| # | Title | Journal | Year | Citations |
|---|
| 1 | Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal | BMJ, The | 2020 | 2,134 |
| 2 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 3 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 4 | Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence | Journal of Investigative Dermatology | 2013 | 1,827 |
| 5 | Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials | New England Journal of Medicine | 2014 | 1,675 |
| 6 | Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men | New England Journal of Medicine | 2010 | 1,274 |
| 7 | Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 | World Journal of Surgery | 2019 | 1,166 |
| 8 | Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study | Lancet Psychiatry,the | 2020 | 1,005 |
| 9 | ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients | Clinical Microbiology and Infection | 2012 | 977 |
| 10 | Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease | New England Journal of Medicine | 2015 | 974 |
| 11 | Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease | Nature Genetics | 2017 | 943 |
| 12 | Controlled Interventions to Reduce Burnout in Physicians | JAMA Internal Medicine | 2017 | 898 |
| 13 | Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence | Nature Genetics | 2018 | 893 |
| 14 | Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 884 |
| 15 | Putting brain training to the test | Nature | 2010 | 875 |
| 16 | Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas | Acta Neuropathologica | 2012 | 863 |
| 17 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 848 |
| 18 | Calculating the sample size required for developing a clinical prediction model | BMJ, The | 2020 | 804 |
| 19 | Update of EULAR recommendations for the treatment of systemic sclerosis | Annals of the Rheumatic Diseases | 2017 | 794 |
| 20 | Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis | New England Journal of Medicine | 2010 | 773 |
| 21 | Dissecting the genomic complexity underlying medulloblastoma | Nature | 2012 | 765 |
| 22 | Treatable traits: toward precision medicine of chronic airway diseases | European Respiratory Journal | 2016 | 746 |
| 23 | Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials | Lancet, The | 2015 | 719 |
| 24 | Global burden of cancer attributable to high body-mass index in 2012: a population-based study | Lancet Oncology, The | 2015 | 718 |
| 25 | Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature | Nature Genetics | 2012 | 712 |
| 26 | Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction | JAMA Internal Medicine | 2018 | 705 |
| 27 | Definition of treatment goals for moderate to severe psoriasis: a European consensus | Archives of Dermatological Research | 2011 | 690 |
| 28 | The global problem of antifungal resistance: prevalence, mechanisms, and management | Lancet Infectious Diseases, The | 2017 | 670 |
| 29 | Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria | Clinical and Experimental Allergy | 2013 | 666 |
| 30 | Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management | European Respiratory Journal | 2016 | 654 |
| 31 | Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial | Nature Medicine | 2018 | 649 |
| 32 | Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies | International Journal of Epidemiology | 2019 | 643 |
| 33 | Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition | Cancer Cell | 2014 | 627 |
| 34 | Collaborative care for depression and anxiety problems | The Cochrane Library | 2012 | 624 |
| 35 | The clinical spectrum of pulmonary aspergillosis | Thorax | 2015 | 611 |
| 36 | Memantine for dementia | The Cochrane Library | 2006 | 608 |
| 37 | British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE | Thorax | 2013 | 601 |
| 38 | Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis | Lancet Oncology, The | 2016 | 592 |
| 39 | Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial | Lancet Oncology, The | 2012 | 584 |
| 40 | Association analyses based on false discovery rate implicate new loci for coronary artery disease | Nature Genetics | 2017 | 571 |
| 41 | Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007 | Clinical Microbiology and Infection | 2011 | 566 |
| 42 | High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis | Nature Genetics | 2012 | 558 |
| 43 | Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial | Lancet, The | 2016 | 556 |
| 44 | Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis | Nature Genetics | 2015 | 529 |
| 45 | Ketones and lactate “fuel” tumor growth and metastasis | Cell Cycle | 2010 | 526 |
| 46 | Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology | Journal of Antimicrobial Chemotherapy | 2014 | 525 |
| 47 | Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry | Annals of the Rheumatic Diseases | 2021 | 496 |
| 48 | Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling | Nature Genetics | 2014 | 490 |
| 49 | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function | Nature Communications | 2018 | 484 |
| 50 | Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study | Journal of Clinical Endocrinology and Metabolism | 2010 | 481 |
