| # | Title | Journal | Year | Citations |
|---|
| 1 | Complete sequencing and characterization of 21,243 full-length human cDNAs | Nature Genetics | 2004 | 796 |
| 2 | The Corynebacterium glutamicum genome: features and impacts on biotechnological processes | Applied Microbiology and Biotechnology | 2003 | 493 |
| 3 | Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease | Kidney International | 2010 | 279 |
| 4 | Therapeutic Effects of Anti-FGF23 Antibodies in Hypophosphatemic Rickets/Osteomalacia | Journal of Bone and Mineral Research | 2009 | 224 |
| 5 | A Novel Human CC Chemokine, Eotaxin-3, Which Is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils | Journal of Immunology | 1999 | 217 |
| 6 | Enhancement of disease resistance of kuruma shrimp, Penaeus japonicus, after oral administration of peptidoglycan derived from Bifidobacterium thermophilum | Aquaculture | 1998 | 209 |
| 7 | A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils | Journal of Immunology | 1999 | 184 |
| 8 | Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density | Clinical Cancer Research | 2005 | 176 |
| 9 | The duality of teleost gonadotropins | Fish Physiology and Biochemistry | 1989 | 170 |
| 10 | Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease | Trends in Pharmacological Sciences | 1997 | 159 |
| 11 | A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response | Blood | 2009 | 159 |
| 12 | Extensive Genomic Diversity in Pathogenic Escherichia coli and Shigella Strains Revealed by Comparative Genomic Hybridization Microarray | Journal of Bacteriology | 2004 | 156 |
| 13 | Stimulation of RNA Polymerase II Elongation by Hepatitis Delta Antigen | Science | 2001 | 149 |
| 14 | Tudor domain containing 7 ( Tdrd7 ) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 126 |
| 15 | The structures of the novel protein kinase C inhibitors K-252a, b, c and d. | Journal of Antibiotics | 1986 | 125 |
| 16 | Systemic administration of adenosine A2A receptor antagonist reverses increased GABA release in the globus pallidus of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study | Neuroscience | 2000 | 123 |
| 17 | Concerted expression of eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells | Cellular Immunology | 2003 | 121 |
| 18 | A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced FcγRIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques | Journal of Virology | 2012 | 110 |
| 19 | Cellular Localization and Expression of Template-Activating Factor I in Different Cell Types | Experimental Cell Research | 1998 | 109 |
| 20 | KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation | Blood | 2009 | 108 |
| 21 | Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro | Molecular and Cellular Biology | 2004 | 106 |
| 22 | Potent and preferential inhibition of Ca2+ / calmodulin-dependent protein kinase II by K252a and its derivative, KT5926 | Biochemical and Biophysical Research Communications | 1991 | 85 |
| 23 | Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells | Blood | 2009 | 85 |
| 24 | PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2 | Nature Medicine | 2010 | 85 |
| 25 | Efficient 40�C fermentation of l-lysine by a new Corynebacterium glutamicum mutant developed by genome breeding | Applied Microbiology and Biotechnology | 2003 | 76 |
| 26 | Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo11The authors disclosed conflict of interest. | Journal of Investigative Dermatology | 1999 | 75 |
| 27 | Isolation of two forms of growth hormone secreted from eel pituitaries in vitro | General and Comparative Endocrinology | 1987 | 73 |
| 28 | Identification of genes involved in epithelial-mesenchymal transition and tumor progression | Oncogene | 2001 | 72 |
| 29 | A Phase 2a Study of Benralizumab for Patients with Eosinophilic Asthma in South Korea and Japan | International Archives of Allergy and Immunology | 2016 | 70 |
| 30 | Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ | Kidney International | 2015 | 64 |
| 31 | Unique binding pocket for KW-4679 in the histamine H1 receptor | European Journal of Pharmacology | 1998 | 61 |
| 32 | Effect of oral glutathione on hepatic glutathione levels in rats and mice | British Journal of Nutrition | 1989 | 57 |
| 33 | Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-II via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix | Cancer Science | 2007 | 55 |
| 34 | Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients | Journal of Steroid Biochemistry and Molecular Biology | 2003 | 54 |
| 35 | Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats | American Journal of Physiology - Renal Physiology | 1999 | 53 |
| 36 | Enhancement of resistance against Enterococcus seriolicida infection in yellowtail, Seriola quinqueradiata (Temminck & Schlegel), by oral administration of peptidoglycan derived from Bifidobacterium thermophilum | Journal of Fish Diseases | 1996 | 43 |
| 37 | Mogamulizumab versus investigator’s choice of chemotherapy regimen in relapsed/refractory adult T-cell leukemia/lymphoma | Haematologica | 2019 | 43 |
| 38 | Carbon-11-labeled KF21213: a highly selective ligand for mapping CNS adenosine A2A receptors with positron emission tomography | Nuclear Medicine and Biology | 2000 | 41 |
| 39 | Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model | Journal of Infectious Diseases | 2011 | 38 |
| 40 | An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study | Lancet, The | 2023 | 38 |
| 41 | Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization | Journal of Cell Science | 2012 | 36 |
| 42 | Genetically engineered humanized anti‐ganglioside GM2 antibody against multiple organ metastasis produced by GM2‐expressing small‐cell lung cancer cells | Cancer Science | 2011 | 31 |
| 43 | An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy | Laboratory Investigation | 2012 | 31 |
| 44 | Reactivation of hepatitis B virus in a patient with adult T‐cell leukemia–lymphoma receiving the anti‐CC chemokine receptor 4 antibody mogamulizumab | Hepatology Research | 2014 | 30 |
| 45 | Renal role of the endogenous natriuretic peptide system in acute congestive heart failure | Journal of Cardiac Failure | 1996 | 29 |
| 46 | Age and anemia management: relationship of hemoglobin levels with mortality might differ between elderly and nonelderly hemodialysis patients | Nephrology Dialysis Transplantation | 2014 | 29 |
| 47 | Immunochemical characterisation and epitope mapping of a novel fimbrial protein (Pg-II fimbria) ofPorphyromonas gingivalis | FEMS Immunology and Medical Microbiology | 1995 | 27 |
| 48 | Localization of estrone sulfatase in human breast carcinomas | Breast Cancer | 1999 | 27 |
| 49 | A synthetic peptide deduced from the sequence in the cross-region of laminin A chain mediates neurite outgrowth, cell attachment and heparin binding | Biochemical Journal | 1994 | 25 |
| 50 | Hair follicle elongation in organ culture of skin from newborn and adult mice | Journal of Dermatological Science | 1998 | 25 |
