| # | Title | Journal | Year | Citations |
|---|
| 1 | The complete genome sequence of the Gram-positive bacterium Bacillus subtilis | Nature | 1997 | 3,519 |
| 2 | Thioredoxin-interacting protein links oxidative stress to inflammasome activation | Nature Immunology | 2010 | 2,163 |
| 3 | Genome evolution and adaptation in a long-term experiment with Escherichia coli | Nature | 2009 | 1,038 |
| 4 | Comparison of several methods for effective lipid extraction from microalgae | Bioresource Technology | 2010 | 1,013 |
| 5 | Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer | Cell | 2002 | 957 |
| 6 | Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States | Diabetes | 2006 | 932 |
| 7 | Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum species | Nature Genetics | 2014 | 867 |
| 8 | CHO cells in biotechnology for production of recombinant proteins: current state and further potential | Applied Microbiology and Biotechnology | 2012 | 599 |
| 9 | Selection of microalgae for lipid production under high levels carbon dioxide | Bioresource Technology | 2010 | 569 |
| 10 | Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling | Cell | 2010 | 542 |
| 11 | Gram‐positive bacteria produce membrane vesicles: Proteomics‐based characterization of Staphylococcus aureus‐derived membrane vesicles | Proteomics | 2009 | 532 |
| 12 | Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines | Virus Genes | 2012 | 530 |
| 13 | Interleukin-32 | Immunity | 2005 | 520 |
| 14 | Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids | FEBS Letters | 2005 | 508 |
| 15 | Vitamin D3 Up-Regulated Protein 1 Mediates Oxidative Stress Via Suppressing the Thioredoxin Function | Journal of Immunology | 2000 | 439 |
| 16 | Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition | Bioorganic and Medicinal Chemistry | 2010 | 433 |
| 17 | Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death | Oncotarget | 2015 | 422 |
| 18 | Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism | FASEB Journal | 2004 | 407 |
| 19 | Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer | Nature Genetics | 2020 | 380 |
| 20 | Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy | ACS Nano | 2014 | 373 |
| 21 | Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP | Diabetes | 2008 | 368 |
| 22 | Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution | Nature Structural Biology | 1998 | 351 |
| 23 | Role of bacterial volatile compounds in bacterial biology | FEMS Microbiology Reviews | 2015 | 329 |
| 24 | Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis | Nature Cell Biology | 2016 | 329 |
| 25 | Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast | Science | 2008 | 328 |
| 26 | Excess of De Novo Deleterious Mutations in Genes Associated with Glutamatergic Systems in Nonsyndromic Intellectual Disability | American Journal of Human Genetics | 2011 | 310 |
| 27 | Chemical modification of siRNAs to improve serum stability without loss of efficacy | Biochemical and Biophysical Research Communications | 2006 | 300 |
| 28 | Gene-set approach for expression pattern analysis | Briefings in Bioinformatics | 2008 | 299 |
| 29 | Construction and Manipulation of a New Kaposi's Sarcoma-Associated Herpesvirus Bacterial Artificial Chromosome Clone | Journal of Virology | 2012 | 296 |
| 30 | Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones | PLoS Biology | 2004 | 290 |
| 31 | Aberrant Epigenetic Modifications in Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein | Gastroenterology | 2007 | 282 |
| 32 | Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage | Molecular and Cellular Biochemistry | 2003 | 274 |
| 33 | O-GlcNAc Regulates Pluripotency and Reprogramming by Directly Acting on Core Components of the Pluripotency Network | Cell Stem Cell | 2012 | 268 |
| 34 | Protein-Based Nanoparticles as Drug Delivery Systems | Pharmaceutics | 2020 | 268 |
| 35 | Highly Sensitive Biosensing Using Arrays of Plasmonic Au Nanodisks Realized by Nanoimprint Lithography | ACS Nano | 2011 | 265 |
| 36 | Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway | Cell | 2006 | 264 |
| 37 | Angiotensin I-converting enzyme inhibitory peptide from yellowfin sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats | Food Chemistry | 2006 | 261 |
| 38 | Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH | Analytical Biochemistry | 2000 | 259 |
| 39 | New reference genome sequences of hot pepper reveal the massive evolution of plant disease-resistance genes by retroduplication | Genome Biology | 2017 | 255 |
| 40 | Differences in Gastric Mucosal Microbiota Profiling in Patients with Chronic Gastritis, Intestinal Metaplasia, and Gastric Cancer Using Pyrosequencing Methods | Helicobacter | 2014 | 253 |
| 41 | Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in Cells | Science | 1999 | 249 |
| 42 | Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production | Blood | 2009 | 249 |
| 43 | Microcystin Production by Microcystis aeruginosa in a Phosphorus-Limited Chemostat | Applied and Environmental Microbiology | 2000 | 248 |
| 44 | VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression | Oncogene | 2003 | 248 |
| 45 | Dynamic Chemical Communication between Plants and Bacteria through Airborne Signals: Induced Resistance by Bacterial Volatiles | Journal of Chemical Ecology | 2013 | 248 |
| 46 | Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris | Biotechnology Letters | 2012 | 247 |
| 47 | Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome | American Journal of Physiology - Renal Physiology | 2011 | 246 |
| 48 | Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro | Cell Discovery | 2020 | 246 |
| 49 | Induced Resistance by a Long-Chain Bacterial Volatile: Elicitation of Plant Systemic Defense by a C13 Volatile Produced by Paenibacillus polymyxa | PLoS ONE | 2012 | 246 |
| 50 | Hepatitis B Virus X Protein Induces Hepatic Steatosis Via Transcriptional Activation of SREBP1 and PPARγ | Gastroenterology | 2007 | 245 |
