| # | Title | Journal | Year | Citations |
|---|
| 1 | Human DNA methylomes at base resolution show widespread epigenomic differences | Nature | 2009 | 4,063 |
| 2 | Histone modifications at human enhancers reflect global cell-type-specific gene expression | Nature | 2009 | 2,225 |
| 3 | Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences | Science | 2009 | 2,167 |
| 4 | Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells | Nature | 2011 | 1,442 |
| 5 | Chemically defined conditions for human iPSC derivation and culture | Nature Methods | 2011 | 1,234 |
| 6 | Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells | Cell Stem Cell | 2010 | 747 |
| 7 | Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells | Cell | 2013 | 689 |
| 8 | Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 612 |
| 9 | Gut microbial metabolites as multi-kingdom intermediates | Nature Reviews Microbiology | 2021 | 557 |
| 10 | NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs | Cell Stem Cell | 2008 | 446 |
| 11 | Large-Scale Multi-omic Analysis of COVID-19 Severity | Cell Systems | 2021 | 438 |
| 12 | Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment | Stem Cells | 2011 | 413 |
| 13 | Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications | Journal of Biomedical Optics | 2020 | 375 |
| 14 | Beyond the margins: real-time detection of cancer using targeted fluorophores | Nature Reviews Clinical Oncology | 2017 | 366 |
| 15 | Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm | Genome Biology | 2016 | 354 |
| 16 | Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions | Nature Protocols | 2012 | 313 |
| 17 | Human pluripotent stem cell-derived neural constructs for predicting neural toxicity | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 288 |
| 18 | SCnorm: robust normalization of single-cell RNA-seq data | Nature Methods | 2017 | 275 |
| 19 | A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells | Cell Stem Cell | 2010 | 269 |
| 20 | Evaluation of de novo transcriptome assemblies from RNA-Seq data | Genome Biology | 2014 | 256 |
| 21 | Proteomic and phosphoproteomic comparison of human ES and iPS cells | Nature Methods | 2011 | 254 |
| 22 | Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells | Cell Stem Cell | 2010 | 253 |
| 23 | Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function | Molecular Cell | 2016 | 241 |
| 24 | Biochemistry of Mitochondrial Coenzyme Q Biosynthesis | Trends in Biochemical Sciences | 2017 | 239 |
| 25 | Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells | Blood | 2011 | 231 |
| 26 | Comprehensive Single-Shot Proteomics with FAIMS on a Hybrid Orbitrap Mass Spectrometer | Analytical Chemistry | 2018 | 218 |
| 27 | FGF2 Sustains NANOG and Switches the Outcome of BMP4-Induced Human Embryonic Stem Cell Differentiation | Cell Stem Cell | 2011 | 216 |
| 28 | Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts | Cell Reports | 2017 | 187 |
| 29 | Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells | Stem Cell Reports | 2015 | 175 |
| 30 | Identification of the Hemogenic Endothelial Progenitor and Its Direct Precursor in Human Pluripotent Stem Cell Differentiation Cultures | Cell Reports | 2012 | 174 |
| 31 | Automated quantification of aligned collagen for human breast carcinoma prognosis | Journal of Pathology Informatics | 2014 | 172 |
| 32 | Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments | Nature Methods | 2015 | 171 |
| 33 | Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators | Nature Communications | 2014 | 160 |
| 34 | Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 150 |
| 35 | Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation | Clinical Cancer Research | 2019 | 145 |
| 36 | Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells | Stem Cells and Development | 2011 | 143 |
| 37 | Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors | Nature Communications | 2019 | 125 |
| 38 | Comparative RNA-seq Analysis in the Unsequenced Axolotl: The Oncogene Burst Highlights Early Gene Expression in the Blastema | PLoS Computational Biology | 2013 | 125 |
| 39 | Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling | Nature Biotechnology | 2016 | 122 |
| 40 | MicroRNA 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells | Stem Cells | 2009 | 119 |
| 41 | A predictive modeling approach for cell line-specific long-range regulatory interactions | Nucleic Acids Research | 2015 | 118 |
| 42 | Quantitative selection and parallel characterization of aptamers | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 115 |
| 43 | Quantitating the cell: turning images into numbers with ImageJ | Wiley Interdisciplinary Reviews: Developmental Biology | 2017 | 108 |
| 44 | Thermal Stability of Fibroblast Growth Factor Protein Is a Determinant Factor in Regulating Self-Renewal, Differentiation, and Reprogramming in Human Pluripotent Stem Cells | Stem Cells | 2012 | 107 |
| 45 | Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells | Stem Cell Reviews and Reports | 2015 | 107 |
| 46 | Functional characterization of human pluripotent stem cell-derived arterial endothelial cells | Proceedings of the National Academy of Sciences of the United States of America | 2017 | 105 |
| 47 | Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells | Stem Cell Reports | 2018 | 104 |
| 48 | Modeling Human Retinal Development with Patient-Specific Induced Pluripotent Stem Cells Reveals Multiple Roles for Visual System Homeobox 2 | Stem Cells | 2014 | 103 |
| 49 | Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model | OncoImmunology | 2019 | 103 |
| 50 | Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity | Molecular Cell | 2016 | 101 |
