| # | Title | Journal | Year | Citations |
|---|
| 1 | Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance | Journal of Clinical Investigation | 2003 | 3,195 |
| 2 | Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma | New England Journal of Medicine | 2008 | 1,787 |
| 3 | Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease | Nature | 2002 | 1,383 |
| 4 | The Leptin Receptor | Journal of Biological Chemistry | 1997 | 1,100 |
| 5 | Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island | Nature Immunology | 2004 | 1,091 |
| 6 | Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages | Nature Immunology | 2006 | 1,028 |
| 7 | Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma | Cancer Cell | 2007 | 941 |
| 8 | Modulation of A-type potassium channels by a family of calcium sensors | Nature | 2000 | 914 |
| 9 | Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma | Cancer Cell | 2007 | 899 |
| 10 | Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma | New England Journal of Medicine | 2016 | 861 |
| 11 | Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study | Lancet Oncology, The | 2011 | 835 |
| 12 | PTP1B Regulates Leptin Signal Transduction In Vivo | Developmental Cell | 2002 | 735 |
| 13 | Fit-for-Purpose Method Development and Validation for Successful Biomarker Measurement | Pharmaceutical Research | 2006 | 684 |
| 14 | T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells | Journal of Immunology | 2004 | 650 |
| 15 | Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids | PLoS Biology | 2005 | 590 |
| 16 | DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 | Nature Immunology | 2007 | 584 |
| 17 | Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells | Nature Genetics | 2005 | 575 |
| 18 | NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ | Cell | 2007 | 566 |
| 19 | Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet | Science | 2002 | 562 |
| 20 | De NovoPeptide Sequencing via Tandem Mass Spectrometry | Journal of Computational Biology | 1999 | 529 |
| 21 | Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides | Nature Genetics | 1999 | 503 |
| 22 | Two independent alleles at 6q23 associated with risk of rheumatoid arthritis | Nature Genetics | 2007 | 497 |
| 23 | Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial | Blood | 2007 | 485 |
| 24 | Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis | Diabetes | 1997 | 484 |
| 25 | A conserved dendritic-cell regulatory program limits antitumour immunity | Nature | 2020 | 476 |
| 26 | Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets | Nature Reviews Drug Discovery | 2011 | 456 |
| 27 | A role for Smad6 in development and homeostasis of the cardiovascular system | Nature Genetics | 2000 | 454 |
| 28 | The Need for Guidelines in Publication of Peptide and Protein Identification Data | Molecular and Cellular Proteomics | 2004 | 450 |
| 29 | Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains | Nature Genetics | 1997 | 394 |
| 30 | Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib | Blood | 2007 | 379 |
| 31 | Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study | Blood | 2006 | 373 |
| 32 | Enhancement of radiosensitivity by proteasome inhibition: Implications for a role of NF-κB | International Journal of Radiation Oncology Biology Physics | 2001 | 334 |
| 33 | A critical role for peptidoglycan N-deacetylation inListeriaevasion from the host innate immune system | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 329 |
| 34 | Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region | Blood Cells, Molecules, and Diseases | 1998 | 328 |
| 35 | Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma | Blood | 2008 | 315 |
| 36 | Dendritic Cells Injected Via Different Routes Induce Immunity in Cancer Patients | Journal of Immunology | 2001 | 314 |
| 37 | Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma | Blood | 2005 | 306 |
| 38 | Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues | Journal of Immunology | 2000 | 297 |
| 39 | Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues | Journal of Experimental Medicine | 2005 | 293 |
| 40 | Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients | Blood | 2010 | 286 |
| 41 | The transcriptional profile of early to middle sporulation in Bacillus subtilis | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 284 |
| 42 | Periventricular Heterotopia: An X-Linked Dominant Epilepsy Locus Causing Aberrant Cerebral Cortical Development | Neuron | 1996 | 280 |
| 43 | Expression Cloning of the STRL33/BONZO/TYMSTR Ligand Reveals Elements of CC, CXC, and CX3C Chemokines | Journal of Immunology | 2001 | 274 |
| 44 | Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis | Arthritis and Rheumatism | 2001 | 270 |
| 45 | Targeted Therapies for Cancer 2004 | American Journal of Clinical Pathology | 2004 | 261 |
| 46 | Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease | Genetics in Medicine | 2009 | 259 |
| 47 | NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury | Journal of Biological Chemistry | 2009 | 258 |
| 48 | Leptin Receptor (OB-R) Signaling | Journal of Biological Chemistry | 1997 | 257 |
| 49 | Intranasal Exposure of Mice to House Dust Mite Elicits Allergic Airway Inflammation via a GM-CSF-Mediated Mechanism | Journal of Immunology | 2004 | 250 |
| 50 | The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer | Oncogene | 1999 | 248 |
