| # | Title | Journal | Year | Citations |
|---|
| 1 | antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters | Nucleic Acids Research | 2015 | 1,764 |
| 2 | A community-driven global reconstruction of human metabolism | Nature Biotechnology | 2013 | 920 |
| 3 | The Systems Biology Graphical Notation | Nature Biotechnology | 2009 | 828 |
| 4 | The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics | Nature Chemistry | 2014 | 753 |
| 5 | Minimum Information about a Biosynthetic Gene cluster | Nature Chemical Biology | 2015 | 715 |
| 6 | Directed evolution drives the next generation of biocatalysts | Nature Chemical Biology | 2009 | 689 |
| 7 | A tutorial review: Metabolomics and partial least squares-discriminant analysis – a marriage of convenience or a shotgun wedding | Analytica Chimica Acta | 2015 | 618 |
| 8 | Towards the sustainable discovery and development of new antibiotics | Nature Reviews Chemistry | 2021 | 439 |
| 9 | On Splitting Training and Validation Set: A Comparative Study of Cross-Validation, Bootstrap and Systematic Sampling for Estimating the Generalization Performance of Supervised Learning | Journal of Analysis and Testing | 2018 | 423 |
| 10 | Metabolic fingerprinting as a diagnostic tool | Pharmacogenomics | 2007 | 361 |
| 11 | Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades | Science | 2015 | 339 |
| 12 | Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort | Allergy: European Journal of Allergy and Clinical Immunology | 2015 | 338 |
| 13 | Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways | ACS Catalysis | 2017 | 322 |
| 14 | Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes | Nature Chemistry | 2013 | 314 |
| 15 | Biocatalytic retrosynthesis | Nature Chemical Biology | 2013 | 299 |
| 16 | A reductive aminase from Aspergillus oryzae | Nature Chemistry | 2017 | 290 |
| 17 | Extending the application of biocatalysis to meet the challenges of drug development | Nature Reviews Chemistry | 2018 | 290 |
| 18 | Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts | ACS Catalysis | 2017 | 261 |
| 19 | Inhibition of protein aggregation and amyloid formation by small molecules | Current Opinion in Structural Biology | 2015 | 259 |
| 20 | The genetic expectations of a protracted model for the origins of domesticated crops | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 244 |
| 21 | Recon 2.2: from reconstruction to model of human metabolism | Metabolomics | 2016 | 243 |
| 22 | Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes | Physical Biology | 2008 | 225 |
| 23 | Cytochromes P450 as useful biocatalysts: addressing the limitations | Chemical Communications | 2011 | 221 |
| 24 | Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology | Current Opinion in Chemical Biology | 2016 | 212 |
| 25 | Three geographically separate domestications of Asian rice | Nature Plants | 2015 | 208 |
| 26 | Enantioselective Oxidation of C–O and C–N Bonds Using Oxidases | Chemical Reviews | 2011 | 204 |
| 27 | Molecular phenotyping of a UK population: defining the human serum metabolome | Metabolomics | 2015 | 202 |
| 28 | Imine reductases (IREDs) | Current Opinion in Chemical Biology | 2017 | 202 |
| 29 | Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals | Organic Process Research and Development | 2019 | 201 |
| 30 | Graphene in therapeutics delivery: Problems, solutions and future opportunities | European Journal of Pharmaceutics and Biopharmaceutics | 2016 | 197 |
| 31 | Deracemisation methods | Current Opinion in Chemical Biology | 2010 | 195 |
| 32 | Identification of a Major Epitope Recognized by PLA2R Autoantibodies in Primary Membranous Nephropathy | Journal of the American Society of Nephrology: JASN | 2015 | 185 |
| 33 | What makes a P450 tick? | Trends in Biochemical Sciences | 2013 | 181 |
| 34 | Exhaled breath analysis: a review of ‘breath-taking’ methods for off-line analysis | Metabolomics | 2017 | 178 |
| 35 | Can we identify patients at risk of life‐threatening allergic reactions to food? | Allergy: European Journal of Allergy and Clinical Immunology | 2016 | 176 |
| 36 | Ultrasensitive Colorimetric Detection of Murine Norovirus Using NanoZyme Aptasensor | Analytical Chemistry | 2019 | 174 |
| 37 | Hyaluronan | Cellular and Molecular Life Sciences | 2007 | 173 |
| 38 | The prevalence and distribution of food sensitization in European adults | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 172 |
| 39 | One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts | ACS Catalysis | 2016 | 171 |
| 40 | UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis | Nature | 2015 | 168 |
| 41 | The CHEMDNER corpus of chemicals and drugs and its annotation principles | Journal of Cheminformatics | 2015 | 166 |
| 42 | A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis | PLoS Computational Biology | 2014 | 164 |
| 43 | Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes | Journal of the American Chemical Society | 2016 | 164 |
| 44 | Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic tool | Analyst, The | 2013 | 163 |
| 45 | Simultaneously Enhancing Spectral Resolution and Sensitivity in Heteronuclear Correlation NMR Spectroscopy | Angewandte Chemie - International Edition | 2013 | 160 |
| 46 | An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals | Communications Biology | 2018 | 159 |
| 47 | A Regio‐ and Stereoselective ω‐Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5‐Disubstituted Pyrrolidines | Angewandte Chemie - International Edition | 2014 | 158 |
| 48 | Influence of Missing Values Substitutes on Multivariate Analysis of Metabolomics Data | Metabolites | 2014 | 158 |
| 49 | Rapid screening and scale-up of transaminase catalysed reactions | Organic and Biomolecular Chemistry | 2009 | 154 |
| 50 | Species identification of archaeological marine mammals using collagen fingerprinting | Journal of Archaeological Science | 2014 | 154 |
