| # | Title | Journal | Year | Citations |
|---|
| 1 | Updated Clinical Classification of Pulmonary Hypertension | Journal of the American College of Cardiology | 2009 | 1,919 |
| 2 | Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer | New England Journal of Medicine | 2019 | 982 |
| 3 | EULAR revised recommendations for the management of fibromyalgia | Annals of the Rheumatic Diseases | 2017 | 880 |
| 4 | Multiple common variants for celiac disease influencing immune gene expression | Nature Genetics | 2010 | 871 |
| 5 | Can Anesthetic Technique for Primary Breast Cancer Surgery Affect Recurrence or Metastasis? | Anesthesiology | 2006 | 842 |
| 6 | Estimating cumulative point prevalence of rare diseases: analysis of the Orphanet database | European Journal of Human Genetics | 2020 | 716 |
| 7 | EULAR evidence-based recommendations for the management of fibromyalgia syndrome | Annals of the Rheumatic Diseases | 2008 | 639 |
| 8 | The Outcome of Neutrophil Gelatinase-Associated Lipocalin-Positive Subclinical Acute Kidney Injury | Journal of the American College of Cardiology | 2011 | 597 |
| 9 | Magnetic resonance imaging for clinical management of rectal cancer: Updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting | European Radiology | 2018 | 592 |
| 10 | Anesthetic Technique for Radical Prostatectomy Surgery Affects Cancer Recurrence | Anesthesiology | 2008 | 566 |
| 11 | Characterization of the Inflammatory Response to Severe COVID-19 Illness | American Journal of Respiratory and Critical Care Medicine | 2020 | 487 |
| 12 | Changing Demographics, Epidemiology, and Survival of Incident Pulmonary Arterial Hypertension | American Journal of Respiratory and Critical Care Medicine | 2012 | 483 |
| 13 | Pulmonary hypertension in chronic lung disease and hypoxia | European Respiratory Journal | 2019 | 428 |
| 14 | Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial | Lancet, The | 2020 | 400 |
| 15 | Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies | British Journal of Psychiatry | 2012 | 389 |
| 16 | Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing | Nature Reviews Drug Discovery | 2018 | 370 |
| 17 | Contrast-Induced Nephropathy | American Journal of Roentgenology | 2004 | 364 |
| 18 | Locoregional recurrence after breast cancer surgery: a systematic review by receptor phenotype | Breast Cancer Research and Treatment | 2012 | 333 |
| 19 | TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease | Molecular Neurodegeneration | 2013 | 323 |
| 20 | Intraoperative fluids: how much is too much? | British Journal of Anaesthesia | 2012 | 319 |
| 21 | The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years) | Intensive Care Medicine | 2017 | 311 |
| 22 | Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy | Circulation | 2016 | 307 |
| 23 | Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study | Lancet Neurology, The | 2011 | 294 |
| 24 | Effect of Margin Status on Local Recurrence After Breast Conservation and Radiation Therapy for Ductal Carcinoma In Situ | Journal of Clinical Oncology | 2009 | 292 |
| 25 | Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis? | British Journal of Anaesthesia | 2012 | 292 |
| 26 | Addition of brain and carotid imaging to the ABCD2 score to identify patients at early risk of stroke after transient ischaemic attack: a multicentre observational study | Lancet Neurology, The | 2010 | 251 |
| 27 | Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease | American Journal of Human Genetics | 2011 | 250 |
| 28 | Treatment Goals of Pulmonary Hypertension | Journal of the American College of Cardiology | 2013 | 250 |
| 29 | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial | BMJ, The | 2021 | 250 |
| 30 | Fibrogenesis in Crohn's Disease | American Journal of Gastroenterology | 2007 | 244 |
| 31 | Nontuberculous Pyogenic Spinal Infection in Adults | Spine | 2006 | 243 |
| 32 | Lrrk2 pathogenic substitutions in Parkinson's disease | Neurogenetics | 2005 | 237 |
| 33 | Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia | Intensive Care Medicine | 2010 | 235 |
| 34 | Radiotherapy and breast reconstruction: a meta-analysis | Breast Cancer Research and Treatment | 2011 | 234 |
| 35 | The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study | Intensive Care Medicine | 2020 | 230 |
| 36 | Prospective Derivation and Validation of a Clinical Prediction Rule for Recurrent Clostridium difficile Infection | Gastroenterology | 2009 | 222 |
| 37 | Magnetic resonance imaging for the clinical management of rectal cancer patients: recommendations from the 2012 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting | European Radiology | 2013 | 222 |
| 38 | Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample | British Journal of Psychiatry | 2008 | 218 |
| 39 | End Points and Clinical Trial Design in Pulmonary Arterial Hypertension | Journal of the American College of Cardiology | 2009 | 209 |
| 40 | Malignant distal biliary obstruction: A systematic review and meta-analysis of endoscopic and surgical bypass results | Cancer Treatment Reviews | 2007 | 207 |
| 41 | Trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer and brain metastases: exploratory final analysis of cohort 1 from KAMILLA, a single-arm phase IIIb clinical trial☆ | Annals of Oncology | 2020 | 206 |
| 42 | Injectable Corticosteroid and Local Anesthetic Preparations: A Review for Radiologists | Radiology | 2009 | 205 |
| 43 | Antithrombotic Therapy in Peripheral Artery Disease | Chest | 2012 | 204 |
| 44 | Emergence of a novel GII.17 norovirus – End of the GII.4 era? | Eurosurveillance | 2015 | 204 |
| 45 | Persistent Poor Health after COVID-19 Is Not Associated with Respiratory Complications or Initial Disease Severity | Annals of the American Thoracic Society | 2021 | 202 |
| 46 | Synovial tissue hypoxia and inflammation in vivo | Annals of the Rheumatic Diseases | 2010 | 198 |
| 47 | Current Etiologies and Modes of Failure in Total Knee Arthroplasty Revision | Clinical Orthopaedics and Related Research | 2006 | 197 |
| 48 | Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study | European Urology | 2014 | 195 |
| 49 | Do the benefits of metal stents justify the costs? A systematic review and meta-analysis of trials comparing endoscopic stents for malignant biliary obstruction | European Journal of Gastroenterology and Hepatology | 2007 | 182 |
| 50 | Anatomy and Bronchoscopy of the Porcine Lung. A Model for Translational Respiratory Medicine | American Journal of Respiratory Cell and Molecular Biology | 2014 | 176 |
