| # | Title | Journal | Year | Citations |
|---|
| 1 | Determining a minimal important change in a disease-specific quality of life questionnaire | Journal of Clinical Epidemiology | 1994 | 1,639 |
| 2 | Measuring quality of life in children with asthma | Quality of Life Research | 1996 | 970 |
| 3 | Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer | Gastroenterology | 1998 | 865 |
| 4 | THE DOUBLE CRUSH IN NERVE-ENTRAPMENT SYNDROMES | Lancet, The | 1973 | 854 |
| 5 | The immune geography of IgA induction and function | Mucosal Immunology | 2008 | 838 |
| 6 | Measuring Quality of Life in Asthma | The American Review of Respiratory Disease | 1993 | 766 |
| 7 | Development of the human coagulation system in the healthy premature infant | Blood | 1988 | 684 |
| 8 | Dopamine visualized in the basal ganglia of living man | Nature | 1983 | 634 |
| 9 | Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer | Nature Medicine | 2013 | 634 |
| 10 | The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review | Gut | 2010 | 588 |
| 11 | Effect of Long-term Treatment with an Inhaled Corticosteroid (Budesonide) on Airway Hyperresponsiveness and Clinical Asthma in Nonsteroid-dependent Asthmatics | The American Review of Respiratory Disease | 1990 | 580 |
| 12 | Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? | ERJ Open Research | 2020 | 554 |
| 13 | 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2015 | 545 |
| 14 | Measuring quality of life in the parents of children with asthma | Quality of Life Research | 1996 | 544 |
| 15 | Appropriate Acid Suppression for the Management of Gastro-Oesophageal Reflux Disease | Digestion | 1992 | 514 |
| 16 | Oral Thrombin Inhibitor Dabigatran Etexilate vs North American Enoxaparin Regimen for Prevention of Venous Thromboembolism After Knee Arthroplasty Surgery | Journal of Arthroplasty | 2009 | 498 |
| 17 | Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis | Gut | 2009 | 486 |
| 18 | Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders. | American Journal of Respiratory and Critical Care Medicine | 1995 | 475 |
| 19 | Antibiotic Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis | American Journal of Gastroenterology | 2011 | 469 |
| 20 | Fetal Thrombocytopenia and Its Relation to Maternal Thrombocytopenia | New England Journal of Medicine | 1993 | 465 |
| 21 | Exercise Capacity and Ventilatory, Circulatory, and Symptom Limitation in Patients with Chronic Airflow Limitation | The American Review of Respiratory Disease | 1992 | 459 |
| 22 | IMPROVEMENT OF MEDICATION COMPLIANCE IN UNCONTROLLED HYPERTENSION | Lancet, The | 1976 | 443 |
| 23 | Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update) | Diabetes/Metabolism Research and Reviews | 2020 | 442 |
| 24 | Interventions for helping patients to follow prescriptions for medications | The Cochrane Library | 2002 | 440 |
| 25 | RANDOMISED CLINICAL TRIAL OF STRATEGIES FOR IMPROVING MEDICATION COMPLIANCE IN PRIMARY HYPERTENSION | Lancet, The | 1975 | 435 |
| 26 | Safety of Withholding Heparin in Pregnant Women with a History of Venous Thromboembolism | New England Journal of Medicine | 2000 | 409 |
| 27 | 2015 Gout Classification Criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatology | 2015 | 393 |
| 28 | The impact of anxiety disorders on educational achievement | Journal of Anxiety Disorders | 2003 | 390 |
| 29 | Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer | JAMA - Journal of the American Medical Association | 2015 | 390 |
| 30 | Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials | American Heart Journal | 2004 | 388 |
| 31 | Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4 | Blood | 1994 | 365 |
| 32 | Heparin-induced thrombocytopenia: laboratory studies | Blood | 1988 | 364 |
| 33 | Differences in diagnostic criteria for gastric carcinoma between Japanese and Western pathologists | Lancet, The | 1997 | 364 |
| 34 | Gastro-oesophageal reflux disease | Lancet, The | 2006 | 362 |
| 35 | Practical guidelines on the management and prevention of the diabetic foot 2011 | Diabetes/Metabolism Research and Reviews | 2012 | 349 |
| 36 | Heparin-induced thrombocytopenia: laboratory studies | Blood | 1988 | 339 |
| 37 | Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2007 | 338 |
| 38 | Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial | Lancet, The | 2008 | 333 |
| 39 | Estimation of test error rates, disease prevalence and relative risk from misclassified data: a review | Journal of Clinical Epidemiology | 1988 | 326 |
| 40 | Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator | Oncogene | 2000 | 322 |
| 41 | Management of Venous Thromboembolism | New England Journal of Medicine | 1996 | 321 |
| 42 | Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura | Lancet, The | 1994 | 315 |
| 43 | Molecular Detection of the ETV6-NTRK3 Gene Fusion Differentiates Congenital Fibrosarcoma From Other Childhood Spindle Cell Tumors | American Journal of Surgical Pathology | 2000 | 314 |
| 44 | A role for the gut microbiota in IBS | Nature Reviews Gastroenterology and Hepatology | 2014 | 304 |
| 45 | Quality of life issues in women with vertebral fractures due to osteoporosis | Arthritis and Rheumatism | 1993 | 297 |
| 46 | Hemispheric Specialization for Linguistic and Nonlinguistic Tactual Perception Using a Dichotomous Stimulation Technique | Cortex | 1974 | 296 |
| 47 | Frequency and mechanism of neonatal thrombocytopenia | Journal of Pediatrics | 1986 | 296 |
| 48 | Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans | Journal of Applied Physiology | 2010 | 296 |
| 49 | Interventions for enhancing medication adherence | | 2005 | 295 |
| 50 | High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression | Journal of Applied Physiology | 2011 | 292 |
