 133 |
| 17 | Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions | Nature Communications | 2021 | 132 |
| 18 | High-Plex Predictive Marker Discovery for Melanoma Immunotherapy–Treated Patients Using Digital Spatial Profiling | Clinical Cancer Research | 2019 | 117 |
| 19 | Identification of Sensitive Serum microRNA Biomarkers for Radiation Biodosimetry | PLoS ONE | 2013 | 111 |
| 20 | Identifying clinically relevant prognostic subgroups of postmenopausal women with node-positive hormone receptor-positive early-stage breast cancer treated with endocrine therapy: a combined analysis of ABCSG-8 and ATAC using the PAM50 risk of recurrence score and intrinsic subtype | Annals of Oncology | 2015 | 108 |
| 21 | Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment | Nature Genetics | 2022 | 107 |
| 22 | A perturbation model of the gene regulatory network for oral and aboral ectoderm specification in the sea urchin embryo | Developmental Biology | 2009 | 100 |
| 23 | Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data | Nature Communications | 2022 | 100 |
| 24 | The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort | Journal of Translational Medicine | 2019 | 88 |
| 25 | Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay | Clinical Cancer Research | 2016 | 79 |
| 26 | The Immune Microenvironment in Hormone Receptor–Positive Breast Cancer Before and After Preoperative Chemotherapy | Clinical Cancer Research | 2019 | 76 |
| 27 | Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth | Cancer Research | 2016 | 74 |
| 28 | Biomarkers Associated with Beneficial PD-1 Checkpoint Blockade in Non–Small Cell Lung Cancer (NSCLC) Identified Using High-Plex Digital Spatial Profiling | Clinical Cancer Research | 2020 | 73 |
| 29 | Modeling Bi-modality Improves Characterization of Cell Cycle on Gene Expression in Single Cells | PLoS Computational Biology | 2014 | 70 |
| 30 | Assessment of the Feasibility and Safety of Durvalumab for Treatment of Solid Tumors in Patients With HIV-1 Infection | JAMA Oncology | 2020 | 70 |
| 31 | Molecular Drivers of Oncotype DX, Prosigna, EndoPredict, and the Breast Cancer Index: A TransATAC Study | Journal of Clinical Oncology | 2021 | 69 |
| 32 | Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples | Acta Neuropathologica | 2019 | 68 |
| 33 | Analysis of the DNA sequence and duplication history of human chromosome 15 | Nature | 2006 | 67 |
| 34 | Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma | Nature Medicine | 2021 | 64 |
| 35 | Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets | Nature Cancer | 2020 | 58 |
| 36 | SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice | Science Translational Medicine | 2022 | 55 |
| 37 | Continuously tunable nucleic acid hybridization probes | Nature Methods | 2015 | 48 |
| 38 | Genes related to mitochondrial functions are differentially expressed in phosphine-resistant and -susceptible Tribolium castaneum | BMC Genomics | 2015 | 47 |
| 39 | Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells | Oncotarget | 2015 | 47 |
| 40 | A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease | Molecular Neurodegeneration | 2020 | 45 |
| 41 | CD56dim CD16− Natural Killer Cell Profiling in Melanoma Patients Receiving a Cancer Vaccine and Interferon-α | Frontiers in Immunology | 2019 | 41 |
| 42 | Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response | Nature Cancer | 2021 | 41 |
| 43 | Phase Ib/II trial testing combined radiofrequency ablation and ipilimumab in uveal melanoma (SECIRA-UM) | Melanoma Research | 2020 | 37 |
| 44 | G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation | Nucleic Acids Research | 2016 | 36 |
| 45 | DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression | Cell Reports | 2019 | 34 |
| 46 | Molecular Subtypes and Genomic Profile of Primary Central Nervous System Lymphoma | Journal of Neuropathology and Experimental Neurology | 2020 | 33 |
| 47 | Validation of a prognostic multi‐gene signature in high‐risk neuroblastoma using the high throughput digital NanoString nCounter™ system | Molecular Oncology | 2014 | 32 |
| 48 | PAM50 breast cancer intrinsic subtypes and effect of gemcitabine in advanced breast cancer patients | Acta Oncológica | 2014 | 28 |
| 49 | Facile semi-automated forensic body fluid identification by multiplex solution hybridization of NanoString® barcode probes to specific mRNA targets | Forensic Science International: Genetics | 2015 | 28 |
| 50 | A Comprehensive Analysis of Baseline Clinical Characteristics and Biomarkers Associated with Outcome in Advanced Melanoma Patients Treated with Pembrolizumab | Cancers | 2021 | 24 |
