| # | Title | Journal | Year | Citations |
|---|
| 1 | Signal transduction by receptors with tyrosine kinase activity | Cell | 1990 | 5,482 |
| 2 | Cell Signaling by Receptor Tyrosine Kinases | Cell | 2000 | 3,724 |
| 3 | Identification of a major co-receptor for primary isolates of HIV-1 | Nature | 1996 | 3,667 |
| 4 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene | Nature | 1984 | 3,227 |
| 5 | Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial | Lancet, The | 2016 | 3,077 |
| 6 | The human microbiome: at the interface of health and disease | Nature Reviews Genetics | 2012 | 2,798 |
| 7 | Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck | New England Journal of Medicine | 2004 | 2,756 |
| 8 | Toward discovery science of human brain function | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 2,703 |
| 9 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 10 | Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development | Nature | 1998 | 2,303 |
| 11 | An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics | Cell | 2018 | 2,277 |
| 12 | DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells | Cell | 2000 | 2,214 |
| 13 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function | Science | 1988 | 2,172 |
| 14 | Simultaneous epitope and transcriptome measurement in single cells | Nature Methods | 2017 | 2,124 |
| 15 | Macrophages in the Pathogenesis of Atherosclerosis | Cell | 2011 | 2,122 |
| 16 | Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF | Science | 1999 | 2,020 |
| 17 | A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 | 2,012 |
| 18 | Pain and Its Treatment in Outpatients with Metastatic Cancer | New England Journal of Medicine | 1994 | 1,920 |
| 19 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 20 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 21 | Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations | Neoplasia | 2009 | 1,703 |
| 22 | A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex | Neuron | 2011 | 1,659 |
| 23 | The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling | Cell | 1992 | 1,624 |
| 24 | Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature | Journal of Neuropathology and Experimental Neurology | 2012 | 1,599 |
| 25 | Immune response in mice that lack the interferon-gamma receptor | Science | 1993 | 1,569 |
| 26 | Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial | Lancet, The | 2008 | 1,560 |
| 27 | MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,557 |
| 28 | Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences | Cell | 2014 | 1,493 |
| 29 | Production of the Alzheimer amyloid beta protein by normal proteolytic processing | Science | 1992 | 1,470 |
| 30 | Growth factor signaling by receptor tyrosine kinases | Neuron | 1992 | 1,465 |
| 31 | Acute pancreatitis: value of CT in establishing prognosis. | Radiology | 1990 | 1,420 |
| 32 | Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 1,407 |
| 33 | SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Nature Cell Biology | 1999 | 1,405 |
| 34 | 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial | Lancet, The | 2015 | 1,388 |
| 35 | Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures | Circulation | 2002 | 1,383 |
| 36 | Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions | Nature | 1995 | 1,362 |
| 37 | Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type | Science | 1990 | 1,323 |
| 38 | Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex | Nature | 2002 | 1,322 |
| 39 | Diversity and ubiquity of K channels | Neuroscience | 1988 | 1,316 |
| 40 | Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study | Lancet Oncology, The | 2016 | 1,279 |
| 41 | RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain | Nature Medicine | 2003 | 1,277 |
| 42 | Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2 | European Urology | 2019 | 1,270 |
| 43 | BRAF mutation predicts sensitivity to MEK inhibition | Nature | 2006 | 1,264 |
| 44 | Molecular definitions of autophagy and related processes | EMBO Journal | 2017 | 1,230 |
| 45 | A Randomized Trial Comparing Ticlopidine Hydrochloride with Aspirin for the Prevention of Stroke in High-Risk Patients | New England Journal of Medicine | 1989 | 1,224 |
| 46 | Biology and biochemistry of proteinases in tumor invasion | Physiological Reviews | 1993 | 1,204 |
| 47 | JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin | Cell | 1993 | 1,190 |
| 48 | HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 1,171 |
| 49 | A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development | Journal of Experimental Medicine | 2006 | 1,128 |
| 50 | STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma | Cancer Discovery | 2018 | 1,108 |
