| # | Title | Journal | Year | Citations |
|---|
| 1 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 2 | Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer | New England Journal of Medicine | 2013 | 1,971 |
| 3 | Scale for the assessment and rating of ataxia: Development of a new clinical scale | Neurology | 2006 | 1,579 |
| 4 | Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells | Immunity | 1999 | 1,512 |
| 5 | Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 | Journal of Biological Chemistry | 2003 | 1,473 |
| 6 | Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 | Journal of Hepatology | 2018 | 1,157 |
| 7 | Construct validity of the Trail Making Test: Role of task-switching, working memory, inhibition/interference control, and visuomotor abilities | Journal of the International Neuropsychological Society | 2009 | 949 |
| 8 | The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data | Brain Imaging and Behavior | 2014 | 696 |
| 9 | Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists | Arthritis and Rheumatism | 2005 | 612 |
| 10 | Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial | Lancet, The | 2013 | 610 |
| 11 | MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program | Blood | 2013 | 596 |
| 12 | Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2019 | 594 |
| 13 | Effect of CPAP on Blood Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension | JAMA - Journal of the American Medical Association | 2013 | 567 |
| 14 | Terlipressin and Albumin vs Albumin in Patients With Cirrhosis and Hepatorenal Syndrome: A Randomized Study | Gastroenterology | 2008 | 541 |
| 15 | Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas | Nature Genetics | 2014 | 534 |
| 16 | Prevalence of Amyloid PET Positivity in Dementia Syndromes | JAMA - Journal of the American Medical Association | 2015 | 501 |
| 17 | Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma | New England Journal of Medicine | 2021 | 473 |
| 18 | Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer | Annals of Oncology | 2014 | 462 |
| 19 | 2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative | Annals of the Rheumatic Diseases | 2012 | 451 |
| 20 | Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data☆ | Cortex | 2010 | 420 |
| 21 | Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: Results of a three-year follow-up quasi-experimental study* | Critical Care Medicine | 2010 | 409 |
| 22 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis | Clinical Gastroenterology and Hepatology | 2012 | 407 |
| 23 | Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors | New England Journal of Medicine | 2017 | 405 |
| 24 | The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PDStudy) | Movement Disorders | 2015 | 402 |
| 25 | Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation | Journal of Biological Chemistry | 2002 | 396 |
| 26 | Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma | Cancer Cell | 2015 | 378 |
| 27 | Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology | 2017 | 371 |
| 28 | Mutations in BRIP1 confer high risk of ovarian cancer | Nature Genetics | 2011 | 338 |
| 29 | Klebsiella pneumoniae AcrAB Efflux Pump Contributes to Antimicrobial Resistance and Virulence | Antimicrobial Agents and Chemotherapy | 2010 | 332 |
| 30 | Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL | Journal of Experimental Medicine | 2000 | 331 |
| 31 | Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2 | Blood | 1996 | 328 |
| 32 | Pitx2 Participates in the Late Phase of the Pathway Controlling Left-Right Asymmetry | Cell | 1998 | 324 |
| 33 | The use of the Beck Depression Inventory to screen for depression in the general population: a preliminary analysis | Journal of Affective Disorders | 2000 | 324 |
| 34 | Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study | Blood | 2012 | 301 |
| 35 | Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study | Leukemia | 2012 | 301 |
| 36 | The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb | Development (Cambridge) | 1999 | 300 |
| 37 | Tivantinib for second-line treatment of MET-high, advanced hepatocellular carcinoma (METIV-HCC): a final analysis of a phase 3, randomised, placebo-controlled study | Lancet Oncology, The | 2018 | 285 |
| 38 | Obesity, Fat Mass and Immune System: Role for Leptin | Frontiers in Physiology | 2018 | 284 |
| 39 | Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study | Lancet Oncology, The | 2022 | 282 |
| 40 | Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019 | European Urology | 2020 | 278 |
| 41 | Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells | Oncogene | 2002 | 275 |
| 42 | A double-blind placebo controlled trial of etanercept in patients with giant cell arteritis and corticosteroid side effects | Annals of the Rheumatic Diseases | 2007 | 263 |
| 43 | A Prospective Randomized Trial of Drug-Eluting Balloons Versus Everolimus-Eluting Stents in Patients With In-Stent Restenosis of Drug-Eluting Stents | Journal of the American College of Cardiology | 2015 | 253 |
| 44 | Erythropoietin Can Induce the Expression of Bcl-xLthrough Stat5 in Erythropoietin-dependent Progenitor Cell Lines | Journal of Biological Chemistry | 1999 | 251 |
| 45 | A germline variant in the TP53 polyadenylation signal confers cancer susceptibility | Nature Genetics | 2011 | 251 |
| 46 | Cannabinoid receptors as novel targets for the treatment of melanoma | FASEB Journal | 2006 | 244 |
| 47 | Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus: a fiber dissection and DTI tractography study | Brain Structure and Function | 2013 | 239 |
| 48 | A randomized phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer | Annals of Oncology | 2009 | 237 |
| 49 | Spinocerebellar ataxia types 1, 2, 3, and 6 | Neurology | 2008 | 235 |
| 50 | Tracheal rupture after endotracheal intubation: a literature systematic review | European Journal of Cardio-thoracic Surgery | 2009 | 227 |
