Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth | Nature | 2012 | 873 |
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients | Journal of Experimental Medicine | 2012 | 448 |
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice | Gastroenterology | 2012 | 400 |
STAT5 is a potent negative regulator of TFH cell differentiation | Journal of Experimental Medicine | 2012 | 360 |
Immune epitope database analysis resource | Nucleic Acids Research | 2012 | 322 |
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 290 |
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis | Circulation Research | 2012 | 287 |
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome | Nature Chemical Biology | 2012 | 267 |
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation | Journal of Immunology | 2012 | 255 |
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function | Genes and Development | 2012 | 218 |
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation | Blood | 2012 | 172 |
Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis | Journal of Clinical Investigation | 2012 | 167 |
Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice | Gastroenterology | 2012 | 153 |
TNF superfamily in inflammatory disease: translating basic insights | Trends in Immunology | 2012 | 148 |
Adenosine A2B receptor blockade slows growth of bladder and breast tumors | Journal of Immunology | 2012 | 147 |
Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 147 |
'Slings' enable neutrophil rolling at high shear | Nature | 2012 | 130 |
STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2012 | 115 |
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria | Nature | 2012 | 94 |
Neutrophil arrest by LFA-1 activation | Frontiers in Immunology | 2012 | 91 |
Mitochondrial pathway of apoptosis is ancestral in metazoans | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 88 |
Gamma interferon (IFN-γ) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-α/β receptor-deficient mice | Journal of Virology | 2012 | 81 |
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions | Nature Communications | 2012 | 76 |
Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes | PLoS Biology | 2012 | 76 |
Structural consensus among antibodies defines the antigen binding site | PLoS Computational Biology | 2012 | 73 |