| # | Title | Journal | Year | Citations |
|---|
|
| 1 | The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia | Schizophrenia Bulletin | 1987 | 18,261 |
| 2 | Remdesivir for the Treatment of Covid-19 — Final Report | New England Journal of Medicine | 2020 | 6,116 |
| 3 | Staphylococcus aureusInfections | New England Journal of Medicine | 1998 | 5,351 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 5 | ILAE Official Report: A practical clinical definition of epilepsy | Epilepsia | 2014 | 4,054 |
| 6 | ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 3,720 |
| 7 | Recent advances in the phencyclidine model of schizophrenia | American Journal of Psychiatry | 1991 | 2,723 |
| 8 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation | Cancer Cell | 2010 | 2,390 |
| 9 | Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 2,360 |
| 10 | Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 | Science | 2003 | 2,055 |
| 11 | Antibodies to von Willebrand Factor–Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura | New England Journal of Medicine | 1998 | 1,775 |
| 12 | 2011 Update to The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines | Annals of Thoracic Surgery | 2011 | 1,756 |
| 13 | A definition and classification of status epilepticus – Report of theILAETask Force on Classification of Status Epilepticus | Epilepsia | 2015 | 1,740 |
| 14 | Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer | New England Journal of Medicine | 2018 | 1,652 |
| 15 | Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura | Nature | 2001 | 1,635 |
| 16 | Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial | Lancet Oncology, The | 2019 | 1,595 |
| 17 | Subclinical Thyroid Disease | JAMA - Journal of the American Medical Association | 2004 | 1,547 |
| 18 | A Prospective Study of the Risk of Tuberculosis among Intravenous Drug Users with Human Immunodeficiency Virus Infection | New England Journal of Medicine | 1989 | 1,476 |
| 19 | Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections | American Journal of Gastroenterology | 2013 | 1,435 |
| 20 | Prospective Validation of a 21-Gene Expression Assay in Breast Cancer | New England Journal of Medicine | 2015 | 1,183 |
| 21 | The State of US Health, 1990-2016 | JAMA - Journal of the American Medical Association | 2018 | 1,119 |
| 22 | Mutations of optineurin in amyotrophic lateral sclerosis | Nature | 2010 | 1,116 |
| 23 | Nanotechnology as a therapeutic tool to combat microbial resistance | Advanced Drug Delivery Reviews | 2013 | 1,101 |
| 24 | Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development | Nature Medicine | 2015 | 1,089 |
| 25 | Update of the guidelines for lupus anticoagulant detection | Journal of Thrombosis and Haemostasis | 2009 | 1,074 |
| 26 | Determinants of Tumor Response and Survival With Erlotinib in Patients With Non—Small-Cell Lung Cancer | Journal of Clinical Oncology | 2004 | 1,046 |
| 27 | Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury | Critical Care | 2013 | 1,016 |
| 28 | Trends in Prescription Drug Use Among Adults in the United States From 1999-2012 | JAMA - Journal of the American Medical Association | 2015 | 1,005 |
| 29 | The Role of Chest Imaging in Patient Management During the COVID-19 Pandemic | Chest | 2020 | 906 |
| 30 | Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis | Lancet, The | 2010 | 880 |
| 31 | The Positive and Negative Syndrome Scale (PANSS): Rationale and Standardisation | British Journal of Psychiatry | 1989 | 877 |
| 32 | Reliability and validity of the positive and negative syndrome scale for schizophrenics | Psychiatry Research | 1988 | 875 |
| 33 | Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline | Annals of Thoracic Surgery | 2007 | 874 |
| 34 | Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit* | Critical Care Medicine | 2007 | 872 |
| 35 | Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2 | Science | 2002 | 835 |
| 36 | American College of Radiology White Paper on Radiation Dose in Medicine | Journal of the American College of Radiology | 2007 | 832 |
| 37 | Association Between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States | JAMA - Journal of the American Medical Association | 2017 | 818 |
| 38 | Rapid Detection of Mycobacterium tuberculosis and Rifampin Resistance by Use of On-Demand, Near-Patient Technology | Journal of Clinical Microbiology | 2010 | 804 |
| 39 | Transmission of Tuberculosis in New York City -- An Analysis by DNA Fingerprinting and Conventional Epidemiologic Methods | New England Journal of Medicine | 1994 | 793 |
| 40 | Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy | New England Journal of Medicine | 2016 | 770 |
| 41 | Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation | New England Journal of Medicine | 2016 | 770 |
| 42 | The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society | Radiology | 2020 | 770 |
| 43 | Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion | Blood | 1996 | 759 |
| 44 | Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 | Immunity | 2014 | 758 |
| 45 | Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US | JAMA Internal Medicine | 2020 | 754 |
| 46 | Instruction manual for the ILAE 2017 operational classification of seizure types | Epilepsia | 2017 | 752 |
| 47 | Epilepsy: new advances | Lancet, The | 2015 | 744 |
| 48 | Proposal for a New Classification of Outcome with Respect to Epileptic Seizures Following Epilepsy Surgery | Epilepsia | 2003 | 740 |
| 49 | Ticagrelor with or without Aspirin in High-Risk Patients after PCI | New England Journal of Medicine | 2019 | 733 |
| 50 | American Cancer Society Guidelines for the Early Detection of Cancer: Update of Early Detection Guidelines for Prostate, Colorectal, and Endometrial Cancers: ALSO: Update 2001--Testing for Early Lung Cancer Detection | Ca-A Cancer Journal for Clinicians | 2001 | 724 |
