| # | Title | Journal | Year | Citations |
|---|
| 1 | Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2000 | 14,454 |
| 2 | Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults | Clinical Infectious Diseases | 2007 | 5,203 |
| 3 | Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2004 | 2,302 |
| 4 | The Timing of Prophylactic Administration of Antibiotics and the Risk of Surgical-Wound Infection | New England Journal of Medicine | 1992 | 1,672 |
| 5 | Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias | Nature Genetics | 1996 | 1,663 |
| 6 | Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide | New England Journal of Medicine | 1999 | 1,376 |
| 7 | A Computer-Assisted Management Program for Antibiotics and Other Antiinfective Agents | New England Journal of Medicine | 1998 | 1,035 |
| 8 | Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. | American Journal of Respiratory and Critical Care Medicine | 1994 | 954 |
| 9 | Infection Control — A Problem for Patient Safety | New England Journal of Medicine | 2003 | 942 |
| 10 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial | Lancet Oncology, The | 2007 | 915 |
| 11 | Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease | Annals of Internal Medicine | 2000 | 905 |
| 12 | Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning | New England Journal of Medicine | 2002 | 812 |
| 13 | Which White Blood Cell Subtypes Predict Increased Cardiovascular Risk? | Journal of the American College of Cardiology | 2005 | 785 |
| 14 | Long-Term, Low-Intensity Warfarin Therapy for the Prevention of Recurrent Venous Thromboembolism | New England Journal of Medicine | 2003 | 771 |
| 15 | Early activity is feasible and safe in respiratory failure patients* | Critical Care Medicine | 2007 | 771 |
| 16 | Outcomes of Left Ventricular Assist Device Implantation as Destination Therapy in the Post-REMATCH Era | Circulation | 2007 | 733 |
| 17 | Influence of the Genotype on the Clinical Course of the Long-QT Syndrome | New England Journal of Medicine | 1998 | 728 |
| 18 | Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: Preliminary Results of a Phase III Trial in Regionally Advanced, Unresectable Non-Small-Cell Lung Cancer | Journal of the National Cancer Institute | 1995 | 693 |
| 19 | Two-Year Cognitive, Emotional, and Quality-of-Life Outcomes in Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | 2005 | 693 |
| 20 | Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation | Circulation | 2007 | 660 |
| 21 | The Spectrum of Symptoms and QT Intervals in Carriers of the Gene for the Long-QT Syndrome | New England Journal of Medicine | 1992 | 626 |
| 22 | Neuropsychological Sequelae and Impaired Health Status in Survivors of Severe Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | 1999 | 611 |
| 23 | Carbon Monoxide Poisoning | New England Journal of Medicine | 2009 | 599 |
| 24 | Final Results of Phase III Trial in Regionally Advanced Unresectable Non-Small Cell Lung Cancer | Chest | 2000 | 594 |
| 25 | Non-Hodgkin's lymphoma of the brain: Can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation therapy Oncology Group (RTOG): RTOG 8315 | International Journal of Radiation Oncology Biology Physics | 1992 | 584 |
| 26 | Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: Report of Radiation Therapy Oncology Group 93-05 protocol | International Journal of Radiation Oncology Biology Physics | 2004 | 527 |
| 27 | Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality | JAMA - Journal of the American Medical Association | 1997 | 524 |
| 28 | Implementing Antibiotic Practice Guidelines through Computer-Assisted Decision Support: Clinical and Financial Outcomes | Annals of Internal Medicine | 1996 | 514 |
| 29 | Infection With Chlamydia pneumoniae Accelerates the Development of Atherosclerosis and Treatment With Azithromycin Prevents It in a Rabbit Model | Circulation | 1998 | 488 |
| 30 | Direct Blood Pressure Measurement —Dynamic Response Requirements | Anesthesiology | 1981 | 480 |
| 31 | Spectrum of ST-T–Wave Patterns and Repolarization Parameters in Congenital Long-QT Syndrome | Circulation | 2000 | 409 |
| 32 | Pseudopalisades in Glioblastoma Are Hypoxic, Express Extracellular Matrix Proteases, and Are Formed by an Actively Migrating Cell Population | Cancer Research | 2004 | 401 |
| 33 | Long-term treatment sequelae following external beam irradiation for adenocarcinoma of the prostate: analysis of RTOG studies 7506 and 7706 | International Journal of Radiation Oncology Biology Physics | 1991 | 399 |
| 34 | Increased incidence of Chlamydiaspecies within the coronary arteries of patients with symptomatic atherosclerotic versus other forms of cardiovascular disease | Journal of the American College of Cardiology | 1996 | 382 |
| 35 | Mutations of the TGF-β type II receptorBMPR2 in pulmonary arterial hypertension | Human Mutation | 2006 | 368 |
| 36 | Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation | Bone Marrow Transplantation | 2016 | 364 |
| 37 | Electronic Health Records: Then, Now, and in the Future | Yearbook of Medical Informatics | 2016 | 354 |
| 38 | Chronic Opioid Use is a Risk Factor for the Development of Central Sleep Apnea and Ataxic Breathing | Journal of Clinical Sleep Medicine | 2007 | 351 |
| 39 | Azithromycin for the Secondary Prevention of Coronary Events | New England Journal of Medicine | 2005 | 348 |
| 40 | Inaccurate electrocardiographic interpretation of long QT: The majority of physicians cannot recognize a long QT when they see one | Heart Rhythm | 2005 | 345 |
| 41 | Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation | Lancet, The | 1998 | 340 |
| 42 | Long-term Neurocognitive Function After Critical Illness | Chest | 2006 | 337 |
| 43 | An emergency department-based protocol for rapidly ruling out myocardial ischemia reduces hospital time and expense: Results of a randomized study (ROMIO) | Journal of the American College of Cardiology | 1996 | 333 |
| 44 | Randomized Secondary Prevention Trial of Azithromycin in Patients With Coronary Artery Disease and Serological Evidence forChlamydia pneumoniaeInfection | Circulation | 1999 | 332 |
| 45 | Validation and Predictive Power of Radiation Therapy Oncology Group (RTOG) Recursive Partitioning Analysis Classes for Malignant Glioma Patients: A Report Using RTOG 90-06☆ | International Journal of Radiation Oncology Biology Physics | 1998 | 309 |
| 46 | Higher Serum Bilirubin Is Associated With Decreased Risk for Early Familial Coronary Artery Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 1996 | 304 |
| 47 | Timing of Antimicrobial Prophylaxis and the Risk of Surgical Site Infections | Annals of Surgery | 2009 | 303 |
| 48 | Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life | American Journal of Neuroradiology | 1995 | 301 |
| 49 | Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT) | Bone Marrow Transplantation | 2015 | 294 |
| 50 | Opioid-Related Adverse Drug Events in Surgical Hospitalizations: Impact on Costs and Length of Stay | Annals of Pharmacotherapy | 2007 | 291 |
