| # | Title | Journal | Year | Citations |
|---|
| 1 | Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing | New England Journal of Medicine | 2012 | 6,769 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA | Science | 2004 | 3,050 |
| 4 | N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO | Nature Chemical Biology | 2011 | 2,936 |
| 5 | Targeting RAS signalling pathways in cancer therapy | Nature Reviews Cancer | 2003 | 2,800 |
| 6 | RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates | Science | 2006 | 1,965 |
| 7 | Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis | Nature | 2007 | 1,515 |
| 8 | Playing the End Game: DNA Double-Strand Break Repair Pathway Choice | Molecular Cell | 2012 | 1,349 |
| 9 | Role of PFKFB3-Driven Glycolysis in Vessel Sprouting | Cell | 2013 | 1,117 |
| 10 | The autophagosome: origins unknown, biogenesis complex | Nature Reviews Molecular Cell Biology | 2013 | 1,105 |
| 11 | Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 | Nature Immunology | 2007 | 1,070 |
| 12 | Six-of-the-best: unique contributions of γδ T cells to immunology | Nature Reviews Immunology | 2013 | 1,052 |
| 13 | Dendritic cells in a mature age | Nature Reviews Immunology | 2006 | 1,007 |
| 14 | Double-strand break repair: 53BP1 comes into focus | Nature Reviews Molecular Cell Biology | 2014 | 893 |
| 15 | Molecular views of recombination proteins and their control | Nature Reviews Molecular Cell Biology | 2003 | 860 |
| 16 | DNA interstrand crosslink repair and cancer | Nature Reviews Cancer | 2011 | 847 |
| 17 | Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations inMYH | New England Journal of Medicine | 2003 | 822 |
| 18 | Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting | Nature Cell Biology | 2010 | 820 |
| 19 | Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins | Immunity | 2005 | 815 |
| 20 | Toll-like receptor 3 promotes cross-priming to virus-infected cells | Nature | 2005 | 801 |
| 21 | How cancer metabolism is tuned for proliferation and vulnerable to disruption | Nature | 2012 | 800 |
| 22 | Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus | Nature Genetics | 2006 | 752 |
| 23 | Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all | Nature Reviews Molecular Cell Biology | 2006 | 744 |
| 24 | PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 | Open Biology | 2012 | 725 |
| 25 | Angiogenesis: A Team Effort Coordinated by Notch | Developmental Cell | 2009 | 707 |
| 26 | Replication stress links structural and numerical cancer chromosomal instability | Nature | 2013 | 694 |
| 27 | Wnt/β-catenin signaling controls development of the blood–brain barrier | Journal of Cell Biology | 2008 | 680 |
| 28 | Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair | Nature | 2015 | 671 |
| 29 | Identification of a candidate therapeutic autophagy-inducing peptide | Nature | 2013 | 669 |
| 30 | c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration | Neuron | 2012 | 661 |
| 31 | Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells | Annual Review of Genetics | 2004 | 658 |
| 32 | WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1 | Molecular Cell | 2014 | 650 |
| 33 | Identification of a dendritic cell receptor that couples sensing of necrosis to immunity | Nature | 2009 | 634 |
| 34 | Innate Recognition of Viruses | Immunity | 2007 | 614 |
| 35 | Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells | Journal of Experimental Medicine | 2010 | 613 |
| 36 | Cancer stem cell definitions and terminology: the devil is in the details | Nature Reviews Cancer | 2012 | 599 |
| 37 | The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network | Nature Reviews Cancer | 2007 | 576 |
| 38 | Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL | Science | 2007 | 569 |
| 39 | Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation | Autophagy | 2010 | 566 |
| 40 | Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function | Nature Immunology | 2005 | 564 |
| 41 | Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing | Cell | 2009 | 560 |
| 42 | Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility | Nature Cell Biology | 2009 | 554 |
| 43 | A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response | Nature | 2005 | 552 |
| 44 | Viral infection switches non-plasmacytoid dendritic cells into high interferon producers | Nature | 2003 | 544 |
| 45 | Cohesin relocation from sites of chromosomal loading to places of convergent transcription | Nature | 2004 | 544 |
| 46 | RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection | Molecular Cell | 2013 | 543 |
| 47 | Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice | Cell | 2007 | 524 |
| 48 | Glycolytic Enzymes Can Modulate Cellular Life Span | Cancer Research | 2005 | 523 |
| 49 | Colorectal cancer and genetic alterations in the Wnt pathway | Oncogene | 2006 | 522 |
| 50 | Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines | European Journal of Immunology | 2003 | 517 |
