| # | Title | Journal | Year | Citations |
|---|
| 1 | The consensus molecular subtypes of colorectal cancer | Nature Medicine | 2015 | 3,596 |
| 2 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,545 |
| 3 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 4 | Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers | JAMA - Journal of the American Medical Association | 2017 | 1,898 |
| 5 | Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study | Lancet, The | 2020 | 1,465 |
| 6 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 7 | EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 979 |
| 8 | Concordance of the Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health Surveys | International Journal of Methods in Psychiatric Research | 2006 | 949 |
| 9 | Multiple common variants for celiac disease influencing immune gene expression | Nature Genetics | 2010 | 871 |
| 10 | Hydatid Disease: Radiologic and Pathologic Features and Complications | Radiographics | 2000 | 754 |
| 11 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 711 |
| 12 | Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data | Lancet Oncology, The | 2014 | 703 |
| 13 | Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial | Lancet Oncology, The | 2015 | 699 |
| 14 | The International Workshop on Meibomian Gland Dysfunction: Report of the Definition and Classification Subcommittee | | 2011 | 650 |
| 15 | High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis | Nature Genetics | 2012 | 558 |
| 16 | Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services | British Journal of Surgery | 2020 | 554 |
| 17 | Adjunctive methotrexate for treatment of giant cell arteritis: An individual patient data meta‐analysis | Arthritis and Rheumatism | 2007 | 521 |
| 18 | Systematic review: the use of ultrasonography, computed tomography and magnetic resonance imaging for the diagnosis, assessment of activity and abdominal complications of Crohn’s disease | Alimentary Pharmacology and Therapeutics | 2011 | 513 |
| 19 | Tear Osmolarity in the Diagnosis and Management of Dry Eye Disease | American Journal of Ophthalmology | 2011 | 512 |
| 20 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 21 | Panniculitis. Part II. Mostly lobular panniculitis | Journal of the American Academy of Dermatology | 2001 | 481 |
| 22 | Predicting Nonmuscle Invasive Bladder Cancer Recurrence and Progression in Patients Treated With Bacillus Calmette-Guerin: The CUETO Scoring Model | Journal of Urology | 2009 | 480 |
| 23 | EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 473 |
| 24 | Joint international consensus statement for ending stigma of obesity | Nature Medicine | 2020 | 468 |
| 25 | Endoscopic management of Barrett’s esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement | Endoscopy | 2017 | 451 |
| 26 | Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children | PLoS Medicine | 2011 | 446 |
| 27 | Combined Treatment of Giant-Cell Arteritis with Methotrexate and Prednisone | Annals of Internal Medicine | 2001 | 439 |
| 28 | Non–heart-beating donation: Current state of the art | Transplantation Proceedings | 2004 | 433 |
| 29 | Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study | Blood | 2012 | 429 |
| 30 | Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial | European Heart Journal | 2015 | 406 |
| 31 | A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions | European Heart Journal | 2018 | 380 |
| 32 | EAACI Guidelines on allergen immunotherapy: IgE‐mediated food allergy | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 379 |
| 33 | Guía española de la enfermedad pulmonar obstructiva crónica (GesEPOC) 2017. Tratamiento farmacológico en fase estable | Archivos De Bronconeumologia | 2017 | 365 |
| 34 | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer | Nature Genetics | 2017 | 356 |
| 35 | The Universal Dynamics of Tumor Growth | Biophysical Journal | 2003 | 343 |
| 36 | Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013 | Annals of Oncology | 2015 | 327 |
| 37 | Systematic review of laparoscopic versus open surgery for colorectal cancer | British Journal of Surgery | 2006 | 322 |
| 38 | Cardiac manifestations of Anderson-Fabry disease: results from the international Fabry outcome survey | European Heart Journal | 2007 | 320 |
| 39 | Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial | Lancet, The | 2021 | 316 |
| 40 | Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis | European Journal of Internal Medicine | 2021 | 313 |
| 41 | A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population | Nature Genetics | 2010 | 309 |
| 42 | Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin | Blood | 2008 | 303 |
| 43 | Multicenter Core Laboratory Comparison of the Instantaneous Wave-Free Ratio and Resting P /P With Fractional Flow Reserve | Journal of the American College of Cardiology | 2014 | 301 |
| 44 | A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer | Annals of Oncology | 2014 | 297 |
| 45 | Drug-Eluting Stent Thrombosis | Journal of the American College of Cardiology | 2008 | 293 |
| 46 | Classification of HHV-6A and HHV-6B as distinct viruses | Archives of Virology | 2014 | 292 |
| 47 | Relation between Corneal Innervation with Confocal Microscopy and Corneal Sensitivity with Noncontact Esthesiometry in Patients with Dry Eye | | 2007 | 291 |
| 48 | Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus | Clinical Infectious Diseases | 2010 | 284 |
| 49 | Safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de-novo coronary artery lesions (BIOSOLVE-II): 6 month results of a prospective, multicentre, non-randomised, first-in-man trial | Lancet, The | 2016 | 284 |
| 50 | An In Vivo Confocal Masked Study on Corneal Epithelium and Subbasal Nerves in Patients with Dry Eye | | 2004 | 281 |
