| # | Title | Journal | Year | Citations |
|---|
| 1 | Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies | Lancet Neurology, The | 2008 | 2,696 |
| 2 | Capturing and profiling adult hair follicle stem cells | Nature Biotechnology | 2004 | 1,198 |
| 3 | Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy | Nature Medicine | 2005 | 998 |
| 4 | Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial | Lancet, The | 2010 | 913 |
| 5 | Aryl hydrocarbon receptor control of a disease tolerance defence pathway | Nature | 2014 | 574 |
| 6 | Novel Tryptophan Catabolic Enzyme IDO2 Is the Preferred Biochemical Target of the Antitumor Indoleamine 2,3-Dioxygenase Inhibitory Compound d-1-Methyl-Tryptophan | Cancer Research | 2007 | 453 |
| 7 | DNA repair mediated by endonuclease-independent LINE-1 retrotransposition | Nature Genetics | 2002 | 440 |
| 8 | Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes | Journal of the American College of Cardiology | 2016 | 401 |
| 9 | Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial | Lancet Neurology, The | 2010 | 399 |
| 10 | Dabigatran With or Without Concomitant Aspirin Compared With Warfarin Alone in Patients With Nonvalvular Atrial Fibrillation (PETRO Study) | American Journal of Cardiology | 2007 | 389 |
| 11 | Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models | Cell Death and Disease | 2012 | 379 |
| 12 | Occludin: Structure, function and regulation | Advanced Drug Delivery Reviews | 2005 | 378 |
| 13 | Indoleamine 2,3‐dioxygenase in T‐cell tolerance and tumoral immune escape | Immunological Reviews | 2008 | 368 |
| 14 | Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes | Blood | 2009 | 366 |
| 15 | IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan | OncoImmunology | 2012 | 338 |
| 16 | J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge | Heart Rhythm | 2016 | 322 |
| 17 | Immune escape as a fundamental trait of cancer: focus on IDO | Oncogene | 2008 | 313 |
| 18 | The Early Repolarization Pattern | Journal of the American College of Cardiology | 2015 | 306 |
| 19 | Rationale and design of RE-LY: Randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran | American Heart Journal | 2009 | 298 |
| 20 | Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: A subgroup analysis of TRENDS | Heart Rhythm | 2011 | 296 |
| 21 | IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development | Cancer Discovery | 2012 | 280 |
| 22 | Effect of Xuezhikang, an Extract From Red Yeast Chinese Rice, on Coronary Events in a Chinese Population With Previous Myocardial Infarction | American Journal of Cardiology | 2008 | 276 |
| 23 | Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non‐valvular atrial fibrillation from the RE‐LY trial | Journal of Thrombosis and Haemostasis | 2011 | 271 |
| 24 | The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists | Cancer Research | 2017 | 270 |
| 25 | Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease | Diabetes | 2001 | 251 |
| 26 | Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors | Nature Reviews Cancer | 2006 | 239 |
| 27 | RhoB and Actin Polymerization Coordinate Src Activation with Endosome-Mediated Delivery to the Membrane | Developmental Cell | 2004 | 235 |
| 28 | The Primary and Secondary Prevention of Coronary Artery Disease | Chest | 2008 | 234 |
| 29 | Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation | Journal of the American College of Cardiology | 2006 | 218 |
| 30 | Occurrence of death and stroke in patients in 47 countries 1 year after presenting with atrial fibrillation: a cohort study | Lancet, The | 2016 | 216 |
| 31 | Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 214 |
| 32 | Patients’ time in therapeutic range on warfarin among US patients with atrial fibrillation: Results from ORBIT-AF registry | American Heart Journal | 2015 | 211 |
| 33 | Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk | Journal of the American College of Cardiology | 2021 | 204 |
| 34 | Incidence of Previously Undiagnosed Atrial Fibrillation Using Insertable Cardiac Monitors in a High-Risk Population | JAMA Cardiology | 2017 | 200 |
| 35 | The Alpha-defensin Test for Periprosthetic Joint Infection Outperforms the Leukocyte Esterase Test Strip | Clinical Orthopaedics and Related Research | 2015 | 195 |
| 36 | Efficacy and Safety of Prescription Omega-3 Fatty Acids for the Prevention of Recurrent Symptomatic Atrial Fibrillation | JAMA - Journal of the American Medical Association | 2010 | 183 |
| 37 | Differences in Clinical and Functional Outcomes of Atrial Fibrillation in Women and Men | JAMA Cardiology | 2016 | 182 |
| 38 | J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge | Europace | 2017 | 172 |
| 39 | Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence | Molecular and Cellular Biology | 2001 | 170 |
| 40 | Immune control by amino acid catabolism during tumorigenesis and therapy | Nature Reviews Cancer | 2019 | 170 |
| 41 | Percutaneous Tricuspid Valve Replacement in Congenital and Acquired Heart Disease | Journal of the American College of Cardiology | 2011 | 169 |
| 42 | IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation | International Immunology | 2014 | 168 |
| 43 | International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries | American Heart Journal | 2017 | 161 |
| 44 | Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres | Nature | 2007 | 160 |
| 45 | Dabigatran and Warfarin in Vitamin K Antagonist–Naive and –Experienced Cohorts With Atrial Fibrillation | Circulation | 2010 | 158 |
| 46 | A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase | Oncogene | 2008 | 154 |
| 47 | Combinatorial Modification of Degradable Polymers Enables Transfection of Human Cells Comparable to Adenovirus | Advanced Materials | 2007 | 151 |
| 48 | Phase 2 Reentry as a Trigger to Initiate Ventricular Fibrillation During Early Acute Myocardial Ischemia | Circulation | 2004 | 146 |
| 49 | Frequency and Outcomes of Reduced Dose Non–Vitamin K Antagonist Anticoagulants: Results From ORBIT‐AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II) | Journal of the American Heart Association | 2018 | 143 |
| 50 | Detection of Previously Undiagnosed Atrial Fibrillation in Patients With Stroke Risk Factors and Usefulness of Continuous Monitoring in Primary Stroke Prevention | American Journal of Cardiology | 2012 | 140 |
