| # | Title | Journal | Year | Citations |
|---|
| 1 | Virtual in Vivo Interactive Dissection of White Matter Fasciculi in the Human Brain | NeuroImage | 2002 | 1,515 |
| 2 | Curcumin: The story so far | European Journal of Cancer | 2005 | 1,420 |
| 3 | Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging | Magnetic Resonance in Medicine | 1999 | 1,303 |
| 4 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial | Lancet, The | 2009 | 1,292 |
| 5 | Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia | Nature Genetics | 1999 | 1,036 |
| 6 | Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis | Lancet, The | 2001 | 998 |
| 7 | The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis.. | British Journal of Dermatology | 1994 | 990 |
| 8 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial | Lancet, The | 2009 | 906 |
| 9 | Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis | Acta Psychiatrica Scandinavica | 2014 | 750 |
| 10 | Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial | Lancet, The | 2000 | 749 |
| 11 | CONTROLLED TRIAL OF URGENT ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY AND ENDOSCOPIC SPHINCTEROTOMY VERSUS CONSERVATIVE TREATMENT FOR ACUTE PANCREATITIS DUE TO GALLSTONES | Lancet, The | 1988 | 740 |
| 12 | Influenza | Lancet, The | 2003 | 724 |
| 13 | British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary | BMJ: British Medical Journal | 2004 | 713 |
| 14 | Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial | Lancet, The | 2007 | 660 |
| 15 | Haemophilias A and B | Lancet, The | 2003 | 650 |
| 16 | Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study | Lancet Oncology, The | 2011 | 612 |
| 17 | Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial | Lancet, The | 2001 | 609 |
| 18 | Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging | Magnetic Resonance in Medicine | 1999 | 607 |
| 19 | A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin-Naïve People With Type 2 Diabetes | Diabetes Care | 2006 | 605 |
| 20 | Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis | BMJ: British Medical Journal | 2010 | 584 |
| 21 | Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI | Magnetic Resonance in Medicine | 1999 | 544 |
| 22 | Urgency of caesarean section: A new classification | Journal of the Royal Society of Medicine | 2000 | 540 |
| 23 | Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2) | Lancet, The | 1992 | 536 |
| 24 | ESVS Guidelines. Invasive Treatment for Carotid Stenosis: Indications, Techniques | European Journal of Vascular and Endovascular Surgery | 2009 | 532 |
| 25 | In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias | Journal of Clinical Epidemiology | 2014 | 514 |
| 26 | European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia | European Respiratory Journal | 2017 | 465 |
| 27 | Obstetric Anaesthetists' Association and Difficult Airway Society guidelines for the management of difficult and failed tracheal intubation in obstetrics | Anaesthesia | 2015 | 458 |
| 28 | Assessment of cerebral pressure autoregulation in humans - a review of measurement methods | Physiological Measurement | 1998 | 455 |
| 29 | Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza | Lancet, The | 2001 | 439 |
| 30 | Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases - a review | NMR in Biomedicine | 2002 | 435 |
| 31 | Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2015 | 433 |
| 32 | Pooled Results From 38 Analyses of the Accuracy of Distress Thermometer and Other Ultra-Short Methods of Detecting Cancer-Related Mood Disorders | Journal of Clinical Oncology | 2007 | 411 |
| 33 | Severe persistent visual field constriction associated with vigabatrin | BMJ: British Medical Journal | 1997 | 407 |
| 34 | Electronic fetal heart rate monitoring: retrospective reflections on a twentieth-century technology | Journal of the Royal Society of Medicine | 1998 | 398 |
| 35 | Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis | Lancet, The | 1991 | 394 |
| 36 | Increased Matrix Metalloproteinase-9 Activity in Unstable Carotid Plaques | Stroke | 2000 | 385 |
| 37 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study | Lancet Oncology, The | 2014 | 384 |
| 38 | Broad-spectrum antibiotics for spontaneous preterm labour: the ORACLE II randomised trial | Lancet, The | 2001 | 375 |
| 39 | Circumferential mucosectomy (stapled haemorrhoidectomy) versus conventional haemorrhoidectomy: randomised controlled trial | Lancet, The | 2000 | 374 |
| 40 | Mutations in the Pericentrin ( PCNT ) Gene Cause Primordial Dwarfism | Science | 2008 | 370 |
| 41 | Dietary polyphenolic phytochemicals—promising cancer chemopreventive agents in humans? A review of their clinical properties | International Journal of Cancer | 2007 | 369 |
| 42 | Carotid Artery Disease and Stroke During Coronary Artery Bypass:a Critical Review of the Literature | European Journal of Vascular and Endovascular Surgery | 2002 | 368 |
| 43 | Recommendations for the use of botulinum toxin type A in the management of cerebral palsy | Gait and Posture | 2000 | 356 |
| 44 | Management of bleeding following major trauma: a European guideline | Critical Care | 2007 | 352 |
| 45 | Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study | The Lancet Child and Adolescent Health | 2020 | 352 |
| 46 | Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) Study | American Journal of Respiratory and Critical Care Medicine | 2005 | 345 |
| 47 | C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction | Circulation | 2007 | 333 |
| 48 | Optimization of Chemotherapy for Younger Patients With Acute Myeloid Leukemia: Results of the Medical Research Council AML15 Trial | Journal of Clinical Oncology | 2013 | 333 |
| 49 | Determining and visualizing uncertainty in estimates of fiber orientation from diffusion tensor MRI | Magnetic Resonance in Medicine | 2003 | 332 |
| 50 | Asymptomatic internal carotid artery stenosis and cerebrovascular risk stratification | Journal of Vascular Surgery | 2010 | 325 |
